# American Institute of Mathematical Sciences

• Previous Article
A kinetic energy reduction technique and characterizations of the ground states of spin-1 Bose-Einstein condensates
• DCDS-B Home
• This Issue
• Next Article
Complete classification of global dynamics of a virus model with immune responses
June  2014, 19(4): 1105-1118. doi: 10.3934/dcdsb.2014.19.1105

## Global stability of a multi-group SIS epidemic model for population migration

 1 Graduate School of System Informatics, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan 2 Department of Mathematics, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, 169-8555

Received  December 2012 Revised  October 2013 Published  April 2014

In this paper, using an approach of Lyapunov functional, we establish the complete global stability of a multi-group SIS epidemic model in which the effect of population migration among different regions is considered. We prove the global asymptotic stability of the disease-free equilibrium of the model for $R_0\leq 1$, and that of an endemic equilibrium for $R_0>1$. Here $R_0$ denotes the well-known basic reproduction number defined by the spectral radius of an irreducible nonnegative matrix called the next generation matrix. We emphasize that the graph-theoretic approach, which is typically used for multi-group epidemic models, is not needed in our proof.
Citation: Toshikazu Kuniya, Yoshiaki Muroya. Global stability of a multi-group SIS epidemic model for population migration. Discrete & Continuous Dynamical Systems - B, 2014, 19 (4) : 1105-1118. doi: 10.3934/dcdsb.2014.19.1105
##### References:
 [1] J. Arino, Diseases in metapopulations,, in Modeling and Dynamics of Infectious Diseases (eds. Z. Ma, (2009), 65.   Google Scholar [2] A. Berman and R. J. Plemmons, Nonnegative Matrices in the Mathematical Sciences,, Academic Press, (1979).   Google Scholar [3] N. P. Bhatia and G. P. Szegö, Dynamical Systems: Stability Theory and Applications,, Springer, (1967).   Google Scholar [4] S. N. Busenberg, M. Iannelli and H. R. Thieme, Global behavior of an age-structured epidemic model,, SIAM J. Math. Anal., 22 (1991), 1065.  doi: 10.1137/0522069.  Google Scholar [5] H. Chen and J. Sun, Global stability of delay multigroup epidemic models with group mixing nonlinear incidence rates,, Appl. Math. Comput., 218 (2011), 4391.  doi: 10.1016/j.amc.2011.10.015.  Google Scholar [6] O. Diekmann, J. A. P. Heesterbeek and J. A. J. Metz, On the definition and the computation of the basic reproduction ratio $R_0$ in models for infectious diseases in heterogeneous populations,, J. Math. Biol., 28 (1990), 365.  doi: 10.1007/BF00178324.  Google Scholar [7] O. Diekmann and J. A. P. Heesterbeek, Mathematical Epidemiology of Infectious Diseases,, Wiley, (2000).   Google Scholar [8] Z. Feng, W. Huang and C. Castillo-Chavez, Global behavior of a multi-group SIS epidemic model with age structure,, J. Diff. Equat., 218 (2005), 292.  doi: 10.1016/j.jde.2004.10.009.  Google Scholar [9] H. I. Freedman, M. X. Tang and S. G. Ruan, Uniform persistence and flows near a closed positively invariant set,, J. Dynam. Diff. Equat., 6 (1994), 583.  doi: 10.1007/BF02218848.  Google Scholar [10] H. Guo, M. Y. Li and Z. Shuai, Global stability of the endemic equilibrium of multigroup SIR epidemic models,, Canadian Appl. Math. Quart., 14 (2006), 259.   Google Scholar [11] H. Guo, M. Y. Li and Z. Shuai, A graph-theoretic approach to the method of global Lyapunov functions,, Proc. Amer. Math. Soc., 136 (2008), 2793.  