February  2001, 1(1): 43-59. doi: 10.3934/dcdsb.2001.1.43

Cell death and the maintenance of immunological memory


Immunobiology Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, United Kingdom, United Kingdom

Revised  January 2001 Published  January 2001

Immunological memory is found in diverse populations of a class of lymphocytes called T cells, that are held at roughly constant numbers. Its composition is in continuous flux as we encounter new pathogens and cells are lost. The mechanisms which preserve the memory T cell population in the face of these uncertain factors are largely unknown. We propose a mechanism for homeostasis, driven by density-dependent cell death, that both fits experimental data and naturally preserves the clonal composition of the T cell pool with fluctuating cell numbers. It also provides clues as to the source of differences in diversity between T cell memory subpopulations.
Citation: Andrew Yates, Robin Callard. Cell death and the maintenance of immunological memory. Discrete & Continuous Dynamical Systems - B, 2001, 1 (1) : 43-59. doi: 10.3934/dcdsb.2001.1.43

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