February  2017, 37(2): 1109-1127. doi: 10.3934/dcds.2017046

Dynamics of spike in a Keller-Segel's minimal chemotaxis model

1. 

School of Mathematical Sciences, Shanxi University, Taiyuan, Shanxi 030006, China

2. 

Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA

3. 

Department of Mathematics, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China

4. 

Center for Financial Engineering, Soochow University, Suzhou, Jiangsu 215006, China

* Corresponding author: Yajing Zhang

Received  October 2014 Revised  March 2016 Published  November 2016

Fund Project: This work is partially supported by NSF DMS-1008905, NNSFC (No. 61374089), China Scholarship Council, NSF of Shanxi Province(No. 2014011005-2), Hundred Talent Program of Shanxi and International Cooperation Projects of Shanxi Province (No. 2014081026)

The dynamics are studied for the Keller-Segel's minimal chemotaxis model
$τ u_t=(u_x-kuv_x)_x, \ \ \ \ v_t=v_{xx}-v+u$
on a bounded interval with homogeneous Neumann boundary conditions, where
$\tau\geqslant 0$
and
$k\gg 1$
are parameters and the total mass of
$u$
is scaled to be one. In general, the dynamics can be divided into three stages: the first stage is very short in which
$u$
quickly becomes a delta like function with mass concentrated near the point of global maximum of
$v$
; in the second stage, the point of the global maximum of
$v$
drifts towards the boundary of the domain and reaches it at the end of the second stage; in the third stage, the profile of the solution evolves to a steady state profile. This paper considers a special case in which the relaxation parameter
$\tau$
is set to be zero, so the first stage takes no time. A free boundary problem describing the second stage is presented. Rigorous asymptotic behavior is proven for the third stage evolution.
Citation: Yajing Zhang, Xinfu Chen, Jianghao Hao, Xin Lai, Cong Qin. Dynamics of spike in a Keller-Segel's minimal chemotaxis model. Discrete & Continuous Dynamical Systems - A, 2017, 37 (2) : 1109-1127. doi: 10.3934/dcds.2017046
References:
[1]

N. AlikakosP. W. Bates and G. Fusco, Slow motion for the Cahn-Hilliard equation in one space dimension, J. Differ. Eqns., 90 (1991), 81-135. doi: 10.1016/0022-0396(91)90163-4.

[2]

P. W. Bates and J. Xun, Metastable patterns for the Cahn-Hilliard equation, Part Ⅰ, J. Differ. Eqns., 111 (1994), 421-457. doi: 10.1006/jdeq.1994.1089.

[3]

P. W. Bates and J. Xun, Metastable patterns for the Cahn-Hilliard equation, Part Ⅱ, J. Differ. Eqns., 117 (1995), 165-216. doi: 10.1006/jdeq.1995.1052.

[4]

P. Biler, Local and global solvability of some parabolic systems modelling chemotaxis, Adv. Math. Sci. Appl., 8 (1998), 715-743.

[5]

L. Bronsard and D. Hilhorst, On the slow dynamics for the Cahn-Hilliard equation in one space dimension, Proc. Roy. Soc. Lond., 439 (1992), 669-682. doi: 10.1098/rspa.1992.0176.

[6]

J. Carr and R. Pego, Metastable patterns in solutions of $u_t =\varepsilon ^2 u_{xx}- f(u)$, Comm. Pure Appl. Math., 42 (1989), 523-576. doi: 10.1002/cpa.3160420502.

[7]

X. Chen, Generation, propagation, and annihilation of metastable patterns, J. Differ. Eqns., 206 (2004), 399-437. doi: 10.1016/j.jde.2004.05.017.

[8]

X. ChenJ. HaoX. WangY. Wu and Y. Zhang, Stability of spiky solution of the Keller-Segel's minimal chemotaxis model, J. Differ. Eqns., 257 (2014), 3102-3134. doi: 10.1016/j.jde.2014.06.008.

[9]

X. Chen and M. Kowalczyk, Dynamics of an interior sipke in the Gierer-Meinhardt system, Siam J. Math. Anal., 33 (2001), 172-193. doi: 10.1137/S0036141099364954.

[10]

X. Chen and M. Kowalczyk, Slow dynamics of interior spikes in the Shadow Gierer-Meinhardt system, Adv. Differ. Eqns., 6 (2001), 847-872.

