Antibiotic cycling versus mixing: The difficulty of using mathematical
models to definitively quantify their relative merits
Robert E. Beardmore - Department of Mathematics, Imperial College London, SW7 2AZ, London, United Kingdom (email)
We ask the question Which antibiotic deployment protocols select best against drug-resistant microbes: mixing or periodic cycling? and demonstrate that the statistical distribution of the performances of both sets of protocols, mixing and periodic cycling, must have overlapping supports. In other words, it is a general, mathematical result that there must be mixing policies that outperform cycling policies and vice versa.
Keywords: Epidemiology, antibiotic cycling, antibiotic mixing, drug resistance.
Received: September 2010; Accepted: September 2010; Published: October 2010.
2010 Impact Factor1.180