doi: 10.1090/S0002-9939-08-09341-6.  Google Scholar [12] G. Huang and Y. Takeuchi, Global analysis on delay epidemiological dynamic models with nonlinear incidence,, J. Math. Biol., 63 (2011), 125.  doi: 10.1007/s00285-010-0368-2.  Google Scholar [13] T. Kuniya, Global stability analysis with a discretization approach for an age-structured multigroup SIR epidemic model,, Nonlinear Analysis RWA., 12 (2011), 2640.  doi: 10.1016/j.nonrwa.2011.03.011.  Google Scholar [14] A. Lajmanovich and J. A. Yorke, A deterministic model for gonorrhea in a nonhomogeneous population,, Math. Biosci., 28 (1976), 221.  doi: 10.1016/0025-5564(76)90125-5.  Google Scholar [15] J. P. LaSalle, The Stability of Dynamical Systems,, SIAM, (1976).   Google Scholar [16] M. Y. Li, J. R. Graef, L. Wang and J. Karsai, Global dynamics of a SEIR model with varying total population size,, Math. Biosci., 160 (1999), 191.  doi: 10.1016/S0025-5564(99)00030-9.  Google Scholar [17] M. Y. Li and Z. Shuai, Global-stability problem for coupled systems of differential equations on networks,, J. Diff. Equat., 284 (2010), 1.  doi: 10.1016/j.jde.2009.09.003.  Google Scholar [18] M. Y. Li, Z. Shuai and C. Wang, Global stability of multi-group epidemic models with distributed delays,, J. Math. Anal. Appl., 361 (2010), 38.  doi: 10.1016/j.jmaa.2009.09.017.  Google Scholar [19] J. Liu and Y. Zhou, Global stability of an SIRS epidemic model with transport-related infection,, Chaos Solitons and Fractals, 40 (2009), 145.  doi: 10.1016/j.chaos.2007.07.047.  Google Scholar [20] X. Liu and Y. Takeuchi, Spread of disease with transport-related infection and entry screening,, J. Theoret. Biol., 242 (2006), 517.  doi: 10.1016/j.jtbi.2006.03.018.  Google Scholar [21] C. C. McCluskey, Complete global stability for an SIR epidemic model with delay (distributed or discrete),, Nonlinear Analysis RWA., 11 (2010), 55.  doi: 10.1016/j.nonrwa.2008.10.014.  Google Scholar [22] K. Mischaikow, H. L. Smith and H. R. Thieme, Asymptotically autonomous semiflows: chain recurrence and Lyapunov functions,, Trans. Amer. Math. Soc., 347 (1995), 1669.  doi: 10.1090/S0002-9947-1995-1290727-7.  Google Scholar [23] Y. Muroya, A. Bellen, Y. Enatsu and Y. Nakata, Global stability for a discrete epidemic model for disease with immunity and latency spreading in a heterogeneous host population,, Nonlinear Analysis RWA., 13 (2012), 258.  doi: 10.1016/j.nonrwa.2011.07.031.  Google Scholar [24] Y. Muroya, Y. Enatsu and T. Kuniya, Global stability for a multi-group SIRS epidemic model with varying population sizes,, Nonlinear Analysis RWA., 14 (2013), 1693.  doi: 10.1016/j.nonrwa.2012.11.005.  Google Scholar [25] Y. Muroya, Y. Enatsu and T. Kuniya, Global stability of extended multi-group sir epidemic models with patches through migration and cross patch infection,, Acta Mathematica Scientia, 33 (2013), 341.  doi: 10.1016/S0252-9602(13)60003-X.  Google Scholar [26] Y. Nakata, On the global stability of a delayed epidemic model with transport-related infection,, Nonlinear Analysis RWA., 12 (2011), 3028.  doi: 10.1016/j.nonrwa.2011.05.004.  Google Scholar [27] H. L. Smith and P. Waltman, The Theory of the Chemostat: Dynamics of Microbial Competition,, Cambridge University Press, (1995).  doi: 10.1017/CBO9780511530043.  Google Scholar [28] H. Shu, D. Fan and J. Wei, Global stability of multi-group SEIR epidemic models with distributed delays and nonlinear transmission,, Nonlinear Analysis RWA., 13 (2012), 1581.  