[11]

S. Childress, Chemotactic collapse in two dimensions, in Lecture Notes in Biomath. , 55, Springer, (1984), 61-66.

[12]

S. Childress and J. Perkus, Nonlinear aspects of chemotaxis, Math. Bios., 56 (1981), 217-237. doi: 10.1016/0025-5564(81)90055-9.

[13]

P. C. Fife and L. Hsiao, The generation and propagation of internal layers, Nonlinear Anal., 12 (1988), 19-41. doi: 10.1016/0362-546X(88)90010-7.

[14]

P. C. Fife and J. B. McLeod, The approach of solutions of nonlinear diffusion equations to traveling front solutions, Arch. Rational Mech. Anal., 65 (1977), 335-361. doi: 10.1007/BF00250432.

[15]

G. Fusco, A geometric approach to the dynamics of $u_t =\varepsilon ^2 u_{xx} +f(u)$ for small $\varepsilon $, in Problems Involving Change of Type, Springer, 359 (1990), 53-73.

[16]

G. Fusco and J. K. Hale, Slow motion manifolds, dormant instability and singular perturbations, J. Dyn. Diff. Eqns., 1 (1989), 75-94. doi: 10.1007/BF01048791.

[17]

H. GajewskiK. Zacharias and Dr. Konrad Gröger, Global behavior of a reaction-diffusion system modelling chemotaxis, Math. Nachr., 195 (1998), 77-114. doi: 10.1002/mana.19981950106.

[18]

M. Herrero and J. Velázquez, Singularity patterns in a chemotaxis model, Math. Ann., 306 (1996), 583-623. doi: 10.1007/BF01445268.

[19]

M. Herrero and J. Velázquez, Chemotaxis collapse for the Keller-Segel model, J. Math. Biol., 35 (1996), 177-194. doi: 10.1007/s002850050049.

[20]

T. Hillen and K. J. Painter, Global existence far a parabolic chemotaxis model with prevention of overcrowding, Adv. Appl. Math., 26 (2001), 280-301. doi: 10.1006/aama.2001.0721.

[21]

T. Hillen and K. J. Painter, A user's guide to PDE models for chemotaxis, J. Math. Biol., 58 (2009), 183-217. doi: 10.1007/s00285-008-0201-3.

[22]

T. Hillen and A. Potapov, The one-dimensional chemotaxis model: Global existence and asymptotic profile, Math. Meth. Appl. Sci., 27 (2004), 1783-1801. doi: 10.1002/mma.569.

[23]

D. Horstmann, From 1970 until now: The Keller-Segal model in chemotaxis and its consequences, Ⅰ, Jahresber. DMV, 105 (2003), 103-165.

[24]

D. Horstmann, From 1970 until now: The Keller-Segal model in chemotaxis and its consequences, Ⅱ, Jahresber. DMV, 106 (2004), 51-69.

[25]

W. Jäger and S. Luckhaus, On explosions of solutions to a system of partial differential equations modellingchemotaxis, Trans. Amer. Math. Soc., 329 (1992), 819-824. doi: 10.2307/2153966.

[26]

K. KangT. Kolokolnikov and M. J. Ward, The stability and dynamics of a spike in the one-dimensional Keller-Segel model, IMA J. Appl. Math., 72 (2007), 140-162. doi: 10.1093/imamat/hxl028.

[27]

E. Keller and L. Segel, Initiation of slime mold aggregation viewed as an instability, J. Theoret. Biol., 26 (1970), 399-415. doi: 10.1016/0022-5193(70)90092-5.

[28]

C.-S. LinW.-M. Ni and I. Takagi, Large amplitude stationary solutions to a chemotaxis system, J. Differ. Eqns., 72 (1988), 1-27. doi: 10.1016/0022-0396(88)90147-7.

[29]

T. Nagai, Blow-up of radially symmetric solutions to a chemotaxis system, Adv. Math. Sci. Appl., 5 (1995), 581-601.

[30]

T. NagaiT. Senba and K. Yoshida, Application of the Trudinger-Moser inequality to a parabolic system of chemotaxis, Funkcial. Ekvac., 40 (1997), 411-433.

