American Institute of Mathematical Sciences

Advanced
September  2009, 12(2): 305-321. doi: 10.3934/dcdsb.2009.12.305

Mathematical modelling of internal HIV dynamics

Nirav Dalal 1, , David Greenhalgh 1, and  Xuerong Mao 1,

1. 

Department of Statistics and Modelling Science, Livingstone Tower, 26 Richmond Street, Glasgow G1 1XH, United Kingdom, United Kingdom

Received  October 2008 Revised  April 2009 Published  July 2009

We study a mathematical model for the viral dynamics of HIV in an infected individual in the presence of HAART. The paper starts with a literature review and then formulates the basic mathematical model. An expression for $R_0$, the basic reproduction number of the virus under steady state application of HAART, is derived followed by an equilibrium and stability analysis. There is always a disease-free equilibrium (DFE) which is globally asymptotically stable for $R_0 < 1$. Deterministic simulations with realistic parameter values give additional insight into the model behaviour.
Keywords: equilibrium and stability analysis, HAART, differential equations, simulation., stochastic model, deterministic model, AIDS, probability of extinction, HIV, $R_0$.
Mathematics Subject Classification: Primary: 92B05, 92D25; Secondary: 34D23, 60J85, 92D3.
Citation: Nirav Dalal, David Greenhalgh, Xuerong Mao. Mathematical modelling of internal HIV dynamics. Discrete & Continuous Dynamical Systems - B, 2009, 12 (2) : 305-321. doi: 10.3934/dcdsb.2009.12.305
[1]

Nicolas Bacaër, Xamxinur Abdurahman, Jianli Ye, Pierre Auger. On the basic reproduction number $R_0$ in sexual activity models for HIV/AIDS epidemics: Example from Yunnan, China. Mathematical Biosciences & Engineering, 2007, 4 (4) : 595-607. doi: 10.3934/mbe.2007.4.595
[2]

Miaomiao Gao, Daqing Jiang, Tasawar Hayat, Ahmed Alsaedi, Bashir Ahmad. Dynamics of a stochastic HIV/AIDS model with treatment under regime switching. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021181
[3]

Benjamin H. Singer, Denise E. Kirschner. Influence of backward bifurcation on interpretation of $R_0$ in a model of epidemic tuberculosis with reinfection. Mathematical Biosciences & Engineering, 2004, 1 (1) : 81-93. doi: 10.3934/mbe.2004.1.81
[4]

Toshikazu Kuniya, Mimmo Iannelli. $R_0$ and the global behavior of an age-structured SIS epidemic model with periodicity and vertical transmission. Mathematical Biosciences & Engineering, 2014, 11 (4) : 929-945. doi: 10.3934/mbe.2014.11.929
[5]

Cameron J. Browne, Sergei S. Pilyugin. Minimizing $\mathcal R_0$ for in-host virus model with periodic combination antiviral therapy. Discrete & Continuous Dynamical Systems - B, 2016, 21 (10) : 3315-3330. doi: 10.3934/dcdsb.2016099
[6]

Rachid Ouifki, Gareth Witten. A model of HIV-1 infection with HAART therapy and intracellular delays. Discrete & Continuous Dynamical Systems - B, 2007, 8 (1) : 229-240. doi: 10.3934/dcdsb.2007.8.229
[7]

Hongyong Zhao, Peng Wu, Shigui Ruan. Dynamic analysis and optimal control of a three-age-class HIV/AIDS epidemic model in China. Discrete & Continuous Dynamical Systems - B, 2020, 25 (9) : 3491-3521. doi: 10.3934/dcdsb.2020070
[8]

Praveen Kumar Gupta, Ajoy Dutta. Numerical solution with analysis of HIV/AIDS dynamics model with effect of fusion and cure rate. Numerical Algebra, Control & Optimization, 2019, 9 (4) : 393-399. doi: 10.3934/naco.2019038
[9]

C. Burgos, J.-C. Cortés, L. Shaikhet, R.-J. Villanueva. A delayed nonlinear stochastic model for cocaine consumption: Stability analysis and simulation using real data. Discrete & Continuous Dynamical Systems - S, 2021, 14 (4) : 1233-1244. doi: 10.3934/dcdss.2020356
[10]

Ténan Yeo. Stochastic and deterministic SIS patch model. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2021012
[11]

Cristiana J. Silva, Delfim F. M. Torres. A TB-HIV/AIDS coinfection model and optimal control treatment. Discrete & Continuous Dynamical Systems, 2015, 35 (9) : 4639-4663. doi: 10.3934/dcds.2015.35.4639
[12]

Hisashi Inaba. The Malthusian parameter and $R_0$ for heterogeneous populations in periodic environments. Mathematical Biosciences & Engineering, 2012, 9 (2) : 313-346. doi: 10.3934/mbe.2012.9.313
[13]

Christine K. Yang, Fred Brauer. Calculation of $R_0$ for age-of-infection models. Mathematical Biosciences & Engineering, 2008, 5 (3) : 585-599. doi: 10.3934/mbe.2008.5.585
[14]

Songbai Guo, Wanbiao Ma. Global behavior of delay differential equations model of HIV infection with apoptosis. Discrete & Continuous Dynamical Systems - B, 2016, 21 (1) : 103-119. doi: 10.3934/dcdsb.2016.21.103
[15]

M. Hadjiandreou, Raul Conejeros, Vassilis S. Vassiliadis. Towards a long-term model construction for the dynamic simulation of HIV infection. Mathematical Biosciences & Engineering, 2007, 4 (3) : 489-504. doi: 10.3934/mbe.2007.4.489
[16]

Gigi Thomas, Edward M. Lungu. A two-sex model for the influence of heavy alcohol consumption on the spread of HIV/AIDS. Mathematical Biosciences & Engineering, 2010, 7 (4) : 871-904. doi: 10.3934/mbe.2010.7.871
[17]

Yayun Zheng, Xu Sun. Governing equations for Probability densities of stochastic differential equations with discrete time delays. Discrete & Continuous Dynamical Systems - B, 2017, 22 (9) : 3615-3628. doi: 10.3934/dcdsb.2017182
[18]

Claude-Michel Brauner, Xinyue Fan, Luca Lorenzi. Two-dimensional stability analysis in a HIV model with quadratic logistic growth term. Communications on Pure & Applied Analysis, 2013, 12 (5) : 1813-1844. doi: 10.3934/cpaa.2013.12.1813
[19]

A. M. Elaiw, N. H. AlShamrani, A. Abdel-Aty, H. Dutta. Stability analysis of a general HIV dynamics model with multi-stages of infected cells and two routes of infection. Discrete & Continuous Dynamical Systems - S, 2021, 14 (10) : 3541-3556. doi: 10.3934/dcdss.2020441
[20]

Ana I. Muñoz, José Ignacio Tello. Mathematical analysis and numerical simulation of a model of morphogenesis. Mathematical Biosciences & Engineering, 2011, 8 (4) : 1035-1059. doi: 10.3934/mbe.2011.8.1035

2020 Impact Factor: 1.327

Tools

Metrics

  • PDF downloads (54)
  • HTML views (0)
  • Cited by (6)

Other articles
by authors

[Back to Top]

Copyright © 2021 American Institute of Mathematical Sciences