# American Institute of Mathematical Sciences

2006, 3(2): 313-324. doi: 10.3934/mbe.2006.3.313

## Modeling Cancer in HIV-1 Infected Individuals: Equilibria, Cycles and Chaotic Behavior

 1 Department of Mathematics, Shanghai University, 99 Shangda Road Shanghai 200444, P. R., China 2 Department of Mathematics and, Research Center of Applied Mathematics (CIRAM), University of Bologna, Via Saragozza 8, 40123 Bologna, Italy 3 Dipartimento di Matematica, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy

Received  September 2005 Revised  January 2006 Published  February 2006

For HIV-infected individuals, cancer remains a significant burden. Gaining insight into the epidemiology and mechanisms that underlie AIDS-related cancers can provide us with a better understanding of cancer immunity and viral oncogenesis. In this paper, an HIV-1 dynamical model incorporating the AIDS-related cancer cells was studied. The model consists of three components, cancer cells, healthy CD4+ T lymphocytes and infected CD4+ T lymphocytes, and can have six steady states. We discuss the existence, the stability properties and the biological meanings of these steady states, in particular for the positive one: cancer-HIV-healthy cells steady state. We find conditions for Hopf bifurcation of the positive steady state, leading to periodic solutions, sequences of period doubling bifurcations and appearance of chaos. Further, chaos and periodic behavior alternate. Our results are consistent with some clinical and experimental observations.
Citation: Jie Lou, Tommaso Ruggeri, Claudio Tebaldi. Modeling Cancer in HIV-1 Infected Individuals: Equilibria, Cycles and Chaotic Behavior. Mathematical Biosciences & Engineering, 2006, 3 (2) : 313-324. doi: 10.3934/mbe.2006.3.313
 [1] Hui Miao, Zhidong Teng, Chengjun Kang. Stability and Hopf bifurcation of an HIV infection model with saturation incidence and two delays. Discrete & Continuous Dynamical Systems - B, 2017, 22 (6) : 2365-2387. doi: 10.3934/dcdsb.2017121 [2] Jinhu Xu, Yicang Zhou. Bifurcation analysis of HIV-1 infection model with cell-to-cell transmission and immune response delay. Mathematical Biosciences & Engineering, 2016, 13 (2) : 343-367. doi: 10.3934/mbe.2015006 [3] Jinliang Wang, Lijuan Guan. Global stability for a HIV-1 infection model with cell-mediated immune response and intracellular delay. Discrete & Continuous Dynamical Systems - B, 2012, 17 (1) : 297-302. doi: 10.3934/dcdsb.2012.17.297 [4] Rachid Ouifki, Gareth Witten. A model of HIV-1 infection with HAART therapy and intracellular delays. Discrete & Continuous Dynamical Systems - B, 2007, 8 (1) : 229-240. doi: 10.3934/dcdsb.2007.8.229 [5] Gesham Magombedze, Winston Garira, Eddie Mwenje. Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: The role of fusion inhibitors in HAART. Mathematical Biosciences & Engineering, 2008, 5 (3) : 485-504. doi: 10.3934/mbe.2008.5.485 [6] Huiyan Zhu, Xingfu Zou. Dynamics of a HIV-1 Infection model with cell-mediated immune response and intracellular delay. Discrete & Continuous Dynamical Systems - B, 2009, 12 (2) : 511-524. doi: 10.3934/dcdsb.2009.12.511 [7] Shengqiang Liu, Lin Wang. Global stability of an HIV-1 model with distributed intracellular delays and a combination therapy. Mathematical Biosciences & Engineering, 2010, 7 (3) : 675-685. doi: 10.3934/mbe.2010.7.675 [8] Na Min, Mingxin Wang. Hopf bifurcation and steady-state bifurcation for a Leslie-Gower prey-predator model with strong Allee effect in prey. Discrete & Continuous Dynamical Systems - A, 2019, 39 (2) : 1071-1099. doi: 10.3934/dcds.2019045 [9] Kousuke Kuto. Stability and Hopf bifurcation of coexistence steady-states to an SKT model in spatially heterogeneous environment. Discrete & Continuous Dynamical Systems - A, 2009, 24 (2) : 489-509. doi: 10.3934/dcds.2009.24.489 [10] Bing Li, Yuming Chen, Xuejuan Lu, Shengqiang Liu. A delayed HIV-1 model with virus waning term. Mathematical Biosciences & Engineering, 2016, 13 (1) : 135-157. doi: 10.3934/mbe.2016.13.135 [11] Yun Tian, Yu Bai, Pei Yu. Impact of delay on HIV-1 dynamics of fighting a virus with another virus. Mathematical Biosciences & Engineering, 2014, 11 (5) : 1181-1198. doi: 10.3934/mbe.2014.11.1181 [12] Dmitriy Yu. Volkov. The Hopf -- Hopf bifurcation with 2:1 resonance: Periodic solutions and invariant tori. Conference Publications, 2015, 2015 (special) : 1098-1104. doi: 10.3934/proc.2015.1098 [13] Hossein Mohebbi, Azim Aminataei, Cameron J. Browne, Mohammad Reza Razvan. Hopf bifurcation of an age-structured virus infection model. Discrete & Continuous Dynamical Systems - B, 2018, 23 (2) : 861-885. doi: 10.3934/dcdsb.2018046 [14] Tinevimbo Shiri, Winston Garira, Senelani D. Musekwa. A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters. Mathematical Biosciences & Engineering, 2005, 2 (4) : 811-832. doi: 10.3934/mbe.2005.2.811 [15] Xia Wang, Shengqiang Liu, Libin Rong. Permanence and extinction of a non-autonomous HIV-1 model with time delays. Discrete & Continuous Dynamical Systems - B, 2014, 19 (6) : 1783-1800. doi: 10.3934/dcdsb.2014.19.1783 [16] Shixing Li, Dongming Yan. On the steady state bifurcation of the Cahn-Hilliard/Allen-Cahn system. Discrete & Continuous Dynamical Systems - B, 2019, 24 (7) : 3077-3088. doi: 10.3934/dcdsb.2018301 [17] Fabien Crauste. Global Asymptotic Stability and Hopf Bifurcation for a Blood Cell Production Model. Mathematical Biosciences & Engineering, 2006, 3 (2) : 325-346. doi: 10.3934/mbe.2006.3.325 [18] Yu Ji. Global stability of a multiple delayed viral infection model with general incidence rate and an application to HIV infection. Mathematical Biosciences & Engineering, 2015, 12 (3) : 525-536. doi: 10.3934/mbe.2015.12.525 [19] Yan'e Wang, Jianhua Wu. Stability of positive constant steady states and their bifurcation in a biological depletion model. Discrete & Continuous Dynamical Systems - B, 2011, 15 (3) : 849-865. doi: 10.3934/dcdsb.2011.15.849 [20] La-Su Mai, Kaijun Zhang. Asymptotic stability of steady state solutions for the relativistic Euler-Poisson equations. Discrete & Continuous Dynamical Systems - A, 2016, 36 (2) : 981-1004. doi: 10.3934/dcds.2016.36.981

2018 Impact Factor: 1.313