September  2020, 25(9): 3609-3630. doi: 10.3934/dcdsb.2020075

Influence of mutations in phenotypically-structured populations in time periodic environment

1. 

Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal

2. 

Laboratoire Jacques-Louis Lions, 5 place Jussieu, 75005 Paris, France

* Corresponding author: cmcarrere@igc.gulbenkian.pt

Received  August 2019 Revised  October 2019 Published  January 2020

Fund Project: This work was partially supported by grants from Région Ile-de-France and Inria team Mamba

We study a parabolic Lotka-Volterra equation, with an integral term representing competition, and time periodic growth rate. This model represents a trait structured population in a time periodic environment. After showing the convergence of the solution to the unique positive and periodic solution of the problem, we study the influence of different factors on the mean limit population. As this quantity is the opposite of a certain eigenvalue, we are able to investigate the influence of the diffusion rate, the period length and the time variance of the environment fluctuations. We also give biological interpretation of the results in the framework of cancer, if the model represents a cancerous cells population under the influence of a periodic treatment. In this framework, we show that the population might benefit from a intermediate rate of mutation.

Citation: Cécile Carrère, Grégoire Nadin. Influence of mutations in phenotypically-structured populations in time periodic environment. Discrete & Continuous Dynamical Systems - B, 2020, 25 (9) : 3609-3630. doi: 10.3934/dcdsb.2020075
References:
[1]

M. Alfaro and M. Veruete, Evolutionary branching via replicator mutator equations, Journal of Dynamics and Differential Equations, 31 (2019), 2029-2052.  doi: 10.1007/s10884-018-9692-9.  Google Scholar

[2]

A. Ardaševa, R. A. Gatenby, A. R. A. Anderson, H. M. Byrne, P. K. Maini and T. Lorenzi, Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments, 2019, arXiv: 1905.11712. Google Scholar

[3]

D. BasantaH. Hatzikirou and A. Deutsch, Studying the emergence of invasiveness in tumours using game theory, The European Physical Journal B, 63 (2008), 393-397.  doi: 10.1140/epjb/e2008-00249-y.  Google Scholar

[4]

P. L. BedardA. R. HansenM. J. Ratain and L. L. Siu, Tumour heterogeneity in the clinic, Nature, 501 (2013), 355-364.  doi: 10.1038/nature12627.  Google Scholar

[5]

H. BerestyckiF. Hamel and L. Roques, Analysis of the periodically fragmented environment model: Ⅰ-species persistence, Journal of Mathematical Biology, 51 (2005), 75-113.  doi: 10.1007/s00285-004-0313-3.  Google Scholar

[6]

H. BerestyckiF. Hamel and L. Roques, Analysis of the periodically fragmented environment model: Ⅱ-biological invasions and pulsating travelling fronts, Journal de Mathématiques Pures et Appliquées, 84 (2005), 1101-1146.  doi: 10.1016/j.matpur.2004.10.006.  Google Scholar

[7]

A. Calsina and S. Cuadrado, Small mutation rate and evolutionarily stable strategies in infinite dimensional adaptive dynamics, Journal of Mathematical Biology, 48 (2004), 135-159.  doi: 10.1007/s00285-003-0226-6.  Google Scholar

[8]

R. S. Cantrell and C. Cosner, Diffusive logistic equations with indefinite weights: Population models in disrupted environments Ⅱ, SIAM Journal on Mathematical Analysis, 22 (1991), 1043-1064.  doi: 10.1137/0522068.  Google Scholar

[9]

N. Champagnat, R. Ferrière and S. Méléard, Individual-based probabilistic models of adaptive evolution and various scaling approximations, In Seminar on Stochastic Analysis, Random Fields and Applications V, Springer, 59 (2008), 75–113. doi: 10.1007/978-3-7643-8458-6_6.  Google Scholar

[10]

N. Champagnat and A. Lambert, Evolution of discrete populations and the canonical diffusion of adaptive dynamics, The Annals of Applied Probability, 17 (2007), 102-155.  doi: 10.1214/105051606000000628.  Google Scholar

