The relative biologic effectiveness versus linear energy transfer
curve as an output-input relation for linear cellular systems
Quoc T. Luu - Department of Radiation Oncology, Stanford University, Stanford, CA 94305, United States (email)
Experiments have established that different radiation types have different magnitudes of biological response. When biological response is defined in terms of the Relative Biologic Effectiveness (RBE) and different radiation type is characterized by Linear Energy Transfer (LET), the plot of the RBE versus LET (RBE-LET) curve shows RBE to increase with increasing LET, to reach a maximum, and to decrease with further increasing LET. Perhaps due to the descriptive nature of biology, most quantitative models for the RBE-LET curve ignore the reality of the underlying molecular biology. On the other hand, the molecular basis for the RBE-LET curve is not completely known despite recent efforts.
Keywords: RBE-LET curve, systems biology, molecular radiation biology.
Received: September 2008; Accepted: December 2008; Published: June 2009.
2014 5-year IF1.128