# American Institute of Mathematical Sciences

September  2021, 41(9): 4065-4083. doi: 10.3934/dcds.2021028

## Global generalized solutions to a chemotaxis model of capillary-sprout growth during tumor angiogenesis

 School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an, Shaanxi, 710129, P. R. China

* Corresponding author: Xueli Bai

Received  August 2020 Revised  December 2020 Published  September 2021 Early access  January 2021

This paper considers a chemotaxis-convection model of capillary-sprout growth during tumor angiogenesis
 $\begin{equation*} \begin{split} \left\{ {\begin{array}{*{20}{l}} {{u_t} = \Delta u - \nabla \cdot (u\nabla v) + \nabla \cdot (u\nabla w),}&{x \in \Omega ,t > 0,} \\ {{v_t} = \Delta v + \nabla \cdot (v\nabla w) - v + u,}&{x \in \Omega ,t > 0,} \\ {0 = \Delta w - w + u,}&{x \in \Omega ,t > 0,} \end{array}} \right. \end{split} \end{equation*}$
under Neumann initial-boundary conditions in a smooth bounded domain. In the two-dimensional setting, introducing a generalized solution concept according to (Winkler, 2015 [35]) and constructing an appropriate regularized system, we prove the global existence of at least one such solution with suitably regular initial data by an approximation procedure. To overcome the difficulty in taking the limit to its regularized system, we establish some technical estimates related to several energy integrals with special structures like
 $\int_0^T\int_{\Omega}{\frac{{{u_\varepsilon }v_\varepsilon^p}}{{1 +\varepsilon {u_\varepsilon }}}}$
,
 $p>1$
and
 $\int_0^T \int_\Omega {\frac{{{u_\varepsilon }}}{{1+\varepsilon {u_\varepsilon }}}\ln^{k}({u_\varepsilon } + 1)}dxdt$
,
 $k\in(1,2)$
.
Citation: Xueli Bai, Wenji Zhang. Global generalized solutions to a chemotaxis model of capillary-sprout growth during tumor angiogenesis. Discrete & Continuous Dynamical Systems, 2021, 41 (9) : 4065-4083. doi: 10.3934/dcds.2021028
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