doi: 10.1016/j.nonrwa.2011.11.016.  Google Scholar [29] R. Sun, Global stability of the endemic equilibrium of multigroup SIR models with nonlinear incidence,, Comput. Math. Appl., 60 (2010), 2286.  doi: 10.1016/j.camwa.2010.08.020.  Google Scholar [30] H. R. Thieme, Convergence results and a Poincaré-Bendixson trichotomy for asymptotically autonomous differential equations,, J. Math. Biol., 30 (1992), 755.  doi: 10.1007/BF00173267.  Google Scholar [31] H. R. Thieme, Spectral bound and reproduction number for infinite-dimensional population structure and time heterogeneity,, SIAM J. Appl. Math., 70 (2009), 188.  doi: 10.1137/080732870.  Google Scholar [32] P. van den Driessche and J. Watmough, Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission,, Math. Biosci., 180 (2002), 29.  doi: 10.1016/S0025-5564(02)00108-6.  Google Scholar [33] R. S. Varga, Matrix Iterative Analysis,, Prentice-Hall, (1962).   Google Scholar [34] C. Vargas-De-León, On the global stability of SIS, SIR and SIRS epidemic models with standard incidence,, Chaos Solitons and Fractals, 44 (2011), 1106.  doi: 10.1016/j.chaos.2011.09.002.  Google Scholar [35] W. Wang and X. Zhao, An epidemic model in a patchy environment,, Math. Biosci., 190 (2004), 97.  doi: 10.1016/j.mbs.2002.11.001.  Google Scholar [36] L. Wang and G. Z. Dai, Global stability of virus spreading in complex heterogeneous networks,, SIAM J. Appl. Math., 68 (2008), 1495.  doi: 10.1137/070694582.  Google Scholar [37] Z. Yuan and L. Wang, Global stability of epidemiological models with group mixing and nonlinear incidence rates,, Nonlinear Analysis RWA., 11 (2010), 995.  doi: 10.1016/j.nonrwa.2009.01.040.  Google Scholar [38] Z. Yuan and X. Zou, Global threshold property in an epidemic models for disease with latency spreading in a heterogeneous host population,, Nonlinear Analysis RWA., 11 (2010), 3479.  doi: 10.1016/j.nonrwa.2009.12.008.  Google Scholar

show all references

##### References:
 [1] J. Arino, Diseases in metapopulations,, in Modeling and Dynamics of Infectious Diseases (eds. Z. Ma, (2009), 65.   Google Scholar [2] A. Berman and R. J. Plemmons, Nonnegative Matrices in the Mathematical Sciences,, Academic Press, (1979).   Google Scholar [3] N. P. Bhatia and G. P. Szegö, Dynamical Systems: Stability Theory and Applications,, Springer, (1967).   Google Scholar [4] S. N. Busenberg, M. Iannelli and H. R. Thieme, Global behavior of an age-structured epidemic model,, SIAM J. Math. Anal., 22 (1991), 1065.  doi: 10.1137/0522069.  Google Scholar [5] H. Chen and J. Sun, Global stability of delay multigroup epidemic models with group mixing nonlinear incidence rates,, Appl. Math. Comput., 218 (2011), 4391.  doi: 10.1016/j.amc.2011.10.015.  Google Scholar [6] O. Diekmann, J. A. P. Heesterbeek and J. A. J. Metz, On the definition and the computation of the basic reproduction ratio $R_0$ in models for infectious diseases in heterogeneous populations,, J. Math. Biol., 28 (1990), 365.  doi: 10.1007/BF00178324.  Google Scholar [7] O. Diekmann and J. A. P. Heesterbeek, Mathematical Epidemiology of Infectious Diseases,, Wiley, (2000).   Google Scholar [8] Z. Feng, W. Huang and C. Castillo-Chavez, Global behavior of a multi-group SIS epidemic model with age structure,, J. Diff. Equat., 218 (2005), 292.  doi: 10.1016/j.jde.2004.10.009.  