February  2004, 4(1): 161-186. doi: 10.3934/dcdsb.2004.4.161

Modelling cell populations with spatial structure: Steady state and treatment-induced evolution


Istituto di Analisi dei Sistemi ed Informatica "A. Ruberti" - CNR, Viale Manzoni 30, 00185 Roma, Italy, Italy


European Institute of Oncology, Division of Epidemiology and Biostatistics, Via Ripamonti 435, 20141 Milano, Italy


Dipartimento di Matematica "U. Dini", Università di Firenze, Viale Morgagni 67/A, 50134 Firenze, Italy

Received  December 2002 Revised  May 2003 Published  November 2003

Tumour cells growing around blood vessels form structures called tumour cords. We review some mathematical models that have been proposed to describe the stationary state of the cord and the cord evolution after single-dose cell killing treatment. Whereas the cell population has been represented with age or maturity structure to describe the cord stationary state, for the response to treatment a simpler approach was followed, by representing the cell population by means of the cell volume fractions. In this latter model, where transport of oxygen is included and its concentration is critical for cell viability, some constraints to be imposed on the interface separating the tumour from the necrotic region have a crucial role. An analysis of experimental data from untreated tumour cords, which involves modelling by cell age and by volume fractions, and some results about the cord response to impulsive cell killing, are also presented.
Citation: Alessandro Bertuzzi, Alberto d'Onofrio, Antonio Fasano, Alberto Gandolfi. Modelling cell populations with spatial structure: Steady state and treatment-induced evolution. Discrete & Continuous Dynamical Systems - B, 2004, 4 (1) : 161-186. doi: 10.3934/dcdsb.2004.4.161

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