[31]

T. Nagai, Blowup of nonradial solutions to parabolic-elliptic systems modeling chemotaxis in twodimensional domains, J. Inequal. Appl., 6 (2001), 37-55. doi: 10.1155/S1025583401000042.

[32]

W.-M. Ni and I. Takagi, Locating the peaks of least-energy solutions to a semilinear Neumann problem, Duke Math. J., 70 (1993), 247-281. doi: 10.1215/S0012-7094-93-07004-4.

[33]

K. Osaki and A. Yagi, Finite dimensional attractors for one dimensional Keller-Segel equations, Funkcial Ekvac., 44 (2001), 441-469.

[34]

C. S. Patlak, Random walk with persistence and external bias, Bull. Math. Biophys., 15 (1953), 311-338. doi: 10.1007/BF02476407.

[35]

T. Senba and T. Suzuki, Parabolic system of chemotaxis: Blowup in a finite and the infinite time, Methods Appl. Anal., 8 (2001), 349-367. doi: 10.4310/MAA.2001.v8.n2.a9.

[36]

X. Sun and M. J. Ward, Dynamics and coarsening of interfaces for the viscous Cahn-Hilliard equation in one spatial dimension, Stud. Appl. Math., 105 (2000), 203-234. doi: 10.1111/1467-9590.00149.

[37]

X. Wang and Q. Xu, Spiky and transition layer steady states of chemotaxis systems via global bifurcation and Helly compactness theorem, J. Math. Biol., 66 (2013), 1241-1266. doi: 10.1007/s00285-012-0533-x.

[38]

Y. ZhangX. ChenJ. HaoX. Lai and C. Qin, An eigenvalue problem arising from spiky steady states of a minimal chemotaxis model, J. Math. Anal. Appl., 420 (2014), 684-704. doi: 10.1016/j.jmaa.2014.06.005.

show all references

References:
[1]

N. AlikakosP. W. Bates and G. Fusco, Slow motion for the Cahn-Hilliard equation in one space dimension, J. Differ. Eqns., 90 (1991), 81-135. doi: 10.1016/0022-0396(91)90163-4.

[2]

P. W. Bates and J. Xun, Metastable patterns for the Cahn-Hilliard equation, Part Ⅰ, J. Differ. Eqns., 111 (1994), 421-457. doi: 10.1006/jdeq.1994.1089.

[3]

P. W. Bates and J. Xun, Metastable patterns for the Cahn-Hilliard equation, Part Ⅱ, J. Differ. Eqns., 117 (1995), 165-216. doi: 10.1006/jdeq.1995.1052.

[4]

P. Biler, Local and global solvability of some parabolic systems modelling chemotaxis, Adv. Math. Sci. Appl., 8 (1998), 715-743.

[5]

L. Bronsard and D. Hilhorst, On the slow dynamics for the Cahn-Hilliard equation in one space dimension, Proc. Roy. Soc. Lond., 439 (1992), 669-682. doi: 10.1098/rspa.1992.0176.

[6]

J. Carr and R. Pego, Metastable patterns in solutions of $u_t =\varepsilon ^2 u_{xx}- f(u)$, Comm. Pure Appl. Math., 42 (1989), 523-576. doi: 10.1002/cpa.3160420502.

[7]

X. Chen, Generation, propagation, and annihilation of metastable patterns, J. Differ. Eqns., 206 (2004), 399-437. doi: 10.1016/j.jde.2004.05.017.

[8]

X. ChenJ. HaoX. WangY. Wu and Y. Zhang, Stability of spiky solution of the Keller-Segel's minimal chemotaxis model, J. Differ. Eqns., 257 (2014), 3102-3134. doi: 10.1016/j.jde.2014.06.008.

[9]

X. Chen and M. Kowalczyk, Dynamics of an interior sipke in the Gierer-Meinhardt system, Siam J. Math. Anal., 33 (2001), 172-193. doi: 10.1137/S0036141099364954.

[10]

X. Chen and M. Kowalczyk, Slow dynamics of interior spikes in the Shadow Gierer-Meinhardt system, Adv. Differ. Eqns., 6 (2001), 847-872.

[11]

S. Childress, Chemotactic collapse in two dimensions, in Lecture Notes in Biomath. , 55, Springer, (1984), 61-66.

[12]

S. Childress and J. Perkus, Nonlinear aspects of chemotaxis, Math. Bios., 56 (1981), 217-237. doi: 10.1016/0025-5564(81)90055-9.

