American Institute of Mathematical Sciences

February  2001, 1(1): 43-59. doi: 10.3934/dcdsb.2001.1.43

Cell death and the maintenance of immunological memory

 1 Immunobiology Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, United Kingdom, United Kingdom

Revised  January 2001 Published  January 2001

Immunological memory is found in diverse populations of a class of lymphocytes called T cells, that are held at roughly constant numbers. Its composition is in continuous flux as we encounter new pathogens and cells are lost. The mechanisms which preserve the memory T cell population in the face of these uncertain factors are largely unknown. We propose a mechanism for homeostasis, driven by density-dependent cell death, that both fits experimental data and naturally preserves the clonal composition of the T cell pool with fluctuating cell numbers. It also provides clues as to the source of differences in diversity between T cell memory subpopulations.
Citation: Andrew Yates, Robin Callard. Cell death and the maintenance of immunological memory. Discrete & Continuous Dynamical Systems - B, 2001, 1 (1) : 43-59. doi: 10.3934/dcdsb.2001.1.43
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