Google Scholar [9] H. I. Freedman, M. X. Tang and S. G. Ruan, Uniform persistence and flows near a closed positively invariant set,, J. Dynam. Diff. Equat., 6 (1994), 583.  doi: 10.1007/BF02218848.  Google Scholar [10] H. Guo, M. Y. Li and Z. Shuai, Global stability of the endemic equilibrium of multigroup SIR epidemic models,, Canadian Appl. Math. Quart., 14 (2006), 259.   Google Scholar [11] H. Guo, M. Y. Li and Z. Shuai, A graph-theoretic approach to the method of global Lyapunov functions,, Proc. Amer. Math. Soc., 136 (2008), 2793.  doi: 10.1090/S0002-9939-08-09341-6.  Google Scholar [12] G. Huang and Y. Takeuchi, Global analysis on delay epidemiological dynamic models with nonlinear incidence,, J. Math. Biol., 63 (2011), 125.  doi: 10.1007/s00285-010-0368-2.  Google Scholar [13] T. Kuniya, Global stability analysis with a discretization approach for an age-structured multigroup SIR epidemic model,, Nonlinear Analysis RWA., 12 (2011), 2640.  doi: 10.1016/j.nonrwa.2011.03.011.  Google Scholar [14] A. Lajmanovich and J. A. Yorke, A deterministic model for gonorrhea in a nonhomogeneous population,, Math. Biosci., 28 (1976), 221.  doi: 10.1016/0025-5564(76)90125-5.  Google Scholar [15] J. P. LaSalle, The Stability of Dynamical Systems,, SIAM, (1976).   Google Scholar [16] M. Y. Li, J. R. Graef, L. Wang and J. Karsai, Global dynamics of a SEIR model with varying total population size,, Math. Biosci., 160 (1999), 191.  doi: 10.1016/S0025-5564(99)00030-9.  Google Scholar [17] M. Y. Li and Z. Shuai, Global-stability problem for coupled systems of differential equations on networks,, J. Diff. Equat., 284 (2010), 1.  doi: 10.1016/j.jde.2009.09.003.  Google Scholar [18] M. Y. Li, Z. Shuai and C. Wang, Global stability of multi-group epidemic models with distributed delays,, J. Math. Anal. Appl., 361 (2010), 38.  doi: 10.1016/j.jmaa.2009.09.017.  Google Scholar [19] J. Liu and Y. Zhou, Global stability of an SIRS epidemic model with transport-related infection,, Chaos Solitons and Fractals, 40 (2009), 145.  doi: 10.1016/j.chaos.2007.07.047.  Google Scholar [20] X. Liu and Y. Takeuchi, Spread of disease with transport-related infection and entry screening,, J. Theoret. Biol., 242 (2006), 517.  doi: 10.1016/j.jtbi.2006.03.018.  Google Scholar [21] C. C. McCluskey, Complete global stability for an SIR epidemic model with delay (distributed or discrete),, Nonlinear Analysis RWA., 11 (2010), 55.  doi: 10.1016/j.nonrwa.2008.10.014.  Google Scholar [22] K. Mischaikow, H. L. Smith and H. R. Thieme, Asymptotically autonomous semiflows: chain recurrence and Lyapunov functions,, Trans. Amer. Math. Soc., 347 (1995), 1669.  doi: 10.1090/S0002-9947-1995-1290727-7.  Google Scholar [23] Y. Muroya, A. Bellen, Y. Enatsu and Y. Nakata, Global stability for a discrete epidemic model for disease with immunity and latency spreading in a heterogeneous host population,, Nonlinear Analysis RWA., 13 (2012), 258.  doi: 10.1016/j.nonrwa.2011.07.031.  Google Scholar [24] Y. Muroya, Y. Enatsu and T. Kuniya, Global stability for a multi-group SIRS epidemic model with varying population sizes,, Nonlinear Analysis RWA., 14 (2013), 1693.  doi: 10.1016/j.nonrwa.2012.11.005.  Google Scholar [25] Y. Muroya, Y. Enatsu and T. Kuniya, Global stability of extended multi-group sir epidemic models with patches through migration and cross patch infection,, Acta Mathematica Scientia, 33 (2013), 341.  doi: 10.1016/S0252-9602(13)60003-X.  