We establish the existence of a positive solution for semilinear elliptic equation in exterior domains
$\begin{array}{lc}-Δ u + V(x) u = f(u),\ \ {\rm{in}} \ \ Ω \subseteq \mathbb{R}^N &&&(P_V)\end{array}$
where $N≥2$, $Ω$ is an open subset of $\mathbb{R}^N$ and $ \mathbb{R}^N \setminus Ω $ is bounded and not empty but there is no restriction on its size, nor any symmetry assumption. The nonlinear term $f$ is a non homogeneous, asymptotically linear or superlinear function at infinity. Moreover, the potential Ⅴ is a positive function, not necessarily symmetric. The existence of a solution is established in situations where this problem does not have a ground state.
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