In this paper, we first establish a version of the Feynman-Kac formula for the tempered fractional general diffusion equation
$ \begin{align} \partial^{\beta, \eta}_{t} u(t,x) = \mathfrak{L}u(t,x) +b(t)u(t,x),\; \; x\in\mathcal{X},\; t\geq0, \end{align} $
with initial value
$ \begin{align} u(t,x) = {\mathbb{E}}^{x}\bigg[f(X_{D_{\beta,\eta}(t)}) e^{\int_{0}^{t}b(r)dD_{\beta,\eta}(r)}\bigg] \end{align} $
is the unique mild and weak solutions to the tempered fractional general diffusion equation. From the Feynman-Kac formula, we further show the continuity of the solution with respect to time based on the integral properties of the Mittag-Leffler function and differential formula of covariance for
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