# American Institute of Mathematical Sciences

March  2013, 8(1): 131-147. doi: 10.3934/nhm.2013.8.131

## Modeling contact inhibition of growth: Traveling waves

 1 Istituto per le Applicazioni del Calcolo Mauro Picone, CNR, University of Rome Tor Vergata, Via dei Taurini 19, 00185 Rome, Italy 2 Meiji Institute of Advanced Mathematical Sciences, Meiji University, 1-1-1, Higashi-mita, Tama-ku, Kawasaki, 214-8571 3 Department of Basic Sciences, Kyushu Institute of Technology, 1-1, Sensui-cho, Tobata, Kitakyuchu, 804-8550, Japan

Received  January 2012 Revised  October 2012 Published  April 2013

We consider a simplified 1-dimensional PDE-model describing the effect of contact inhibition in growth processes of normal and abnormal cells. Varying the value of a significant parameter, numerical tests suggest two different types of contact inhibition between the cell populations: the two populations move with constant velocity and exhibit spatial segregation, or they stop to move and regions of coexistence are formed. In order to understand the different mechanisms, we prove that there exists a segregated traveling wave solution for a unique wave speed, and we present numerical results on the stability" of the segregated waves. We conjecture the existence of a non-segregated standing wave for certain parameter values.
Citation: Michiel Bertsch, Masayasu Mimura, Tohru Wakasa. Modeling contact inhibition of growth: Traveling waves. Networks & Heterogeneous Media, 2013, 8 (1) : 131-147. doi: 10.3934/nhm.2013.8.131
##### References:
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##### References:
 [1] D. G. Aronson, Density-dependent interaction systems,, in, (1980), 161. Google Scholar [2] M. Bertsch, R. Dal Passo and M. Mimura, A free boundary problem arising in a simplified tumour growth model of contact inhibition,, Interfaces and Free Boundaries, 12 (2010), 235. doi: 10.4171/IFB/233. Google Scholar [3] M. Bertsch, D. Hilhorst, H. Izuhara and M. Mimura, A nonlinear parabolic-hyperbolic system for contact inhibition of cell-growth,, Differ. Equ. Appl., 4 (2012), 137. doi: 10.7153/dea-04-09. Google Scholar [4] M. Bertsch, D. Hilhorst, H. Izuhara, M. Mimura and T. Wakasa, Singular limit problem of a nonlinear parabolic-hyperbolic system for contact inhibition of cell-growth,, in preparation (2013)., (2013). doi: 10.7153/dea-04-09. Google Scholar [5] M. Bertsch, D. Hilhorst, H. Izuhara, M. Mimura and T. Wakasa, Traveling wave solutions of a parabolic-hyperbolic system for contact inhibition of cell-growth,, in preparation (2013)., (2013). Google Scholar [6] M. Bertsch, H. Izuhara, M. Mimura and T. Wakasa, in, preparation (2013)., (2013). Google Scholar [7] Z. Biró, Stability of traveling waves for degenerate reaction-diffusion equations of KPP-type,, Adv. Nonlinear Stud., 2 (2002), 357. Google Scholar [8] M. A. J. Chaplain, L. Graziano and L. Preziosi, Mathematical modelling of the loss of tissue compression responsiveness and its role in solid tumour deveropment,, Math. Med. Bio., 23 (2006), 197. doi: 10.1093/imammb/dql009. Google Scholar [9] E. A. Coddington and N. Levinson, "Theory of Ordinary Differential Equations,", McGraw-Hill, (1955). Google Scholar [10] R. A. Fisher, The wave of advance of advantageous genes,, Ann. Eugenics, 7 (1937), 335. doi: 10.1111/j.1469-1809.1937.tb02153.x. Google Scholar [11] G. Garcia-Ramos, F. Sanches-Garduño and P. K. Maini, Dispersal can sharpen parapatric boundaries on a spatially varying environment,, Ecology, 81 (2000), 749. Google Scholar [12] R. A. Gatenby and E. T. Gawlinski, A reaction-diffusion model of cancer invasion,, Cancer Res., 56 (1996), 5745. Google Scholar [13] B. Gilding and R. Kersner, "Travelling Waves in Nonlinear Diffusion-Convection Reaction,", Birkhäuser Verlag, (2004). doi: 10.1007/978-3-0348-7964-4. Google Scholar [14] D. Hilhorst, R. Kersner, E. Logak and M. Mimura, Interface dynamics of the Fisher equation with degenerate diffusion,, J. Differential Equations, 244 (2008), 2870. doi: 10.1016/j.jde.2008.02.018. Google Scholar [15] S. Kamin and P. Rosenau, Convergence to the travelling wave solution for a nonlinear reaction-diffusion equation,, Atti. Accad. Naz. Lincei Cl. Sci. Fis. Mat. Natur. Rend. Lincei Ser. 9 Mat. Appl., 15 (2004), 271. Google Scholar [16] N. S. Kolmogorov, N. Petrovsky and I. G. Piskunov, Étude de l'équation de la diffusion avec croissance de la quantité de matière e son application a un problème biologique, (Russian),, Bull. Univ. État Moscou, 1 (1937), 1. Google Scholar [17] G. S. Medvedev, K. Ono and P. Holmes, Traveling wave solutions of the degenerate Kolmogorov-Petrovsky-Piskunov equation,, European J. Appl. Math., 14 (2003), 343. doi: 10.1017/S0956792503005102. Google Scholar [18] J. A. Sherratt, Wave front propagation in a competition equation with a new motility term modelling contact inhibition between cell populations,, Proc. R. Soc. Lond. A, 456 (2000), 2365. doi: 10.1098/rspa.2000.0616. Google Scholar [19] F. Sanches-Garduño and P. K. Maini, Travelling wave phenomena in some degenerate reaction-diffusion equations,, J. Differential Equations, 117 (1995), 281. doi: 10.1006/jdeq.1995.1055. Google Scholar [20] Y. Tsukatani, K. Suzuki and K. Takahashi, Loss of density-dependent growth inhibition and dissociation of $\alpha$-catenin from E-cadherin,, J. Cell. Physiol., 173 (1997), 54. Google Scholar
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