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July  2008, 10(1): 129-148. doi: 10.3934/dcdsb.2008.10.129

Resilience in stem cell renewal: development of the Agur--Daniel--Ginosar model

Oleg U. Kirnasovsky 1, , Yuri Kogan 1, and  Zvia Agur 1,

1. 

Institute for Medical Biomathematics (IMBM), 10 Hate'ena St., P.O. Box 282, 60991, Bene Ataroth, Israel, Israel

Published  April 2008

This work is based on a previous model of Z. Agur, Y. Daniel and Y. Ginosar (2002), retrieving the essential properties of homeostatic tissue development, as reflected by the bone marrow. The original model, represented by cellular automata on a connected, locally finite undirected graph, identifies the minimal basic properties essential for maintaining tissue homeostasis and for guaranteeing the ability of a few stem cells to repopulate the tissue following its depletion. However, this model is too general to ensure a relative “stability” of stem cell numbers in the tissue, a prerequisite for the integrity of biological systems. In the present work, some natural limitations on the model are introduced, under which a formula for the state of a given cell at any given time is obtained, as well as for the proportion of stem cells as a function of model parameters. For tube-like graphs, defined for modeling tissue engineering scaffolds and known tumor geometries, the system obtains a fixed cellular composition, interpreted as homeostasis, thus enabling precise calculation of the necessary conditions for tissue reconstruction. These results also can shed light on conditions for disrupting homeostasis in cancerous tissues.
Keywords: cancer therapy., cellular automata, Graph theory, biological model.
Mathematics Subject Classification: 00A71, 05C90, 92C37, 92D25, 94C1.
Citation: Oleg U. Kirnasovsky, Yuri Kogan, Zvia Agur. Resilience in stem cell renewal: development of the Agur--Daniel--Ginosar model. Discrete and Continuous Dynamical Systems - B, 2008, 10 (1) : 129-148. doi: 10.3934/dcdsb.2008.10.129
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