[13]

P. C. Fife and L. Hsiao, The generation and propagation of internal layers, Nonlinear Anal., 12 (1988), 19-41. doi: 10.1016/0362-546X(88)90010-7.

[14]

P. C. Fife and J. B. McLeod, The approach of solutions of nonlinear diffusion equations to traveling front solutions, Arch. Rational Mech. Anal., 65 (1977), 335-361. doi: 10.1007/BF00250432.

[15]

G. Fusco, A geometric approach to the dynamics of $u_t =\varepsilon ^2 u_{xx} +f(u)$ for small $\varepsilon $, in Problems Involving Change of Type, Springer, 359 (1990), 53-73.

[16]

G. Fusco and J. K. Hale, Slow motion manifolds, dormant instability and singular perturbations, J. Dyn. Diff. Eqns., 1 (1989), 75-94. doi: 10.1007/BF01048791.

[17]

H. GajewskiK. Zacharias and Dr. Konrad Gröger, Global behavior of a reaction-diffusion system modelling chemotaxis, Math. Nachr., 195 (1998), 77-114. doi: 10.1002/mana.19981950106.

[18]

M. Herrero and J. Velázquez, Singularity patterns in a chemotaxis model, Math. Ann., 306 (1996), 583-623. doi: 10.1007/BF01445268.

[19]

M. Herrero and J. Velázquez, Chemotaxis collapse for the Keller-Segel model, J. Math. Biol., 35 (1996), 177-194. doi: 10.1007/s002850050049.

[20]

T. Hillen and K. J. Painter, Global existence far a parabolic chemotaxis model with prevention of overcrowding, Adv. Appl. Math., 26 (2001), 280-301. doi: 10.1006/aama.2001.0721.

[21]

T. Hillen and K. J. Painter, A user's guide to PDE models for chemotaxis, J. Math. Biol., 58 (2009), 183-217. doi: 10.1007/s00285-008-0201-3.

[22]

T. Hillen and A. Potapov, The one-dimensional chemotaxis model: Global existence and asymptotic profile, Math. Meth. Appl. Sci., 27 (2004), 1783-1801. doi: 10.1002/mma.569.

[23]

D. Horstmann, From 1970 until now: The Keller-Segal model in chemotaxis and its consequences, Ⅰ, Jahresber. DMV, 105 (2003), 103-165.

[24]

D. Horstmann, From 1970 until now: The Keller-Segal model in chemotaxis and its consequences, Ⅱ, Jahresber. DMV, 106 (2004), 51-69.

[25]

W. Jäger and S. Luckhaus, On explosions of solutions to a system of partial differential equations modellingchemotaxis, Trans. Amer. Math. Soc., 329 (1992), 819-824. doi: 10.2307/2153966.

[26]

K. KangT. Kolokolnikov and M. J. Ward, The stability and dynamics of a spike in the one-dimensional Keller-Segel model, IMA J. Appl. Math., 72 (2007), 140-162. doi: 10.1093/imamat/hxl028.

[27]

E. Keller and L. Segel, Initiation of slime mold aggregation viewed as an instability, J. Theoret. Biol., 26 (1970), 399-415. doi: 10.1016/0022-5193(70)90092-5.

[28]

C.-S. LinW.-M. Ni and I. Takagi, Large amplitude stationary solutions to a chemotaxis system, J. Differ. Eqns., 72 (1988), 1-27. doi: 10.1016/0022-0396(88)90147-7.

[29]

T. Nagai, Blow-up of radially symmetric solutions to a chemotaxis system, Adv. Math. Sci. Appl., 5 (1995), 581-601.

[30]

T. NagaiT. Senba and K. Yoshida, Application of the Trudinger-Moser inequality to a parabolic system of chemotaxis, Funkcial. Ekvac., 40 (1997), 411-433.

[31]

T. Nagai, Blowup of nonradial solutions to parabolic-elliptic systems modeling chemotaxis in twodimensional domains, J. Inequal. Appl., 6 (2001), 37-55. doi: 10.1155/S1025583401000042.