[11]

J. Coville., Convergence to equilibrium for positive solutions of some mutation-selection model., arXiv: 1308.6471 [math], 2013, arXiv: 1308.6471. Google Scholar

[12]

L. DesvillettesP. E. JabinS. Mischler and G. Raoul, On selection dynamics for continuous structured populations, Communications in Mathematical Sciences, 6 (2008), 729-747.  doi: 10.4310/CMS.2008.v6.n3.a10.  Google Scholar

[13]

T. Epstein, R. A. Gatenby and J. S. Brown, The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand, PLOS ONE, 12 (2017), e0185085. doi: 10.1371/journal.pone.0185085.  Google Scholar

[14]

S. Figueroa Iglesias and S. Mirrahimi, Long time evolutionary dynamics of phenotypically structured populations in time-periodic environments, SIAM Journal on Mathematical Analysis, 50 (2018), 5537-5568.  doi: 10.1137/18M1175185.  Google Scholar

[15]

S. Geritz, Evolution and the theory of games, Evolution and the Theory of Games, 2011, page 6. Google Scholar

[16]

C. A. GravenmierM. Siddique and R. A. Gatenby, Adaptation to stochastic temporal variations in intratumoral blood flow: The warburg effect as a bet hedging strategy, Bulletin of Mathematical Biology, 80 (2018), 954-970.  doi: 10.1007/s11538-017-0261-x.  Google Scholar

[17]

P. Hess, Periodic-parabolic Boundary Value Problems and Positivity, Longman Scientific & Technical, 1991.  Google Scholar

[18]

D. Horvath and B. Brutovsky, Study of selected phenotype switching strategies in time varying environment, Physics Letters A, 380 (2016), 1267-1278.  doi: 10.1016/j.physleta.2016.01.037.  Google Scholar

[19]

J. Hùska, Harnack inequality and exponential separation for oblique derivative problems on lipschitz domains, Journal of Differential Equations, 226 (2006), 541-557.  doi: 10.1016/j.jde.2006.02.008.  Google Scholar

[20]

V. HutsonK. Mischaikow and P. Polik, The evolution of dispersal rates in a heterogeneous time-periodic environment, Journal of Mathematical Biology, 43 (2001), 501-533.  doi: 10.1007/s002850100106.  Google Scholar

[21]

V. HutsonW. Shen and G. Vickers, Estimates for the principal spectrum point for certain time-dependent parabolic operators, Proceedings of the American Mathematical Society, 129 (2001), 1669-1679.  doi: 10.1090/S0002-9939-00-05808-1.  Google Scholar

[22]

E. Kisdi, Dispersal: Risk spreading versus local adaptation, The American Naturalist, 159 (2002), 579-596.  doi: 10.1086/339989.  Google Scholar

[23]

E. Kisdi, Conditional dispersal under kin competition: Extension of the hamiltonmay model to brood size-dependent dispersal, Theoretical Population Biology, 66 (2004), 369-380.  doi: 10.1016/j.tpb.2004.06.009.  Google Scholar

[24]

U. LedzewiczH. SchttlerM. R. Gahrooi and S. M. Dehkordi, On the MTD paradigm and optimal control for multi-drug cancer chemotherapy, Mathematical Biosciences and Engineering, 10 (2013), 803-819.  doi: 10.3934/mbe.2013.10.803.  Google Scholar

[25]

S. Liu, Y. Lou, R. Peng and M. Zhou, Monotonicity of the principal eigenvalue for a linear time-periodic parabolic operator, Proc. Amer. Math. Soc., 147 (2019), 5291–5302, arXiv: 1903.11757. doi: 10.1090/proc/14653.  Google Scholar

[26]

T. LorenziR. H. ChisholmL. Desvillettes and B. D. Hughes, Dissecting the dynamics of epigenetic changes in phenotype-structured populations exposed to fluctuating environments, Journal of Theoretical Biology, 386 (2015), 166-176.  doi: 10.1016/j.jtbi.2015.08.031.  Google Scholar

