American Institute of Mathematical Sciences

Advanced
September  2009, 12(2): 261-277. doi: 10.3934/dcdsb.2009.12.261

Predicting the drug release kinetics of matrix tablets

Boris Baeumer 1, , Lipika Chatterjee 2, , Peter Hinow 3, , Thomas Rades 2, , Ami Radunskaya 4, and  Ian Tucker 2,

1. 

Department of Mathematics and Statistics, University of Otago, Dunedin, New Zealand
2. 

New Zealand's National School of Pharmacy, University of Otago, Dunedin, New Zealand, New Zealand, New Zealand
3. 

Institute for Mathematics and its Applications, University of Minnesota, 114 Lind Hall, Minneapolis, MN 55455
4. 

Department of Mathematics, Pomona College, 610 N. College Ave., Claremont, CA 91711

Received  October 2008 Revised  April 2009 Published  July 2009

In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.
Keywords: Matrix tablets, mathematical modeling., drug release kinetics.
Mathematics Subject Classification: Primary: 92C5.
Citation: Boris Baeumer, Lipika Chatterjee, Peter Hinow, Thomas Rades, Ami Radunskaya, Ian Tucker. Predicting the drug release kinetics of matrix tablets. Discrete & Continuous Dynamical Systems - B, 2009, 12 (2) : 261-277. doi: 10.3934/dcdsb.2009.12.261
[1]

Urszula Ledzewicz, Shuo Wang, Heinz Schättler, Nicolas André, Marie Amélie Heng, Eddy Pasquier. On drug resistance and metronomic chemotherapy: A mathematical modeling and optimal control approach. Mathematical Biosciences & Engineering, 2017, 14 (1) : 217-235. doi: 10.3934/mbe.2017014
[2]

Lambertus A. Peletier. Modeling drug-protein dynamics. Discrete & Continuous Dynamical Systems - S, 2012, 5 (1) : 191-207. doi: 10.3934/dcdss.2012.5.191
[3]

Carole Guillevin, Rémy Guillevin, Alain Miranville, Angélique Perrillat-Mercerot. Analysis of a mathematical model for brain lactate kinetics. Mathematical Biosciences & Engineering, 2018, 15 (5) : 1225-1242. doi: 10.3934/mbe.2018056
[4]

Robert P. Gilbert, Philippe Guyenne, Ying Liu. Modeling of the kinetics of vitamin D$_3$ in osteoblastic cells. Mathematical Biosciences & Engineering, 2013, 10 (2) : 319-344. doi: 10.3934/mbe.2013.10.319
[5]

Cristian Tomasetti, Doron Levy. An elementary approach to modeling drug resistance in cancer. Mathematical Biosciences & Engineering, 2010, 7 (4) : 905-918. doi: 10.3934/mbe.2010.7.905
[6]

Patrice Bertail, Stéphan Clémençon, Jessica Tressou. A storage model with random release rate for modeling exposure to food contaminants. Mathematical Biosciences & Engineering, 2008, 5 (1) : 35-60. doi: 10.3934/mbe.2008.5.35
[7]

Avner Friedman, Wenrui Hao. Mathematical modeling of liver fibrosis. Mathematical Biosciences & Engineering, 2017, 14 (1) : 143-164. doi: 10.3934/mbe.2017010
[8]

Nicolas Bacaër, Cheikh Sokhna. A reaction-diffusion system modeling the spread of resistance to an antimalarial drug. Mathematical Biosciences & Engineering, 2005, 2 (2) : 227-238. doi: 10.3934/mbe.2005.2.227
[9]

A. Chauviere, L. Preziosi, T. Hillen. Modeling the motion of a cell population in the extracellular matrix. Conference Publications, 2007, 2007 (Special) : 250-259. doi: 10.3934/proc.2007.2007.250
[10]

Gang Bao. Mathematical modeling of nonlinear diffracvtive optics. Conference Publications, 1998, 1998 (Special) : 89-99. doi: 10.3934/proc.1998.1998.89
[11]

Cristian Dobre. Mathematical properties of the regular *-representation of matrix $*$-algebras with applications to semidefinite programming. Numerical Algebra, Control & Optimization, 2013, 3 (2) : 367-378. doi: 10.3934/naco.2013.3.367
[12]

Baba Issa Camara, Houda Mokrani, Evans K. Afenya. Mathematical modeling of glioma therapy using oncolytic viruses. Mathematical Biosciences & Engineering, 2013, 10 (3) : 565-578. doi: 10.3934/mbe.2013.10.565
[13]

Karly Jacobsen, Jillian Stupiansky, Sergei S. Pilyugin. Mathematical modeling of citrus groves infected by huanglongbing. Mathematical Biosciences & Engineering, 2013, 10 (3) : 705-728. doi: 10.3934/mbe.2013.10.705
[14]

Bashar Ibrahim. Mathematical analysis and modeling of DNA segregation mechanisms. Mathematical Biosciences & Engineering, 2018, 15 (2) : 429-440. doi: 10.3934/mbe.2018019
[15]

Natalia L. Komarova. Mathematical modeling of cyclic treatments of chronic myeloid leukemia. Mathematical Biosciences & Engineering, 2011, 8 (2) : 289-306. doi: 10.3934/mbe.2011.8.289
[16]

Jeong-Mi Yoon, Volodymyr Hrynkiv, Lisa Morano, Anh Tuan Nguyen, Sara Wilder, Forrest Mitchell. Mathematical modeling of Glassy-winged sharpshooter population. Mathematical Biosciences & Engineering, 2014, 11 (3) : 667-677. doi: 10.3934/mbe.2014.11.667
[17]

Evans K. Afenya. Using Mathematical Modeling as a Resource in Clinical Trials. Mathematical Biosciences & Engineering, 2005, 2 (3) : 421-436. doi: 10.3934/mbe.2005.2.421
[18]

Adélia Sequeira, Rafael F. Santos, Tomáš Bodnár. Blood coagulation dynamics: mathematical modeling and stability results. Mathematical Biosciences & Engineering, 2011, 8 (2) : 425-443. doi: 10.3934/mbe.2011.8.425
[19]

Victor Fabian Morales-Delgado, José Francisco Gómez-Aguilar, Marco Antonio Taneco-Hernández. Mathematical modeling approach to the fractional Bergman's model. Discrete & Continuous Dynamical Systems - S, 2018, 0 (0) : 805-821. doi: 10.3934/dcdss.2020046
[20]

Yueping Dong, Rinko Miyazaki, Yasuhiro Takeuchi. Mathematical modeling on helper T cells in a tumor immune system. Discrete & Continuous Dynamical Systems - B, 2014, 19 (1) : 55-72. doi: 10.3934/dcdsb.2014.19.55

2018 Impact Factor: 1.008

Tools

Metrics

  • PDF downloads (6)
  • HTML views (0)
  • Cited by (3)

Other articles
by authors

[Back to Top]

Copyright © 2019 American Institute of Mathematical Sciences