T cell sensitivity and specificity - kinetic proofreading revisited

Cliburn Chan; Andrew J.T. George; Jaroslav Stark

doi:10.3934/dcdsb.2003.3.343

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2003, Volume 3, Issue 3: 343-360. Doi: 10.3934/dcdsb.2003.3.343

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T cell sensitivity and specificity - kinetic proofreading revisited

1.
Department of Immunology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN
2.
Department of Mathematics, Imperial College London, 180 Queen's Gate, London SW7 2BZ

Received: May 31, 2002

Revised: January 31, 2003

Published: July 2003

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Abstract

T cells recognise foreign antigen presented by antigen presenting cells at extremely low concentrations, and are able to discriminate between different ligands with high specificity. McKeithan's kinetic proofreading model is often invoked to explain this sensitivity and specificity of the T cell. In this paper, we analyse the strengths and limitations of this model, and suggest that it does not seem adequate to explain the observed degree of T cell sensitivity, specificity and robustness.

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Mathematics Subject Classification: 92B05, 92C45.

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