Penalisation of long treatment time and optimal control of a tumour growth model of Cahn–Hilliard type with singular potential

Andrea Signori

doi:10.3934/dcds.2020373

Article Contents

2021, Volume 41, Issue 6: 2519-2542. Doi: 10.3934/dcds.2020373

This issue Previous Article Next Article Comparison theorem for diagonally quadratic BSDEs

Penalisation of long treatment time and optimal control of a tumour growth model of Cahn–Hilliard type with singular potential

Andrea Signori

Dipartimento di Matematica e Applicazioni, Università di Milano-Bicocca, via Cozzi 55, 20125 Milano, Italy

Received: May 2020

Revised: September 2020

Early access: November 2020

Published: June 2021

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Abstract

A distributed optimal control problem for a diffuse interface model, which physical context is that of tumour growth dynamics, is addressed. The system we deal with comprises a Cahn–Hilliard equation for the tumour fraction coupled with a reaction-diffusion for a nutrient species surrounding the tumourous cells. The cost functional to be minimised possesses some objective terms and it also penalises long treatments time, which may affect harm to the patients, and big aggregations of tumourous cells. Hence, the optimisation problem leads to the optimal strategy which reduces the time exposure of the patient to the medication and at the same time allows the doctors to achieve suitable clinical goals.

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Mathematics Subject Classification: Primary: 35Q92, 49J20, 49K20; Secondary: 35K86, 92C50.

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