American Institute of Mathematical Sciences

Advanced
May  2004, 4(2): 479-495. doi: 10.3934/dcdsb.2004.4.479

An epidemiology model that includes a leaky vaccine with a general waning function

Julien Arino 1, , K.L. Cooke 2, , P. van den Driessche 1, and  J. Velasco-Hernández 3,

1. 

Department of Mathematics and Statistics, University of Victoria, Victoria B.C., Canada V8W 3P4, Canada, Canada
2. 

Department of Mathematics, Pomona College, Claremont, CA 91711-6348, United States
3. 

Programa de Matemáticas Aplicadas y Computación, Instituto Mexicano del Petróleo, Eje Central Lázaro Cárdenas 152, San Bartolo Atepehuacan, D.F. 07730, Mexico

Received  December 2002 Revised  August 2003 Published  February 2004

Vaccination that gives partial protection for both newborns and susceptibles is included in a transmission model for a disease that confers no immunity. A general form of the vaccine waning function is assumed, and the interplay of this together with the vaccine efficacy and vaccination rates is discussed. The integro-differential system describing the model is studied for a constant vaccine waning rate, in which case it reduces to an ODE system, and for a constant waning period, in which case it reduces to a system of delay differential equations. For some parameter values, the model is shown to exhibit a backward bifurcation, leading to the existence of subthreshold endemic equilibria. Numerical examples are presented that demonstrate the consequence of this bifurcation in terms of epidemic control. The model can alternatively be interpreted as one consisting of two social groups, with education playing the role of vaccination.
Keywords: vaccination, Epidemic model, delay differential equation system., backward bifurcation.
Mathematics Subject Classification: 92D30, 34K18, 34K2.
Citation: Julien Arino, K.L. Cooke, P. van den Driessche, J. Velasco-Hernández. An epidemiology model that includes a leaky vaccine with a general waning function. Discrete and Continuous Dynamical Systems - B, 2004, 4 (2) : 479-495. doi: 10.3934/dcdsb.2004.4.479
[1]

Xiaomei Feng, Zhidong Teng, Kai Wang, Fengqin Zhang. Backward bifurcation and global stability in an epidemic model with treatment and vaccination. Discrete and Continuous Dynamical Systems - B, 2014, 19 (4) : 999-1025. doi: 10.3934/dcdsb.2014.19.999
[2]

Linda J. S. Allen, P. van den Driessche. Stochastic epidemic models with a backward bifurcation. Mathematical Biosciences & Engineering, 2006, 3 (3) : 445-458. doi: 10.3934/mbe.2006.3.445
[3]

Benjamin H. Singer, Denise E. Kirschner. Influence of backward bifurcation on interpretation of $R_0$ in a model of epidemic tuberculosis with reinfection. Mathematical Biosciences & Engineering, 2004, 1 (1) : 81-93. doi: 10.3934/mbe.2004.1.81
[4]

Muntaser Safan, Klaus Dietz. On the eradicability of infections with partially protective vaccination in models with backward bifurcation. Mathematical Biosciences & Engineering, 2009, 6 (2) : 395-407. doi: 10.3934/mbe.2009.6.395
[5]

Tomás Caraballo, Renato Colucci, Luca Guerrini. Bifurcation scenarios in an ordinary differential equation with constant and distributed delay: A case study. Discrete and Continuous Dynamical Systems - B, 2019, 24 (6) : 2639-2655. doi: 10.3934/dcdsb.2018268
[6]

Qianqian Cui, Zhipeng Qiu, Ling Ding. An SIR epidemic model with vaccination in a patchy environment. Mathematical Biosciences & Engineering, 2017, 14 (5&6) : 1141-1157. doi: 10.3934/mbe.2017059
[7]

Urszula Foryś, Jan Poleszczuk. A delay-differential equation model of HIV related cancer--immune system dynamics. Mathematical Biosciences & Engineering, 2011, 8 (2) : 627-641. doi: 10.3934/mbe.2011.8.627
[8]