Google Scholar [26] Y. Nakata, On the global stability of a delayed epidemic model with transport-related infection,, Nonlinear Analysis RWA., 12 (2011), 3028.  doi: 10.1016/j.nonrwa.2011.05.004.  Google Scholar [27] H. L. Smith and P. Waltman, The Theory of the Chemostat: Dynamics of Microbial Competition,, Cambridge University Press, (1995).  doi: 10.1017/CBO9780511530043.  Google Scholar [28] H. Shu, D. Fan and J. Wei, Global stability of multi-group SEIR epidemic models with distributed delays and nonlinear transmission,, Nonlinear Analysis RWA., 13 (2012), 1581.  doi: 10.1016/j.nonrwa.2011.11.016.  Google Scholar [29] R. Sun, Global stability of the endemic equilibrium of multigroup SIR models with nonlinear incidence,, Comput. Math. Appl., 60 (2010), 2286.  doi: 10.1016/j.camwa.2010.08.020.  Google Scholar [30] H. R. Thieme, Convergence results and a Poincaré-Bendixson trichotomy for asymptotically autonomous differential equations,, J. Math. Biol., 30 (1992), 755.  doi: 10.1007/BF00173267.  Google Scholar [31] H. R. Thieme, Spectral bound and reproduction number for infinite-dimensional population structure and time heterogeneity,, SIAM J. Appl. Math., 70 (2009), 188.  doi: 10.1137/080732870.  Google Scholar [32] P. van den Driessche and J. Watmough, Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission,, Math. Biosci., 180 (2002), 29.  doi: 10.1016/S0025-5564(02)00108-6.  Google Scholar [33] R. S. Varga, Matrix Iterative Analysis,, Prentice-Hall, (1962).   Google Scholar [34] C. Vargas-De-León, On the global stability of SIS, SIR and SIRS epidemic models with standard incidence,, Chaos Solitons and Fractals, 44 (2011), 1106.  doi: 10.1016/j.chaos.2011.09.002.  Google Scholar [35] W. Wang and X. Zhao, An epidemic model in a patchy environment,, Math. Biosci., 190 (2004), 97.  doi: 10.1016/j.mbs.2002.11.001.  Google Scholar [36] L. Wang and G. Z. Dai, Global stability of virus spreading in complex heterogeneous networks,, SIAM J. Appl. Math., 68 (2008), 1495.  doi: 10.1137/070694582.  Google Scholar [37] Z. Yuan and L. Wang, Global stability of epidemiological models with group mixing and nonlinear incidence rates,, Nonlinear Analysis RWA., 11 (2010), 995.  doi: 10.1016/j.nonrwa.2009.01.040.  Google Scholar [38] Z. Yuan and X. Zou, Global threshold property in an epidemic models for disease with latency spreading in a heterogeneous host population,, Nonlinear Analysis RWA., 11 (2010), 3479.  doi: 10.1016/j.nonrwa.2009.12.008.  Google Scholar
 [1] Yoshiaki Muroya, Toshikazu Kuniya, Yoichi Enatsu. Global stability of a delayed multi-group SIRS epidemic model with nonlinear incidence rates and relapse of infection. Discrete & Continuous Dynamical Systems - B, 2015, 20 (9) : 3057-3091. doi: 10.3934/dcdsb.2015.20.3057 [2] Jinliang Wang, Xianning Liu, Toshikazu Kuniya, Jingmei Pang. Global stability for multi-group SIR and SEIR epidemic models with age-dependent susceptibility. Discrete & Continuous Dynamical Systems - B, 2017, 22 (7) : 2795-2812. doi: 10.3934/dcdsb.2017151 [3] Toshikazu Kuniya, Jinliang Wang, Hisashi Inaba. A multi-group SIR epidemic model with age structure. Discrete & Continuous Dynamical Systems - B, 2016, 21 (10) : 3515-3550. doi: 10.3934/dcdsb.2016109 [4] Jinhu Xu, Yicang Zhou. Global stability of a multi-group model with generalized nonlinear incidence and vaccination age. Discrete & Continuous Dynamical Systems - B, 2016, 21 (3) : 977-996. doi: 10.3934/dcdsb.2016.21.977 [5] Jinhu Xu, Yicang Zhou. Global stability of a