[27]

G. Nadin, The principal eigenvalue of a spacetime periodic parabolic operator, Annali di Matematica Pura ed Applicata, 188 (2009), 269-295.  doi: 10.1007/s10231-008-0075-4.  Google Scholar

[28]

G. Nadin, Some dependence results between the spreading speed and the coefficients of the spacetime periodic FisherKPP equation, European Journal of Applied Mathematics, 22 (2011), 169-185.  doi: 10.1017/S0956792511000027.  Google Scholar

[29]

R. Peng and X.-Q. Zhao, Effects of diffusion and advection on the principal eigenvalue of a periodic-parabolic problem with applications, Calculus of Variations and Partial Differential Equations, 54 (2015), 1611-1642.  doi: 10.1007/s00526-015-0838-x.  Google Scholar

[30]

B. Perthame, Transport Equations in Biology, Springer Science & Business Media, 2007.  Google Scholar

[31]

A. O. Pisco, A. Brock, J. Zhou, A. Moor, M. Mojtahedi, D. Jackson and S. Huang, Non-Darwinian dynamics in therapy-induced cancer drug resistance, Nature Communications, 4 (2013), Article number: 2467. doi: 10.1038/ncomms3467.  Google Scholar

[32]

C. PoucholJ. ClairambaultA. Lorz and E. Trlat, Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy, Journal de Mathmatiques Pures et Appliques, 116 (2018), 268-308.  doi: 10.1016/j.matpur.2017.10.007.  Google Scholar

show all references

References:
[1]

M. Alfaro and M. Veruete, Evolutionary branching via replicator mutator equations, Journal of Dynamics and Differential Equations, 31 (2019), 2029-2052.  doi: 10.1007/s10884-018-9692-9.  Google Scholar

[2]

A. Ardaševa, R. A. Gatenby, A. R. A. Anderson, H. M. Byrne, P. K. Maini and T. Lorenzi, Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments, 2019, arXiv: 1905.11712. Google Scholar

[3]

D. BasantaH. Hatzikirou and A. Deutsch, Studying the emergence of invasiveness in tumours using game theory, The European Physical Journal B, 63 (2008), 393-397.  doi: 10.1140/epjb/e2008-00249-y.  Google Scholar

[4]

P. L. BedardA. R. HansenM. J. Ratain and L. L. Siu, Tumour heterogeneity in the clinic, Nature, 501 (2013), 355-364.  doi: 10.1038/nature12627.  Google Scholar

[5]

H. BerestyckiF. Hamel and L. Roques, Analysis of the periodically fragmented environment model: Ⅰ-species persistence, Journal of Mathematical Biology, 51 (2005), 75-113.  doi: 10.1007/s00285-004-0313-3.  Google Scholar

[6]

H. BerestyckiF. Hamel and L. Roques, Analysis of the periodically fragmented environment model: Ⅱ-biological invasions and pulsating travelling fronts, Journal de Mathématiques Pures et Appliquées, 84 (2005), 1101-1146.  doi: 10.1016/j.matpur.2004.10.006.  Google Scholar

[7]

A. Calsina and S. Cuadrado, Small mutation rate and evolutionarily stable strategies in infinite dimensional adaptive dynamics, Journal of Mathematical Biology, 48 (2004), 135-159.  doi: 10.1007/s00285-003-0226-6.  Google Scholar

[8]

R. S. Cantrell and C. Cosner, Diffusive logistic equations with indefinite weights: Population models in disrupted environments Ⅱ, SIAM Journal on Mathematical Analysis, 22 (1991), 1043-1064.  doi: 10.1137/0522068.  Google Scholar

[9]

N. Champagnat, R. Ferrière and S. Méléard, Individual-based probabilistic models of adaptive evolution and various scaling approximations, In Seminar on Stochastic Analysis, Random Fields and Applications V, Springer, 59 (2008), 75–113. doi: 10.1007/978-3-7643-8458-6_6.  Google Scholar

