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June  2013, 18(4): 1053-1076. doi: 10.3934/dcdsb.2013.18.1053

B cell chronic lymphocytic leukemia - A model with immune response

Seema Nanda 1, , Lisette dePillis 2, and  Ami Radunskaya 3,

1. 

Tata Institute of Fundamental Research, Centre for Applicable Mathematics, Bangalore 560065, India
2. 

Department of Mathematics, Harvey Mudd College, Claremont, CA 91711
3. 

Department of Mathematics, Pomona College, Claremont, CA, 91711, United States

Received  August 2012 Revised  October 2012 Published  February 2013

B cell chronic lymphocytic leukemia (B-CLL) is known to have substantial clinical heterogeneity. There is no cure, but treatments allow for disease management. However, the wide range of clinical courses experienced by B-CLL patients makes prognosis and hence treatment a significant challenge. In an attempt to study disease progression across different patients via a unified yet flexible approach, we present a mathematical model of B-CLL with immune response, that can capture both rapid and slow disease progression. This model includes four different cell populations in the peripheral blood of humans: B-CLL cells, NK cells, cytotoxic T cells and helper T cells. We analyze existing data in the medical literature, determine ranges of values for parameters of the model, and compare our model outcomes to clinical patient data. The goal of this work is to provide a tool that may shed light on factors affecting the course of disease progression in patients. This modeling tool can serve as a foundation upon which future treatments can be based.
Keywords: NK cell, chronic lymphocytic leukemia, mathematical model, T cell., B-CLL.
Mathematics Subject Classification: Primary: 92C550, 92B05; Secondary: 37N25, 62H9.
Citation: Seema Nanda, Lisette dePillis, Ami Radunskaya. B cell chronic lymphocytic leukemia - A model with immune response. Discrete & Continuous Dynamical Systems - B, 2013, 18 (4) : 1053-1076. doi: 10.3934/dcdsb.2013.18.1053
References:
[1]

M. J. Keating, N. Chiorazzi, B. Messmer, R. N. Damle, S. L. Allen, K. R. Rai, et al., Biology and treatment of chronic lymphocytic leukemia, American Society of Hematology, [Review], 153 (2003), 153-175. Google Scholar

[2]

N. Chiorazzi, K. R. Rai and M. Ferrarini, Mechanisms of disease: Chronic lymphocytic leukemia, The New England Journal of Medicine, 352 (2005), 804-815, [http://www.nejm.org]. Google Scholar

[3]

F. Caligaris-Cappio and R. D. Favera (Eds), "Chronic Lymphocytic Leukemia," No. 294 in Current Topics in Microbiology and Immunology, Springer, 1 edition 2005. Google Scholar

[4]

C. Imai, S. Iwamoto and D. Campana, Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells, Blood, 106 (2005), 376-383. Google Scholar

[5]

S. Y. Zimmermann, R. Esser, E. Rohrbach, T. Klingebiel and U. Koehl, A novel four-colour flow cytometric assay to determine natural killer cell or T-cell-mediated cellular cytotoxicity against leukaemic cells in peripheral or bone marrow specimens containing greater than 20 Journal of Immunological Methods, 296 (2005), 63-76. Google Scholar

[6]

H. Guven, M. Gilljam, B. Chambers, H. Ljunggren, B. Christensson, E. Kimby, et al., Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL), a potential source for cellular immunotherapy, Leukemia, 17 (2003), 1973-1980. Google Scholar

[7]

R. J. Prestwich, F. Errington, P. Hatfieldy, A. E. Merrick, E. J. Ilett, P. J. Selby, et al., The immune system - Is it relevant to cancer development, progression and treatment? Clinical Oncology, 20 (2008), 101-112. Google Scholar

[8]

E. Gitelson, C. Hammond, J. Mena, M. Lorenzo, R. Buckstein, N. L. Berinstein, et al., Chronic lymphocytic leukemia-reactive T cells during disease progression and after autologous tumor cell vaccines, Clinical Cancer Research, 9 (2003), 1656-1665. Google Scholar

[9]

M. C. Mackey, C. Ou, L. Pujo-Menjouet and J. Wu, Periodic oscillations of blood cell populations in chronic myelogenous leukemia, SIAM J. Math. Anal., 38 (2006), 166-187. doi: 10.1137/04061578X.  Google Scholar

[10]

C. Colijn and M. C. Mackey, A mathematical model of hematopoiesis - I. Periodic chronic myelogenous leukemia, Journal of Theoretical Biology, 237 (2005), 117-146. doi: 10.1016/j.jtbi.2005.03.033.  Google Scholar

[11]

H. Moore and N. K. Li, A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction, Journal of Theoretical Biology, 227 (2004), 513-523. doi: 10.1016/j.jtbi.2003.11.024.  Google Scholar

