Analysis of a Cahn--Hilliard system with non-zero Dirichlet conditions modeling tumor growth with chemotaxis

Harald Garcke; Kei Fong Lam

doi:10.3934/dcds.2017183

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2017, Volume 37, Issue 8: 4277-4308. Doi: 10.3934/dcds.2017183

This issue Previous Article The geometric discretisation of the Suslov problem: A case study of consistency for nonholonomic integrators Next Article Orbital stability and uniqueness of the ground state for the non-linear Schrödinger equation in dimension one

Analysis of a Cahn--Hilliard system with non-zero Dirichlet conditions modeling tumor growth with chemotaxis

Harald Garcke and
Kei Fong Lam

Fakultät für Mathematik, Universität Regensburg, 93040 Regensburg, Germany

Received: April 2016

Revised: May 2017

Published: May 2017

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Abstract

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by healthy tissue. The well-posedness of the system equipped with Neumann boundary conditions was found to require regular potentials with quadratic growth. In this work, Dirichlet boundary conditions are considered, and we establish the well-posedness of the system for regular potentials with higher polynomial growth and also for singular potentials. New difficulties are encountered due to the higher polynomial growth, but for regular potentials, we retain the continuous dependence on initial and boundary data for the chemical potential and for the order parameter in strong norms as established in the previous work. Furthermore, we deduce the well-posedness of a variant of the model with quasi-static nutrient by rigorously passing to the limit where the ratio of the nutrient diffusion time-scale to the tumor doubling time-scale is small.

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Mathematics Subject Classification: Primary: 35D30, 35Q92, 35K57; Secondary: 35B40, 92C17.

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