[10]

N. Champagnat and A. Lambert, Evolution of discrete populations and the canonical diffusion of adaptive dynamics, The Annals of Applied Probability, 17 (2007), 102-155.  doi: 10.1214/105051606000000628.  Google Scholar

[11]

J. Coville., Convergence to equilibrium for positive solutions of some mutation-selection model., arXiv: 1308.6471 [math], 2013, arXiv: 1308.6471. Google Scholar

[12]

L. DesvillettesP. E. JabinS. Mischler and G. Raoul, On selection dynamics for continuous structured populations, Communications in Mathematical Sciences, 6 (2008), 729-747.  doi: 10.4310/CMS.2008.v6.n3.a10.  Google Scholar

[13]

T. Epstein, R. A. Gatenby and J. S. Brown, The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand, PLOS ONE, 12 (2017), e0185085. doi: 10.1371/journal.pone.0185085.  Google Scholar

[14]

S. Figueroa Iglesias and S. Mirrahimi, Long time evolutionary dynamics of phenotypically structured populations in time-periodic environments, SIAM Journal on Mathematical Analysis, 50 (2018), 5537-5568.  doi: 10.1137/18M1175185.  Google Scholar

[15]

S. Geritz, Evolution and the theory of games, Evolution and the Theory of Games, 2011, page 6. Google Scholar

[16]

C. A. GravenmierM. Siddique and R. A. Gatenby, Adaptation to stochastic temporal variations in intratumoral blood flow: The warburg effect as a bet hedging strategy, Bulletin of Mathematical Biology, 80 (2018), 954-970.  doi: 10.1007/s11538-017-0261-x.  Google Scholar

[17]

P. Hess, Periodic-parabolic Boundary Value Problems and Positivity, Longman Scientific & Technical, 1991.  Google Scholar

[18]

D. Horvath and B. Brutovsky, Study of selected phenotype switching strategies in time varying environment, Physics Letters A, 380 (2016), 1267-1278.  doi: 10.1016/j.physleta.2016.01.037.  Google Scholar

[19]

J. Hùska, Harnack inequality and exponential separation for oblique derivative problems on lipschitz domains, Journal of Differential Equations, 226 (2006), 541-557.  doi: 10.1016/j.jde.2006.02.008.  Google Scholar

[20]

V. HutsonK. Mischaikow and P. Polik, The evolution of dispersal rates in a heterogeneous time-periodic environment, Journal of Mathematical Biology, 43 (2001), 501-533.  doi: 10.1007/s002850100106.  Google Scholar

[21]

V. HutsonW. Shen and G. Vickers, Estimates for the principal spectrum point for certain time-dependent parabolic operators, Proceedings of the American Mathematical Society, 129 (2001), 1669-1679.  doi: 10.1090/S0002-9939-00-05808-1.  Google Scholar

[22]

E. Kisdi, Dispersal: Risk spreading versus local adaptation, The American Naturalist, 159 (2002), 579-596.  doi: 10.1086/339989.  Google Scholar

[23]

E. Kisdi, Conditional dispersal under kin competition: Extension of the hamiltonmay model to brood size-dependent dispersal, Theoretical Population Biology, 66 (2004), 369-380.  doi: 10.1016/j.tpb.2004.06.009.  Google Scholar

[24]

U. LedzewiczH. SchttlerM. R. Gahrooi and S. M. Dehkordi, On the MTD paradigm and optimal control for multi-drug cancer chemotherapy, Mathematical Biosciences and Engineering, 10 (2013), 803-819.  doi: 10.3934/mbe.2013.10.803.  Google Scholar

[25]

S. Liu, Y. Lou, R. Peng and M. Zhou, Monotonicity of the principal eigenvalue for a linear time-periodic parabolic operator, Proc. Amer. Math. Soc., 147 (2019), 5291–5302, arXiv: 1903.11757. doi: 10.1090/proc/14653.  Google Scholar

[26]

