## Journals

- Advances in Mathematics of Communications
- Big Data & Information Analytics
- Communications on Pure & Applied Analysis
- Discrete & Continuous Dynamical Systems - A
- Discrete & Continuous Dynamical Systems - B
- Discrete & Continuous Dynamical Systems - S
- Evolution Equations & Control Theory
- Inverse Problems & Imaging
- Journal of Computational Dynamics
- Journal of Dynamics & Games
- Journal of Geometric Mechanics
- Journal of Industrial & Management Optimization
- Journal of Modern Dynamics
- Kinetic & Related Models
- Mathematical Biosciences & Engineering
- Mathematical Control & Related Fields
- Mathematical Foundations of Computing
- Networks & Heterogeneous Media
- Numerical Algebra, Control & Optimization
- AIMS Mathematics
- Conference Publications
- Electronic Research Announcements
- Mathematics in Engineering

### Open Access Journals

For more information please click the “Full Text” above.

For more information please click the “Full Text” above.

*fold*and

*cusp*points is given. Examples illustrate the local behaviors of the flow near these singular points. Singularities of fold type correspond to the typical conjugate points as they arise for the classical problem of minimum surfaces of revolution in the calculus of variations and local optimality of trajectories ceases at fold points. Simple cusp points, on the other hand, generate a cut-locus that limits the optimality of close-by trajectories globally to times prior to the conjugate points.

Oncolytic viruses are genetically altered replication-competent vi-ruses which upon death of a cancer cell produce many new viruses that then infect neighboring tumor cells. A mathematical model for virotherapy of glioma is analyzed as a dynamical system for the case of constant viral infusions and TNF-*α* inhibitors. Aside from a tumor free equilibrium point, the system also has positive equilibrium point solutions. We investigate the number of equilibrium point solutions depending on the burst number, i.e., depending on the number of new viruses that are released from a dead cancer cell and then infect neighboring tumor cells. After a transcritical bifurcation with a positive equilibrium point solution, the tumor free equilibrium point becomes asymptotically stable and if the average viral load in the system lies above a threshold value related to the transcritical bifurcation parameter, the tumor size shrinks to zero exponentially. Other bifurcation events such as saddle-node and Hopf bifurcations are explored numerically.

## Year of publication

## Related Authors

## Related Keywords

[Back to Top]