multi-group model with vaccination age, distributed delay and random perturbation. Mathematical Biosciences & Engineering, 2015, 12 (5) : 1083-1106. doi: 10.3934/mbe.2015.12.1083 [6] Jinliang Wang, Hongying Shu. Global analysis on a class of multi-group SEIR model with latency and relapse. Mathematical Biosciences & Engineering, 2016, 13 (1) : 209-225. doi: 10.3934/mbe.2016.13.209 [7] Xiaomei Feng, Zhidong Teng, Fengqin Zhang. Global dynamics of a general class of multi-group epidemic models with latency and relapse. Mathematical Biosciences & Engineering, 2015, 12 (1) : 99-115. doi: 10.3934/mbe.2015.12.99 [8] Gunduz Caginalp, Mark DeSantis. Multi-group asset flow equations and stability. Discrete & Continuous Dynamical Systems - B, 2011, 16 (1) : 109-150. doi: 10.3934/dcdsb.2011.16.109 [9] Yoshiaki Muroya. A Lotka-Volterra system with patch structure (related to a multi-group SI epidemic model). Discrete & Continuous Dynamical Systems - S, 2015, 8 (5) : 999-1008. doi: 10.3934/dcdss.2015.8.999 [10] Lili Liu, Xianning Liu, Jinliang Wang. Threshold dynamics of a delayed multi-group heroin epidemic model in heterogeneous populations. Discrete & Continuous Dynamical Systems - B, 2016, 21 (8) : 2615-2630. doi: 10.3934/dcdsb.2016064 [11] Chunmei Zhang, Wenxue Li, Ke Wang. Graph-theoretic approach to stability of multi-group models with dispersal. Discrete & Continuous Dynamical Systems - B, 2015, 20 (1) : 259-280. doi: 10.3934/dcdsb.2015.20.259 [12] Deqiong Ding, Wendi Qin, Xiaohua Ding. Lyapunov functions and global stability for a discretized multigroup SIR epidemic model. Discrete & Continuous Dynamical Systems - B, 2015, 20 (7) : 1971-1981. doi: 10.3934/dcdsb.2015.20.1971 [13] Jianquan Li, Zhien Ma. Stability analysis for SIS epidemic models with vaccination and constant population size. Discrete & Continuous Dynamical Systems - B, 2004, 4 (3) : 635-642. doi: 10.3934/dcdsb.2004.4.635 [14] Shouying Huang, Jifa Jiang. Global stability of a network-based SIS epidemic model with a general nonlinear incidence rate. Mathematical Biosciences & Engineering, 2016, 13 (4) : 723-739. doi: 10.3934/mbe.2016016 [15] Attila Dénes, Yoshiaki Muroya, Gergely Röst. Global stability of a multistrain SIS model with superinfection. Mathematical Biosciences & Engineering, 2017, 14 (2) : 421-435. doi: 10.3934/mbe.2017026 [16] Rui Wang, Xiaoyue Li, Denis S. Mukama. On stochastic multi-group Lotka-Volterra ecosystems with regime switching. Discrete & Continuous Dynamical Systems - B, 2017, 22 (9) : 3499-3528. doi: 10.3934/dcdsb.2017177 [17] Yukihiko Nakata, Yoichi Enatsu, Yoshiaki Muroya. On the global stability of an SIRS epidemic model with distributed delays. Conference Publications, 2011, 2011 (Special) : 1119-1128. doi: 10.3934/proc.2011.2011.1119 [18] Toshikazu Kuniya, Mimmo Iannelli. $R_0$ and the global behavior of an age-structured SIS epidemic model with periodicity and vertical transmission. Mathematical Biosciences & Engineering, 2014, 11 (4) : 929-945. doi: 10.3934/mbe.2014.11.929 [19] Jia-Feng Cao, Wan-Tong Li, Fei-Ying Yang. Dynamics of a nonlocal SIS epidemic model with free boundary. Discrete & Continuous Dynamical Systems - B, 2017, 22 (2) : 247-266. doi: 10.3934/dcdsb.2017013 [20] Wei Ding, Wenzhang Huang, Siroj Kansakar. Traveling wave solutions for a diffusive sis epidemic model. Discrete & Continuous Dynamical Systems - B, 2013, 18 (5) : 1291-1304. doi: 10.3934/dcdsb.2013.18.1291

2018 Impact Factor: 1.008