[12]

C. Haurie, D. C. Dale and M. C. Mackey, Cyclical neutropenia and other periodic hematological disorders: A review of mechanisms and mathematical models, Blood, 92 (1998), 2629-2640. Google Scholar

[13]

B. Vitale, M. Martinis, M. Antica, B. Kusic, S. Rabatic, A. Gagro, et al., Prolegomenon for chronic lymphocytic leukaemia, Scandinavian Journal of Immunology, 58 (2003), 588-600. Google Scholar

[14]

M. Martinis, B. Vitale, V. Zlatic, B. Dobrosevic and K. Dodig, Mathematical model of B-cell chronic lymphocytic leukemia (CLL), Periodicum Biologorum, 107 (2005), 445-450. Google Scholar

[15]

S. I. Niculescu, P. S. Kim, K. Gu, P. P. Lee and D. Levy, Stability crossing boundaries of delaty sustems modeling immune dynamics in leukemia, Discrete and Continuous Dynamical Systems Series B, 13 (2010), 129-156. doi: 10.3934/dcdsb.2010.13.129.  Google Scholar

[16]

B. T. Messmer, D. Messmer, S. L. Allen, J. E. Kolitz, P. Kudalkar, D. Cesar, et al., In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells, The Journal of Clinical Investigation, 115 (2005), 755-764. Google Scholar

[17]

H. Mellstedt and A. Choudhur, T and B cells in in B-chronic lymphocytic leukaemia: Faust, mephistopheles and the pact with the devil, Cancer Immunology, 55 (2006), 210-220. Google Scholar

[18]

A. L. Shaffer III, R. M. Young and L. M. Staudt, Pathogenesis of human B cell lymphomas, Annual Review of Immunology, 30 (2012), 565-610. Google Scholar

[19]

L. G. dePillis, A. E. Radunskaya and C. L. Wiseman, A validated mathematical model of cell-mediated immune response to tumor growth, Cancer Research, 65 (2005), 7950-7958. Google Scholar

[20]

C. A. Janeway, P. Travers, M. Walport andM. J. Shlomchik, "Immunobiology," Garland Science, 6th edition 2005. Google Scholar

[21]

V. A. Kuznetsov, I. A. Makalkin, M. A. Taylor and A. S. Perelson, Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis, Bulletin of Mathematical Biology, 56 (1994), 295-321. Google Scholar

[22]

S. M. Blower and H. Dowlatabadi, Sensitivity and uncertainty analysis of complex models of disease transmission: An HIV model, as an example, International Statistical Review, 62 (1994), 229-243. Google Scholar

[23]

M. Hellerstein, M. Hanley, D. Cesar, S. Siler, C. Papageorgopoulos, E. Wieder, et al., Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans, Nature Medicine, 5 (1999), 83-89. Google Scholar

[24]

A. M. Jamieson, P. Isnard, J. R. Dorfman, M. C. Coles and D. H. Raulet, Turnover and proliferation of NK cells in steady state and lymphopenic conditions, The Journal of Immunology, 172 (2004), 864-870. Google Scholar

[25]

R. J. DeBoer, H. Mohri, D. D. Ho and A. S. Perelson, Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques, The Journal of Immunology, 170 (2003), 2479-2487. Google Scholar

[26]

A. K. Abbas, A. H. Lichtman and S. Pillai, "Cellular and Molecular Immunology," Saunders, 7 edition 2007. Google Scholar

[27]

A. Shimoni, H. Marcus, A. Canaan, D. Ergas, M. David, A. Berrebi, et al., A model for human B-chronic lymphocytic leukemia in human/mouse radiation chimera: Evidence for tumor-mediated suppression of antibody production in low-stage disease, Blood, 89 (1997), 2210-2218. Google Scholar

[28]

Y. Jiang, H. Shang, Z. Zhang, Y. Diao, D. Dai, W. Geng, et al., Alterations of natural killer cell and T-lymphocyte counts in adults infected with human immunodeficiency virus through blood and plasma sold in the past in China and in whom infection has progressed slowly over a long period, Clinical and Diagnostic Laboratory Immunology, 12 (2005), 1275-1279. Google Scholar

[29]

E. Kimby, H. Mellstedt, B. Nilsson, M. Björkholm and G. Holm, Differences in blood T and NK cell populations between chronic lymphocytic leukemia of B cell type (B-CLL) and monoclonal B-Lymphocytes of Undetermined Significance (B-MLUS), Leukemia, 3 (1989), 501-504. Google Scholar

[30]

