An improved optimistic three-stage model for the spread of HIV
amongst injecting intravenous drug users
David Greenhalgh - Department of Mathematics and Statistics, University of Strathclyde, Livingstone Tower, 26 Richmond Street, Glasgow G1 1XH, United Kingdom (email) Abstract: We start off this paper with a brief introduction to modeling Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) amongst sharing, injecting drug users (IDUs). Then we describe the mathematical model which we shall use which extends an existing model of the spread of HIV and AIDS amongst IDUs by incorporating loss of HIV infectivity over time. This is followed by the derivation of a key epidemiological parameter, the basic reproduction number $sf(R)_0$. Next we give some analytical equilibrium, local and global stability results. We show that if $sf(R)_0 \le 1$ then the disease will always die out. For $sf(R)_0 > 1$ there is the disease-free equilibrium (DFE) and a unique endemic equilibrium. The DFE is unstable. An approximation argument shows that we expect the endemic equilibrium to be locally stable. We next discuss a more realistic version of the model, relaxing the assumption that the number of addicts remains constant and obtain some results for this model. The subsequent section gives simulations for both models confirming that if $sf(R)_0 \le 1$ then the disease will die out and if $sf(R)_0 > 1$ then if it is initially present the disease will tend to the unique endemic equilibrium. The simulation results are compared with the original model with no loss of HIV infectivity. Next the implications of these results for control strategies are considered. A brief summary concludes the paper.
Keywords: HIV/AIDS, Basic reproduction number, loss of infectivity, equilibrium and stability analysis, global stability
Received: July 2008; Revised: August 2009; Published: September 2009. |