2010, 7(2): 277-300. doi: 10.3934/mbe.2010.7.277

A pressure model of immune response to mycobacterium tuberculosis infection in several space dimensions

1. 

Istituto per le Applicazioni del Calcolo “M. Picone”, CNR, c/o Dip. di Matematica, Università di Roma “Tor Vergata”, Via della Ricerca Scientifica, 1; I-00133 Roma, Italy, Italy

Received  January 2009 Revised  October 2009 Published  April 2010

Mycobacterium tuberculosis (Mtb) is a widely diffused infection. However, in general, the human immune system is able to contain it. In this work, we propose a mathematical model which describes the early immune response to the Mtb infection in the lungs, also including the possible evolution of the infection in the formation of a granuloma. The model is based on coupled reaction-diffusion-transport equations with chemotaxis, which take into account the interactions among bacteria, macrophages and chemoattractant. The novelty of this approach is in the modeling of the velocity field, proportional to the gradient of the pressure developed between the cells, which makes possible to deal with a full multidimensional description and efficient numerical simulations. We perform a linear stability analysis of the model and propose a robust implicit-explicit scheme to deal with long time simulations. Both in one and two-dimensions, we find that there are threshold values in the parameters space, between a contained infection and the uncontrolled bacteria growth, and the generation of granuloma-like patterns can be observed numerically.
Citation: Fabrizio Clarelli, Roberto Natalini. A pressure model of immune response to mycobacterium tuberculosis infection in several space dimensions. Mathematical Biosciences & Engineering, 2010, 7 (2) : 277-300. doi: 10.3934/mbe.2010.7.277
[1]

Xinfu Chen, King-Yeung Lam, Yuan Lou. Corrigendum: Dynamics of a reaction-diffusion-advection model for two competing species. Discrete & Continuous Dynamical Systems - A, 2014, 34 (11) : 4989-4995. doi: 10.3934/dcds.2014.34.4989

[2]

Xinfu Chen, King-Yeung Lam, Yuan Lou. Dynamics of a reaction-diffusion-advection model for two competing species. Discrete & Continuous Dynamical Systems - A, 2012, 32 (11) : 3841-3859. doi: 10.3934/dcds.2012.32.3841

[3]

Masaharu Taniguchi. Multi-dimensional traveling fronts in bistable reaction-diffusion equations. Discrete & Continuous Dynamical Systems - A, 2012, 32 (3) : 1011-1046. doi: 10.3934/dcds.2012.32.1011

[4]

Danhua Jiang, Zhi-Cheng Wang, Liang Zhang. A reaction-diffusion-advection SIS epidemic model in a spatially-temporally heterogeneous environment. Discrete & Continuous Dynamical Systems - B, 2018, 23 (10) : 4557-4578. doi: 10.3934/dcdsb.2018176

[5]

Chris Cosner. Reaction-diffusion-advection models for the effects and evolution of dispersal. Discrete & Continuous Dynamical Systems - A, 2014, 34 (5) : 1701-1745. doi: 10.3934/dcds.2014.34.1701

[6]

Pan Zheng. Global boundedness and decay for a multi-dimensional chemotaxis-haptotaxis system with nonlinear diffusion. Discrete & Continuous Dynamical Systems - B, 2016, 21 (6) : 2039-2056. doi: 10.3934/dcdsb.2016035

[7]

Abba B. Gumel, Baojun Song. Existence of multiple-stable equilibria for a multi-drug-resistant model of mycobacterium tuberculosis. Mathematical Biosciences & Engineering, 2008, 5 (3) : 437-455. doi: 10.3934/mbe.2008.5.437

[8]

Tong Li, Anthony Suen. Existence of intermediate weak solution to the equations of multi-dimensional chemotaxis systems. Discrete & Continuous Dynamical Systems - A, 2016, 36 (2) : 861-875. doi: 10.3934/dcds.2016.36.861

[9]

Mostafa Bendahmane, Kenneth H. Karlsen. Renormalized solutions of an anisotropic reaction-diffusion-advection system with $L^1$ data. Communications on Pure & Applied Analysis, 2006, 5 (4) : 733-762. doi: 10.3934/cpaa.2006.5.733

[10]

Anna Kostianko, Sergey Zelik. Inertial manifolds for 1D reaction-diffusion-advection systems. Part Ⅰ: Dirichlet and Neumann boundary conditions. Communications on Pure & Applied Analysis, 2017, 16 (6) : 2357-2376. doi: 10.3934/cpaa.2017116

[11]

Anna Kostianko, Sergey Zelik. Inertial manifolds for 1D reaction-diffusion-advection systems. Part Ⅱ: periodic boundary conditions. Communications on Pure & Applied Analysis, 2018, 17 (1) : 285-317. doi: 10.3934/cpaa.2018017

[12]

Linfeng Mei, Xiaoyan Zhang. On a nonlocal reaction-diffusion-advection system modeling phytoplankton growth with light and nutrients. Discrete & Continuous Dynamical Systems - B, 2012, 17 (1) : 221-243. doi: 10.3934/dcdsb.2012.17.221

[13]

Bo Duan, Zhengce Zhang. A two-species weak competition system of reaction-diffusion-advection with double free boundaries. Discrete & Continuous Dynamical Systems - B, 2019, 24 (2) : 801-829. doi: 10.3934/dcdsb.2018208

[14]

Eduardo Ibargüen-Mondragón, Lourdes Esteva, Edith Mariela Burbano-Rosero. Mathematical model for the growth of Mycobacterium tuberculosis in the granuloma. Mathematical Biosciences & Engineering, 2018, 15 (2) : 407-428. doi: 10.3934/mbe.2018018

[15]

Hiroshi Takahashi, Yozo Tamura. Recurrence of multi-dimensional diffusion processes in Brownian environments. Conference Publications, 2015, 2015 (special) : 1034-1040. doi: 10.3934/proc.2015.1034

[16]

Suman Ganguli, David Gammack, Denise E. Kirschner. A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis. Mathematical Biosciences & Engineering, 2005, 2 (3) : 535-560. doi: 10.3934/mbe.2005.2.535

[17]

Dmitry Treschev. A locally integrable multi-dimensional billiard system. Discrete & Continuous Dynamical Systems - A, 2017, 37 (10) : 5271-5284. doi: 10.3934/dcds.2017228

[18]

Franz Achleitner, Anton Arnold, Eric A. Carlen. On multi-dimensional hypocoercive BGK models. Kinetic & Related Models, 2018, 11 (4) : 953-1009. doi: 10.3934/krm.2018038

[19]

Anatoli F. Ivanov. On global dynamics in a multi-dimensional discrete map. Conference Publications, 2015, 2015 (special) : 652-659. doi: 10.3934/proc.2015.0652

[20]

Gerald Sommer, Di Zang. Parity symmetry in multi-dimensional signals. Communications on Pure & Applied Analysis, 2007, 6 (3) : 829-852. doi: 10.3934/cpaa.2007.6.829

2018 Impact Factor: 1.313

Metrics

  • PDF downloads (6)
  • HTML views (0)
  • Cited by (0)

Other articles
by authors

[Back to Top]