Rotating antibiotics selects optimally against antibiotic resistance, in theory
Robert E. Beardmore - Department of Mathematics, Imperial College London, SW7 2AZ, London, United Kingdom (email)
The purpose of this paper is to use mathematical models to investigate the claim made in the medical literature over a decade ago that the routine rotation of antibiotics in an intensive care unit (ICU) will select against the evolution and spread of antibiotic-resistant pathogens. In contrast, previous theoretical studies addressing this question have demonstrated that routinely changing the drug of choice for a given pathogenic infection may in fact lead to a greater incidence of drug resistance in comparison to the random deployment of different drugs.
Keywords: Control theory, epidemiology, antibiotic rotation, drug resistance.
Received: September 2009; Accepted: March 2010; Published: June 2010.
2014 5-year IF1.128