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August  2017, 37(8): 4277-4308. doi: 10.3934/dcds.2017183

Analysis of a Cahn--Hilliard system with non-zero Dirichlet conditions modeling tumor growth with chemotaxis

 Fakultät für Mathematik, Universität Regensburg, 93040 Regensburg, Germany

Received  April 2016 Revised  May 2017 Published  April 2017

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by healthy tissue. The well-posedness of the system equipped with Neumann boundary conditions was found to require regular potentials with quadratic growth. In this work, Dirichlet boundary conditions are considered, and we establish the well-posedness of the system for regular potentials with higher polynomial growth and also for singular potentials. New difficulties are encountered due to the higher polynomial growth, but for regular potentials, we retain the continuous dependence on initial and boundary data for the chemical potential and for the order parameter in strong norms as established in the previous work. Furthermore, we deduce the well-posedness of a variant of the model with quasi-static nutrient by rigorously passing to the limit where the ratio of the nutrient diffusion time-scale to the tumor doubling time-scale is small.

Citation: Harald Garcke, Kei Fong Lam. Analysis of a Cahn--Hilliard system with non-zero Dirichlet conditions modeling tumor growth with chemotaxis. Discrete & Continuous Dynamical Systems - A, 2017, 37 (8) : 4277-4308. doi: 10.3934/dcds.2017183
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References:
 [1] Alain Miranville, Sergey Zelik. The Cahn-Hilliard equation with singular potentials and dynamic boundary conditions. Discrete & Continuous Dynamical Systems - A, 2010, 28 (1) : 275-310. doi: 10.3934/dcds.2010.28.275 [2] Pierluigi Colli, Gianni Gilardi, Elisabetta Rocca, Jürgen Sprekels. Asymptotic analyses and error estimates for a Cahn-Hilliard type phase field system modelling tumor growth. Discrete & Continuous Dynamical Systems - S, 2017, 10 (1) : 37-54. doi: 10.3934/dcdss.2017002 [3] Andrea Signori. Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme. Mathematical Control & Related Fields, 2020, 10 (2) : 305-331. doi: 10.3934/mcrf.2019040 [4] Pierluigi Colli, Gianni Gilardi, Danielle Hilhorst. On a Cahn-Hilliard type phase field system related to tumor growth. Discrete & Continuous Dynamical Systems - A, 2015, 35 (6) : 2423-2442. doi: 10.3934/dcds.2015.35.2423 [5] Gianni Gilardi, A. Miranville, Giulio Schimperna. On the Cahn-Hilliard equation with irregular potentials and dynamic boundary conditions. Communications on Pure & Applied Analysis, 2009, 8 (3) : 881-912. doi: 10.3934/cpaa.2009.8.881 [6] Zhenhua Zhang. Asymptotic behavior of solutions to the phase-field equations with neumann boundary conditions. Communications on Pure & Applied Analysis, 2005, 4 (3) : 683-693. doi: 10.3934/cpaa.2005.4.683 [7] Laurence Cherfils, Madalina Petcu, Morgan Pierre. A numerical analysis of the Cahn-Hilliard equation with dynamic boundary conditions. Discrete & Continuous Dynamical Systems - A, 2010, 27 (4) : 1511-1533. doi: 10.3934/dcds.2010.27.1511 [8] Michele Colturato. Well-posedness and longtime behavior for a singular phase field system with perturbed phase dynamics. Evolution Equations & Control Theory, 2018, 7 (2) : 217-245. doi: 10.3934/eect.2018011 [9] Sergey Zelik, Jon Pennant. Global well-posedness in uniformly local spaces for the Cahn-Hilliard equation in $\mathbb{R}^3$. Communications on Pure & Applied Analysis, 2013, 12 (1) : 461-480. doi: 10.3934/cpaa.2013.12.461 [10] Jan Prüss, Vicente Vergara, Rico Zacher. Well-posedness and long-time behaviour for the non-isothermal Cahn-Hilliard equation with memory. Discrete & Continuous Dynamical Systems - A, 2010, 26 (2) : 625-647. doi: 10.3934/dcds.2010.26.625 [11] Barbara Kaltenbacher, Irena Lasiecka. Well-posedness of the Westervelt and the Kuznetsov equation with nonhomogeneous Neumann boundary conditions. Conference Publications, 2011, 2011 (Special) : 763-773. doi: 10.3934/proc.2011.2011.763 [12] Alain Miranville, Wafa Saoud, Raafat Talhouk. On the Cahn-Hilliard/Allen-Cahn equations with singular potentials. Discrete & Continuous Dynamical Systems - B, 2019, 24 (8) : 3633-3651. doi: 10.3934/dcdsb.2018308 [13] Fujun Zhou, Shangbin Cui. Well-posedness and stability of a multidimensional moving boundary problem modeling the growth of tumor cord. Discrete & Continuous Dynamical Systems - A, 2008, 21 (3) : 929-943. doi: 10.3934/dcds.2008.21.929 [14] Maurizio Grasselli, Alain Miranville, Giulio Schimperna. The Caginalp phase-field system with coupled dynamic boundary conditions and singular potentials. Discrete & Continuous Dynamical Systems - A, 2010, 28 (1) : 67-98. doi: 10.3934/dcds.2010.28.67 [15] Ciprian G. Gal, Maurizio Grasselli. Singular limit of viscous Cahn-Hilliard equations with memory and dynamic boundary conditions. Discrete & Continuous Dynamical Systems - B, 2013, 18 (6) : 1581-1610. doi: 10.3934/dcdsb.2013.18.1581 [16] Ciprian G. Gal, Hao Wu. Asymptotic behavior of a Cahn-Hilliard equation with Wentzell boundary conditions and mass conservation. Discrete & Continuous Dynamical Systems - A, 2008, 22 (4) : 1041-1063. doi: 10.3934/dcds.2008.22.1041 [17] Joachim Escher, Anca-Voichita Matioc. Well-posedness and stability analysis for a moving boundary problem modelling the growth of nonnecrotic tumors. Discrete & Continuous Dynamical Systems - B, 2011, 15 (3) : 573-596. doi: 10.3934/dcdsb.2011.15.573 [18] Kentarou Fujie. Global asymptotic stability in a chemotaxis-growth model for tumor invasion. Discrete & Continuous Dynamical Systems - S, 2020, 13 (2) : 203-209. doi: 10.3934/dcdss.2020011 [19] Maxim A. Olshanskii, Leo G. Rebholz, Abner J. Salgado. On well-posedness of a velocity-vorticity formulation of the stationary Navier-Stokes equations with no-slip boundary conditions. Discrete & Continuous Dynamical Systems - A, 2018, 38 (7) : 3459-3477. doi: 10.3934/dcds.2018148 [20] Daniel Coutand, J. Peirce, Steve Shkoller. Global well-posedness of weak solutions for the Lagrangian averaged Navier-Stokes equations on bounded domains. Communications on Pure & Applied Analysis, 2002, 1 (1) : 35-50. doi: 10.3934/cpaa.2002.1.35

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