T. LorenziR. H. ChisholmL. Desvillettes and B. D. Hughes, Dissecting the dynamics of epigenetic changes in phenotype-structured populations exposed to fluctuating environments, Journal of Theoretical Biology, 386 (2015), 166-176.  doi: 10.1016/j.jtbi.2015.08.031.  Google Scholar

[27]

G. Nadin, The principal eigenvalue of a spacetime periodic parabolic operator, Annali di Matematica Pura ed Applicata, 188 (2009), 269-295.  doi: 10.1007/s10231-008-0075-4.  Google Scholar

[28]

G. Nadin, Some dependence results between the spreading speed and the coefficients of the spacetime periodic FisherKPP equation, European Journal of Applied Mathematics, 22 (2011), 169-185.  doi: 10.1017/S0956792511000027.  Google Scholar

[29]

R. Peng and X.-Q. Zhao, Effects of diffusion and advection on the principal eigenvalue of a periodic-parabolic problem with applications, Calculus of Variations and Partial Differential Equations, 54 (2015), 1611-1642.  doi: 10.1007/s00526-015-0838-x.  Google Scholar

[30]

B. Perthame, Transport Equations in Biology, Springer Science & Business Media, 2007.  Google Scholar

[31]

A. O. Pisco, A. Brock, J. Zhou, A. Moor, M. Mojtahedi, D. Jackson and S. Huang, Non-Darwinian dynamics in therapy-induced cancer drug resistance, Nature Communications, 4 (2013), Article number: 2467. doi: 10.1038/ncomms3467.  Google Scholar

[32]

C. PoucholJ. ClairambaultA. Lorz and E. Trlat, Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy, Journal de Mathmatiques Pures et Appliques, 116 (2018), 268-308.  doi: 10.1016/j.matpur.2017.10.007.  Google Scholar

Figure 1.  Proliferation and sensitivity functions chosen for the simulations
figure 3">Figure 2.  Final mean populations $ \bar{\rho}_N $ represented as functions of the mutation rate $ D $ for various treatment schedules. The treatments are of the form $ C(t) = \mathbf{1}_{0\leq t \leq \tau}M/\tau $, with $ M = 2 $ and $ \tau $ varying between $ 1/4 $ and $ T = 2 $. Populations $ A $, $ B $ and $ C $ are detailed in figure 3
figure 2 are detailed for $ \tau = 1/4 $. We represent the population repartition in phenotypes just before treatment, just after treatment and the mean population">Figure 3.  Populations $ A $, $ B $ and $ C $ of figure 2 are detailed for $ \tau = 1/4 $. We represent the population repartition in phenotypes just before treatment, just after treatment and the mean population
Figure 4.  Illustration of the conjecture that $ \bar{\rho}_N $ is a decreasing function of the time of drug administration $ \tau $. These numerical simulations were performed for $ T = 2 $
Figure 5.  Illustration of Proposition 4 on the influence of $ T $ on the population size. These numerical simulations were performed for $ \tau = T/2 $ and a fixed diffusion coefficient $ D = 0.1 $
Figure 6.  Mean limit population $ \bar{\rho}_N $ as a function of both diffusion and drug dosage per period $ M $
Figure 7.  Populations for random changing of environment with same mean value
[1]

Qiang Guo, Dong Liang. An adaptive wavelet method and its analysis for parabolic equations. Numerical Algebra, Control & Optimization, 2013, 3 (2) : 327-345. doi: 10.3934/naco.2013.3.327

[2]

Ankit Kumar, Kamal Jeet, Ramesh Kumar Vats. Controllability of Hilfer fractional integro-differential equations of Sobolev-type with a nonlocal condition in a Banach space. Evolution Equations & Control Theory, 2021  doi: 10.3934/eect.2021016

[3]

Hongjie Dong, Xinghong Pan. On conormal derivative problem for parabolic equations with Dini mean oscillation coefficients. Discrete & Continuous Dynamical Systems, 2021  doi: 10.3934/dcds.2021049

[4]

