This work is devoted to a study of a compressible generic two-fluid model with possibly unequal velocities for arbitrarily large initial data. This model can describe some interesting physical phenomena, such as counter-current flow in which two fluids move in opposite direction. Less is known about the global existence and uniqueness of large solutions. Even for the one-fluid model, it is still open when the adiabatic parameter belongs to $ (1, \frac{3}{2}] $. The degeneracy of viscosities and the non-conservative form of the pressure terms due to unequal velocities are the main issues. In this work, we obtain the global existence and uniqueness of the solution for arbitrarily large initial data via applying the two-fluid effective velocities to a decomposition of implicit pressure functions and deriving a series of new global a priori $ L^p $ estimates of both velocities and effective velocities. The adiabatic parameters are allowed to be bigger than 1.
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