M. Hernberg, T. Muhonen, J. P. Turunen, M .Hahka-Kemppinen and S. Pyrhonen, The CD4+/CD8+ ratio as a prognostic factor in patients with metastatic melanoma receiving chemoimmunotherapy, Journal Of Clinical Oncology, 14 (1996), 1698-1696. Google Scholar

[31]

I. Tinhofer, I. Marschitz, M. Kos, T. Henn, A. Egle, A. Villunger and R. Greil, Differential sensitivity of CD41 and CD81 T lymphocytes to the killing efficacy of fas (Apo-1/CD95) Ligand1 tumor cells in B chronic lymphocytic leukemia, Blood, 91 (1998), 4273-4281. Google Scholar

[32]

G. B. West, J. H. Brown and B. J. Enquist, A general model for the origin of allometric scaling laws in biology, Science, 276 (1997), 122-126. Google Scholar

[33]

A. McClean and C. Michie, In vivo estimates of division and death rates of general human T lymphocytes, Proc. Natl. Acad. Sci. USA, 92 (1995), 3707-3711. Google Scholar

show all references

References:
[1]

M. J. Keating, N. Chiorazzi, B. Messmer, R. N. Damle, S. L. Allen, K. R. Rai, et al., Biology and treatment of chronic lymphocytic leukemia, American Society of Hematology, [Review], 153 (2003), 153-175. Google Scholar

[2]

N. Chiorazzi, K. R. Rai and M. Ferrarini, Mechanisms of disease: Chronic lymphocytic leukemia, The New England Journal of Medicine, 352 (2005), 804-815, [http://www.nejm.org]. Google Scholar

[3]

F. Caligaris-Cappio and R. D. Favera (Eds), "Chronic Lymphocytic Leukemia," No. 294 in Current Topics in Microbiology and Immunology, Springer, 1 edition 2005. Google Scholar

[4]

C. Imai, S. Iwamoto and D. Campana, Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells, Blood, 106 (2005), 376-383. Google Scholar

[5]

S. Y. Zimmermann, R. Esser, E. Rohrbach, T. Klingebiel and U. Koehl, A novel four-colour flow cytometric assay to determine natural killer cell or T-cell-mediated cellular cytotoxicity against leukaemic cells in peripheral or bone marrow specimens containing greater than 20 Journal of Immunological Methods, 296 (2005), 63-76. Google Scholar

[6]

H. Guven, M. Gilljam, B. Chambers, H. Ljunggren, B. Christensson, E. Kimby, et al., Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL), a potential source for cellular immunotherapy, Leukemia, 17 (2003), 1973-1980. Google Scholar

[7]

R. J. Prestwich, F. Errington, P. Hatfieldy, A. E. Merrick, E. J. Ilett, P. J. Selby, et al., The immune system - Is it relevant to cancer development, progression and treatment? Clinical Oncology, 20 (2008), 101-112. Google Scholar

[8]

E. Gitelson, C. Hammond, J. Mena, M. Lorenzo, R. Buckstein, N. L. Berinstein, et al., Chronic lymphocytic leukemia-reactive T cells during disease progression and after autologous tumor cell vaccines, Clinical Cancer Research, 9 (2003), 1656-1665. Google Scholar

[9]

M. C. Mackey, C. Ou, L. Pujo-Menjouet and J. Wu, Periodic oscillations of blood cell populations in chronic myelogenous leukemia, SIAM J. Math. Anal., 38 (2006), 166-187. doi: 10.1137/04061578X.  Google Scholar

[10]

C. Colijn and M. C. Mackey, A mathematical model of hematopoiesis - I. Periodic chronic myelogenous leukemia, Journal of Theoretical Biology, 237 (2005), 117-146. doi: 10.1016/j.jtbi.2005.03.033.  Google Scholar

[11]

H. Moore and N. K. Li, A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction, Journal of Theoretical Biology, 227 (2004), 513-523. doi: 10.1016/j.jtbi.2003.11.024.  Google Scholar

[12]

C. Haurie, D. C. Dale and M. C. Mackey, Cyclical neutropenia and other periodic hematological disorders: A review of mechanisms and mathematical models, Blood, 92 (1998), 2629-2640. Google Scholar

[13]

B. Vitale, M. Martinis, M. Antica, B. Kusic, S. Rabatic, A. Gagro, et al., Prolegomenon for chronic lymphocytic leukaemia, Scandinavian Journal of Immunology, 58 (2003), 588-600. Google Scholar

[14]

M. Martinis, B. Vitale, V. Zlatic, B. Dobrosevic and K. Dodig, Mathematical model of B-cell chronic lymphocytic leukemia (CLL), Periodicum Biologorum, 107 (2005), 445-450. Google Scholar

[15]