[32]

W.-M. Ni and I. Takagi, Locating the peaks of least-energy solutions to a semilinear Neumann problem, Duke Math. J., 70 (1993), 247-281. doi: 10.1215/S0012-7094-93-07004-4.

[33]

K. Osaki and A. Yagi, Finite dimensional attractors for one dimensional Keller-Segel equations, Funkcial Ekvac., 44 (2001), 441-469.

[34]

C. S. Patlak, Random walk with persistence and external bias, Bull. Math. Biophys., 15 (1953), 311-338. doi: 10.1007/BF02476407.

[35]

T. Senba and T. Suzuki, Parabolic system of chemotaxis: Blowup in a finite and the infinite time, Methods Appl. Anal., 8 (2001), 349-367. doi: 10.4310/MAA.2001.v8.n2.a9.

[36]

X. Sun and M. J. Ward, Dynamics and coarsening of interfaces for the viscous Cahn-Hilliard equation in one spatial dimension, Stud. Appl. Math., 105 (2000), 203-234. doi: 10.1111/1467-9590.00149.

[37]

X. Wang and Q. Xu, Spiky and transition layer steady states of chemotaxis systems via global bifurcation and Helly compactness theorem, J. Math. Biol., 66 (2013), 1241-1266. doi: 10.1007/s00285-012-0533-x.

[38]

Y. ZhangX. ChenJ. HaoX. Lai and C. Qin, An eigenvalue problem arising from spiky steady states of a minimal chemotaxis model, J. Math. Anal. Appl., 420 (2014), 684-704. doi: 10.1016/j.jmaa.2014.06.005.

Figure 1.  A numerical solution of (1) with $\tau=0$, $k=200$, $\ell=1$, and mesh sizes $\Delta x=1/400$, $\Delta t=3\times 10^{-6}$. Left: snapshots of $v(k,\cdot,t)$ with constant frequency; middle: snapshots of $u$; right: location of the point of maximum of $v(k,\cdot,t)$, which reaches the boundary at $T\approx 0.13$.
Figure 2.  First Row: a numerical solution of (6) with $k=100$, $\ell=4$, and $v_0(x)=\frac{\ell}{\pi}\big|\cos\frac{\pi(x-2.5)}{\ell}\big|$; left is location of maximum of $v$; middle is snapshots of $v(k,\cdot,t)$ with non-uniform time elapses; right is snapshots of $v_x(k,\cdot,t)$. Second Row: the solution of the free boundary problem (7) for $t\in[0,T^-]$ ($T\approx 5.2$), combined with the solution of the boundary value problem (8) for $t\geqslant T$; left is the location of free boundary; middle is snapshots of $w$; right is snapshots of $w_x$.
[1]

Yuanyuan Liu, Youshan Tao. Asymptotic behavior in a chemotaxis-growth system with nonlinear production of signals. Discrete & Continuous Dynamical Systems - B, 2017, 22 (2) : 465-475. doi: 10.3934/dcdsb.2017021

[2]

Chiu-Ya Lan, Chi-Kun Lin. Asymptotic behavior of the compressible viscous potential fluid: Renormalization group approach. Discrete & Continuous Dynamical Systems - A, 2004, 11 (1) : 161-188. doi: 10.3934/dcds.2004.11.161

[3]

Marco Di Francesco, Alexander Lorz, Peter A. Markowich. Chemotaxis-fluid coupled model for swimming bacteria with nonlinear diffusion: Global existence and asymptotic behavior. Discrete & Continuous Dynamical Systems - A, 2010, 28 (4) : 1437-1453. doi: 10.3934/dcds.2010.28.1437

[4]

Cecilia Cavaterra, Maurizio Grasselli. Asymptotic behavior of population dynamics models with nonlocal distributed delays. Discrete & Continuous Dynamical Systems - A, 2008, 22 (4) : 861-883. doi: 10.3934/dcds.2008.22.861

[5]

Xiaoyan Lin, Yubo He, Xianhua Tang. Existence and asymptotic behavior of ground state solutions for asymptotically linear Schrödinger equation with inverse square potential. Communications on Pure & Applied Analysis, 2019, 18 (3) : 1547-1565. doi: 10.3934/cpaa.2019074

[6]