Pengyu Chen. Periodic solutions to non-autonomous evolution equations with multi-delays. Discrete & Continuous Dynamical Systems - B, 2021, 26 (6) : 2921-2939. doi: 10.3934/dcdsb.2020211

[5]

Amru Hussein, Martin Saal, Marc Wrona. Primitive equations with horizontal viscosity: The initial value and The time-periodic problem for physical boundary conditions. Discrete & Continuous Dynamical Systems, 2021, 41 (7) : 3063-3092. doi: 10.3934/dcds.2020398

[6]

Leon Mons. Partial regularity for parabolic systems with VMO-coefficients. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2021041

[7]

V. Vijayakumar, R. Udhayakumar, K. Kavitha. On the approximate controllability of neutral integro-differential inclusions of Sobolev-type with infinite delay. Evolution Equations & Control Theory, 2021, 10 (2) : 271-296. doi: 10.3934/eect.2020066

[8]

Nikolaos Roidos. Expanding solutions of quasilinear parabolic equations. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2021026

[9]

Nizami A. Gasilov. Solving a system of linear differential equations with interval coefficients. Discrete & Continuous Dynamical Systems - B, 2021, 26 (5) : 2739-2747. doi: 10.3934/dcdsb.2020203

[10]

Pengyu Chen. Non-autonomous stochastic evolution equations with nonlinear noise and nonlocal conditions governed by noncompact evolution families. Discrete & Continuous Dynamical Systems, 2021, 41 (6) : 2725-3737. doi: 10.3934/dcds.2020383

[11]

Flank D. M. Bezerra, Jacson Simsen, Mariza Stefanello Simsen. Convergence of quasilinear parabolic equations to semilinear equations. Discrete & Continuous Dynamical Systems - B, 2021, 26 (7) : 3823-3834. doi: 10.3934/dcdsb.2020258

[12]

Anderson L. A. de Araujo, Marcelo Montenegro. Existence of solution and asymptotic behavior for a class of parabolic equations. Communications on Pure & Applied Analysis, 2021, 20 (3) : 1213-1227. doi: 10.3934/cpaa.2021017

[13]

Siqi Chen, Yong-Kui Chang, Yanyan Wei. Pseudo $ S $-asymptotically Bloch type periodic solutions to a damped evolution equation. Evolution Equations & Control Theory, 2021  doi: 10.3934/eect.2021017

[14]

Bernold Fiedler, Carlos Rocha, Matthias Wolfrum. Sturm global attractors for $S^1$-equivariant parabolic equations. Networks & Heterogeneous Media, 2012, 7 (4) : 617-659. doi: 10.3934/nhm.2012.7.617

[15]

Zhang Chao, Minghua Yang. BMO type space associated with Neumann operator and application to a class of parabolic equations. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021104

[16]

Jaume Llibre, Luci Any Roberto. On the periodic solutions of a class of Duffing differential equations. Discrete & Continuous Dynamical Systems, 2013, 33 (1) : 277-282. doi: 10.3934/dcds.2013.33.277

[17]

Tôn Việt Tạ. Strict solutions to stochastic semilinear evolution equations in M-type 2 Banach spaces. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2021050

[18]

Misha Perepelitsa. A model of cultural evolution in the context of strategic conflict. Kinetic & Related Models, , () : -. doi: 10.3934/krm.2021014

[19]

Marcel Braukhoff, Ansgar Jüngel. Entropy-dissipating finite-difference schemes for nonlinear fourth-order parabolic equations. Discrete & Continuous Dynamical Systems - B, 2021, 26 (6) : 3335-3355. doi: 10.3934/dcdsb.2020234

[20]

Lianbing She, Nan Liu, Xin Li, Renhai Wang. Three types of weak pullback attractors for lattice pseudo-parabolic equations driven by locally Lipschitz noise. Electronic Research Archive, , () : -. doi: 10.3934/era.2021028

2019 Impact Factor: 1.27

Metrics

  • PDF downloads (182)
  • HTML views (368)
  • Cited by (1)

Other articles
by authors

[Back to Top]