# American Institute of Mathematical Sciences

October  2014, 19(8): 2657-2679. doi: 10.3934/dcdsb.2014.19.2657

## Sufficient conditions for strong local optimality in optimal control problems with $L_{2}$-type objectives and control constraints

 1 Dept. of Electrical and Systems Engineering, Washington University, St. Louis, Missouri, 63130-4899 2 Dept. of Mathematics and Statistics, Southern Illinois University Edwardsville, Edwardsville, Illinois, 62026-1653 3 Institut für Numerische und Angewandte Mathematik, Westfälische Wilhelms Universität Münster, D-48149 Münster, Germany

Received  November 2013 Revised  January 2014 Published  August 2014

We consider the optimal control problem of minimizing an objective function that is quadratic in the control over a fixed interval for a multi-input bilinear dynamical system in the presence of control constraints. Such models are motivated by and applied to mathematical models for cancer chemotherapy over an a priori specified fixed therapy horizon. The necessary conditions for optimality of the Pontryagin maximum principle are easily evaluated and give a functional description of optimal controls as continuous functions of states and multipliers. However, there is no a priori guarantee that a numerically computed extremal controlled trajectory is locally optimal. In this paper, we formulate sufficient conditions for strong local optimality that are based on the existence of a bounded solution to a matrix Riccati differential equation. The theory is applied to a $3$-compartment model for multi-drug cancer chemotherapy with cytotoxic and cytostatic agents. The numerical results are compared with those for a corresponding optimal control problem when the objective is taken linear in the controls.
Citation: Heinz Schättler, Urszula Ledzewicz, Helmut Maurer. Sufficient conditions for strong local optimality in optimal control problems with $L_{2}$-type objectives and control constraints. Discrete & Continuous Dynamical Systems - B, 2014, 19 (8) : 2657-2679. doi: 10.3934/dcdsb.2014.19.2657
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##### References:
 [1] Vaibhav Mehandiratta, Mani Mehra, Günter Leugering. Fractional optimal control problems on a star graph: Optimality system and numerical solution. Mathematical Control & Related Fields, 2021, 11 (1) : 189-209. doi: 10.3934/mcrf.2020033 [2] Christian Clason, Vu Huu Nhu, Arnd Rösch. Optimal control of a non-smooth quasilinear elliptic equation. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020052 [3] Zuliang Lu, Fei Huang, Xiankui Wu, Lin Li, Shang Liu. Convergence and quasi-optimality of $L^2-$norms based an adaptive finite element method for nonlinear optimal control problems. Electronic Research Archive, 2020, 28 (4) : 1459-1486. doi: 10.3934/era.2020077 [4] Manil T. Mohan. First order necessary conditions of optimality for the two dimensional tidal dynamics system. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020045 [5] Roland Schnaubelt, Martin Spitz. Local wellposedness of quasilinear Maxwell equations with absorbing boundary conditions. Evolution Equations & Control Theory, 2021, 10 (1) : 155-198. doi: 10.3934/eect.2020061 [6] Hong Niu, Zhijiang Feng, Qijin Xiao, Yajun Zhang. A PID control method based on optimal control strategy. Numerical Algebra, Control & Optimization, 2021, 11 (1) : 117-126. doi: 10.3934/naco.2020019 [7] Thierry Cazenave, Ivan Naumkin. Local smooth solutions of the nonlinear Klein-gordon equation. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020448 [8] Lars Grüne, Matthias A. Müller, Christopher M. Kellett, Steven R. Weller. Strict dissipativity for discrete time discounted optimal control problems. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020046 [9] Hai Huang, Xianlong Fu. Optimal control problems for a neutral integro-differential system with infinite delay. Evolution Equations & Control Theory, 2020  doi: 10.3934/eect.2020107 [10] Hongbo Guan, Yong Yang, Huiqing Zhu. A nonuniform anisotropic FEM for elliptic boundary layer optimal control problems. Discrete & Continuous Dynamical Systems - B, 2021, 26 (3) : 1711-1722. doi: 10.3934/dcdsb.2020179 [11] Leilei Wei, Yinnian He. A fully discrete local discontinuous Galerkin method with the generalized numerical flux to solve the tempered fractional reaction-diffusion equation. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020319 [12] Yueh-Cheng Kuo, Huey-Er Lin, Shih-Feng Shieh. Asymptotic dynamics of hermitian Riccati difference equations. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020365 [13] Youming Guo, Tingting Li. Optimal control strategies for an online game addiction model with low and high risk exposure. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020347 [14] Pierluigi Colli, Gianni Gilardi, Jürgen Sprekels. Deep quench approximation and optimal control of general Cahn–Hilliard systems with fractional operators and double obstacle potentials. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 243-271. doi: 10.3934/dcdss.2020213 [15] Stefan Doboszczak, Manil T. Mohan, Sivaguru S. Sritharan. Pontryagin maximum principle for the optimal control of linearized compressible navier-stokes equations with state constraints. Evolution Equations & Control Theory, 2020  doi: 10.3934/eect.2020110 [16] Elimhan N. Mahmudov. Infimal convolution and duality in convex optimal control problems with second order evolution differential inclusions. Evolution Equations & Control Theory, 2021, 10 (1) : 37-59. doi: 10.3934/eect.2020051 [17] Lars Grüne, Roberto Guglielmi. On the relation between turnpike properties and dissipativity for continuous time linear quadratic optimal control problems. Mathematical Control & Related Fields, 2021, 11 (1) : 169-188. doi: 10.3934/mcrf.2020032 [18] Jingrui Sun, Hanxiao Wang. Mean-field stochastic linear-quadratic optimal control problems: Weak closed-loop solvability. Mathematical Control & Related Fields, 2021, 11 (1) : 47-71. doi: 10.3934/mcrf.2020026 [19] Arthur Fleig, Lars Grüne. Strict dissipativity analysis for classes of optimal control problems involving probability density functions. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020053 [20] Urszula Ledzewicz, Heinz Schättler. On the role of pharmacometrics in mathematical models for cancer treatments. Discrete & Continuous Dynamical Systems - B, 2021, 26 (1) : 483-499. doi: 10.3934/dcdsb.2020213

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