S. I. Niculescu, P. S. Kim, K. Gu, P. P. Lee and D. Levy, Stability crossing boundaries of delaty sustems modeling immune dynamics in leukemia, Discrete and Continuous Dynamical Systems Series B, 13 (2010), 129-156. doi: 10.3934/dcdsb.2010.13.129.  Google Scholar

[16]

B. T. Messmer, D. Messmer, S. L. Allen, J. E. Kolitz, P. Kudalkar, D. Cesar, et al., In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells, The Journal of Clinical Investigation, 115 (2005), 755-764. Google Scholar

[17]

H. Mellstedt and A. Choudhur, T and B cells in in B-chronic lymphocytic leukaemia: Faust, mephistopheles and the pact with the devil, Cancer Immunology, 55 (2006), 210-220. Google Scholar

[18]

A. L. Shaffer III, R. M. Young and L. M. Staudt, Pathogenesis of human B cell lymphomas, Annual Review of Immunology, 30 (2012), 565-610. Google Scholar

[19]

L. G. dePillis, A. E. Radunskaya and C. L. Wiseman, A validated mathematical model of cell-mediated immune response to tumor growth, Cancer Research, 65 (2005), 7950-7958. Google Scholar

[20]

C. A. Janeway, P. Travers, M. Walport andM. J. Shlomchik, "Immunobiology," Garland Science, 6th edition 2005. Google Scholar

[21]

V. A. Kuznetsov, I. A. Makalkin, M. A. Taylor and A. S. Perelson, Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis, Bulletin of Mathematical Biology, 56 (1994), 295-321. Google Scholar

[22]

S. M. Blower and H. Dowlatabadi, Sensitivity and uncertainty analysis of complex models of disease transmission: An HIV model, as an example, International Statistical Review, 62 (1994), 229-243. Google Scholar

[23]

M. Hellerstein, M. Hanley, D. Cesar, S. Siler, C. Papageorgopoulos, E. Wieder, et al., Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans, Nature Medicine, 5 (1999), 83-89. Google Scholar

[24]

A. M. Jamieson, P. Isnard, J. R. Dorfman, M. C. Coles and D. H. Raulet, Turnover and proliferation of NK cells in steady state and lymphopenic conditions, The Journal of Immunology, 172 (2004), 864-870. Google Scholar

[25]

R. J. DeBoer, H. Mohri, D. D. Ho and A. S. Perelson, Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques, The Journal of Immunology, 170 (2003), 2479-2487. Google Scholar

[26]

A. K. Abbas, A. H. Lichtman and S. Pillai, "Cellular and Molecular Immunology," Saunders, 7 edition 2007. Google Scholar

[27]

A. Shimoni, H. Marcus, A. Canaan, D. Ergas, M. David, A. Berrebi, et al., A model for human B-chronic lymphocytic leukemia in human/mouse radiation chimera: Evidence for tumor-mediated suppression of antibody production in low-stage disease, Blood, 89 (1997), 2210-2218. Google Scholar

[28]

Y. Jiang, H. Shang, Z. Zhang, Y. Diao, D. Dai, W. Geng, et al., Alterations of natural killer cell and T-lymphocyte counts in adults infected with human immunodeficiency virus through blood and plasma sold in the past in China and in whom infection has progressed slowly over a long period, Clinical and Diagnostic Laboratory Immunology, 12 (2005), 1275-1279. Google Scholar

[29]

E. Kimby, H. Mellstedt, B. Nilsson, M. Björkholm and G. Holm, Differences in blood T and NK cell populations between chronic lymphocytic leukemia of B cell type (B-CLL) and monoclonal B-Lymphocytes of Undetermined Significance (B-MLUS), Leukemia, 3 (1989), 501-504. Google Scholar

[30]

M. Hernberg, T. Muhonen, J. P. Turunen, M .Hahka-Kemppinen and S. Pyrhonen, The CD4+/CD8+ ratio as a prognostic factor in patients with metastatic melanoma receiving chemoimmunotherapy, Journal Of Clinical Oncology, 14 (1996), 1698-1696. Google Scholar

[31]

I. Tinhofer, I. Marschitz, M. Kos, T. Henn, A. Egle, A. Villunger and R. Greil, Differential sensitivity of CD41 and CD81 T lymphocytes to the killing efficacy of fas (Apo-1/CD95) Ligand1 tumor cells in B chronic lymphocytic leukemia, Blood, 91 (1998), 4273-4281. Google Scholar

[32]

G. B. West, J. H. Brown and B. J. Enquist, A general model for the origin of allometric scaling laws in biology, Science, 276 (1997), 122-126. Google Scholar

[33]

A. McClean and C. Michie, In vivo estimates of division and death rates of general human T lymphocytes, Proc. Natl. Acad. Sci. USA, 92 (1995), 3707-3711. Google Scholar

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