Kazuhiro Kurata, Kotaro Morimoto. Existence of multiple spike stationary patterns in a chemotaxis model with weak saturation. Discrete & Continuous Dynamical Systems - A, 2011, 31 (1) : 139-164. doi: 10.3934/dcds.2011.31.139

[7]

Tahir Bachar Issa, Rachidi Bolaji Salako. Asymptotic dynamics in a two-species chemotaxis model with non-local terms. Discrete & Continuous Dynamical Systems - B, 2017, 22 (10) : 3839-3874. doi: 10.3934/dcdsb.2017193

[8]

Domenica Borra, Tommaso Lorenzi. Asymptotic analysis of continuous opinion dynamics models under bounded confidence. Communications on Pure & Applied Analysis, 2013, 12 (3) : 1487-1499. doi: 10.3934/cpaa.2013.12.1487

[9]

Fengqi Yi, Hua Zhang, Alhaji Cherif, Wenying Zhang. Spatiotemporal patterns of a homogeneous diffusive system modeling hair growth: Global asymptotic behavior and multiple bifurcation analysis. Communications on Pure & Applied Analysis, 2014, 13 (1) : 347-369. doi: 10.3934/cpaa.2014.13.347

[10]

Zhipeng Qiu, Jun Yu, Yun Zou. The asymptotic behavior of a chemostat model. Discrete & Continuous Dynamical Systems - B, 2004, 4 (3) : 721-727. doi: 10.3934/dcdsb.2004.4.721

[11]

Shin-Ichiro Ei, Kota Ikeda, Yasuhito Miyamoto. Dynamics of a boundary spike for the shadow Gierer-Meinhardt system. Communications on Pure & Applied Analysis, 2012, 11 (1) : 115-145. doi: 10.3934/cpaa.2012.11.115

[12]

Aldana M. González Montoro, Ricardo Cao, Christel Faes, Geert Molenberghs, Nelson Espinosa, Javier Cudeiro, Jorge Mariño. Cross nearest-spike interval based method to measure synchrony dynamics. Mathematical Biosciences & Engineering, 2014, 11 (1) : 27-48. doi: 10.3934/mbe.2014.11.27

[13]

Simone Calogero, Juan Calvo, Óscar Sánchez, Juan Soler. Dispersive behavior in galactic dynamics. Discrete & Continuous Dynamical Systems - B, 2010, 14 (1) : 1-16. doi: 10.3934/dcdsb.2010.14.1

[14]

Martha Garlick, James Powell, David Eyre, Thomas Robbins. Mathematically modeling PCR: An asymptotic approximation with potential for optimization. Mathematical Biosciences & Engineering, 2010, 7 (2) : 363-384. doi: 10.3934/mbe.2010.7.363

[15]

Mykhailo Potomkin. Asymptotic behavior of thermoviscoelastic Berger plate. Communications on Pure & Applied Analysis, 2010, 9 (1) : 161-192. doi: 10.3934/cpaa.2010.9.161

[16]

Hunseok Kang. Asymptotic behavior of a discrete turing model. Discrete & Continuous Dynamical Systems - A, 2010, 27 (1) : 265-284. doi: 10.3934/dcds.2010.27.265

[17]

Shubo Zhao, Ping Liu, Mingchao Jiang. Stability and bifurcation analysis in a chemotaxis bistable growth system. Discrete & Continuous Dynamical Systems - S, 2017, 10 (5) : 1165-1174. doi: 10.3934/dcdss.2017063

[18]

Tomomi Yokota, Noriaki Yoshino. Existence of solutions to chemotaxis dynamics with logistic source. Conference Publications, 2015, 2015 (special) : 1125-1133. doi: 10.3934/proc.2015.1125

[19]

Doan Duy Hai, Atsushi Yagi. Longtime behavior of solutions to chemotaxis-proliferation model with three variables. Discrete & Continuous Dynamical Systems - A, 2012, 32 (11) : 3957-3974. doi: 10.3934/dcds.2012.32.3957

[20]

Moncef Aouadi, Taoufik Moulahi. Asymptotic analysis of a nonsimple thermoelastic rod. Discrete & Continuous Dynamical Systems - S, 2016, 9 (5) : 1475-1492. doi: 10.3934/dcdss.2016059

2017 Impact Factor: 1.179

Metrics

  • PDF downloads (24)
  • HTML views (3)
  • Cited by (0)

[Back to Top]