# American Institute of Mathematical Sciences

January  2012, 11(1): 229-241. doi: 10.3934/cpaa.2012.11.229

## Stability of nonconstant stationary solutions in a reaction-diffusion equation coupled to the system of ordinary differential equations

 1 Department of Mechanics and Mathematics, Franko Lviv National University, Lviv 79000, Ukraine 2 University of Heidelberg, Interdisciplinary Center for Scientific Computing (IWR), Institute of Applied Mathematics and BIOQUANT, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany 3 Department of Mathematics I, RWTH Aachen University, Wüllnerstr. 5b, 52056 Aachen, Germany

Received  March 2010 Revised  January 2011 Published  September 2011

In this paper we study pattern formation arising in a system of a single reaction-diffusion equation coupled with subsystem of ordinary differential equations, describing spatially-distributed growth of clonal populations of precancerous cells, whose proliferation is controlled by growth factors diffusing in the extracellular medium and binding to the cell surface. We extend the results on the existence of nonhomogenous stationary solutions obtained in [9] to a general Hill-type production function and full parameter set. Using spectral analysis and perturbation theory we derive conditions for the linearized stability of such spatial patterns.
Citation: Yuriy Golovaty, Anna Marciniak-Czochra, Mariya Ptashnyk. Stability of nonconstant stationary solutions in a reaction-diffusion equation coupled to the system of ordinary differential equations. Communications on Pure & Applied Analysis, 2012, 11 (1) : 229-241. doi: 10.3934/cpaa.2012.11.229
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