Siyang Cai, Yongmei Cai, Xuerong Mao. A stochastic differential equation SIS epidemic model with regime switching. Discrete and Continuous Dynamical Systems - B, 2021, 26 (9) : 4887-4905. doi: 10.3934/dcdsb.2020317
[9]

Shujing Gao, Dehui Xie, Lansun Chen. Pulse vaccination strategy in a delayed sir epidemic model with vertical transmission. Discrete and Continuous Dynamical Systems - B, 2007, 7 (1) : 77-86. doi: 10.3934/dcdsb.2007.7.77
[10]

Geni Gupur, Xue-Zhi Li. Global stability of an age-structured SIRS epidemic model with vaccination. Discrete and Continuous Dynamical Systems - B, 2004, 4 (3) : 643-652. doi: 10.3934/dcdsb.2004.4.643
[11]

Aili Wang, Yanni Xiao, Robert A. Cheke. Global dynamics of a piece-wise epidemic model with switching vaccination strategy. Discrete and Continuous Dynamical Systems - B, 2014, 19 (9) : 2915-2940. doi: 10.3934/dcdsb.2014.19.2915
[12]

Bing Zeng, Pei Yu. A hierarchical parametric analysis on Hopf bifurcation of an epidemic model. Discrete and Continuous Dynamical Systems - S, 2022  doi: 10.3934/dcdss.2022069
[13]

Sumei Li, Yicang Zhou. Backward bifurcation of an HTLV-I model with immune response. Discrete and Continuous Dynamical Systems - B, 2016, 21 (3) : 863-881. doi: 10.3934/dcdsb.2016.21.863
[14]

Zhigui Lin, Yinan Zhao, Peng Zhou. The infected frontier in an SEIR epidemic model with infinite delay. Discrete and Continuous Dynamical Systems - B, 2013, 18 (9) : 2355-2376. doi: 10.3934/dcdsb.2013.18.2355
[15]

Ying Hu, Shanjian Tang. Switching game of backward stochastic differential equations and associated system of obliquely reflected backward stochastic differential equations. Discrete and Continuous Dynamical Systems, 2015, 35 (11) : 5447-5465. doi: 10.3934/dcds.2015.35.5447
[16]

Xin Zhao, Tao Feng, Liang Wang, Zhipeng Qiu. Threshold dynamics and sensitivity analysis of a stochastic semi-Markov switched SIRS epidemic model with nonlinear incidence and vaccination. Discrete and Continuous Dynamical Systems - B, 2021, 26 (12) : 6131-6154. doi: 10.3934/dcdsb.2021010
[17]

Xiao Wang, Zhaohui Yang, Xiongwei Liu. Periodic and almost periodic oscillations in a delay differential equation system with time-varying coefficients. Discrete and Continuous Dynamical Systems, 2017, 37 (12) : 6123-6138. doi: 10.3934/dcds.2017263
[18]

Eugen Stumpf. On a delay differential equation arising from a car-following model: Wavefront solutions with constant-speed and their stability. Discrete and Continuous Dynamical Systems - B, 2017, 22 (9) : 3317-3340. doi: 10.3934/dcdsb.2017139
[19]

Radosław Kurek, Paweł Lubowiecki, Henryk Żołądek. The Hess-Appelrot system. Ⅲ. Splitting of separatrices and chaos. Discrete and Continuous Dynamical Systems, 2018, 38 (4) : 1955-1981. doi: 10.3934/dcds.2018079
[20]

Eugenii Shustin. Exponential decay of oscillations in a multidimensional delay differential system. Conference Publications, 2003, 2003 (Special) : 809-816. doi: 10.3934/proc.2003.2003.809

2020 Impact Factor: 1.327

Tools

Metrics

  • PDF downloads (173)
  • HTML views (0)
  • Cited by (18)

Other articles
by authors

[Back to Top]

Copyright © 2022 American Institute of Mathematical Sciences | Privacy Policy