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Robust closed-loop control of plasma glycemia: A discrete-delay model approach

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  • The paper investigates the problem of tracking a desired plasma glucose evolution by means of intra-venous insulin administration. A model-based approach is followed. A recent model of the glucose/insulin regulatory system which consists of discrete-delay nonlinear differential equations is used. A disturbance is added to the insulin kinetics in order to model uncertainties concerning both the insulin delivery rate and the mechanism actuating the insulin pump. A feedback control law which yields input-to-state stability of the closed loop error system with respect to the disturbance is provided. Such control law depends on the glucose and insulin measurements at the present and at a delayed time. In silico simulations validate the theoretical results.
    Mathematics Subject Classification: Primary: 58F15, 58F17; Secondary: 53C35.


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