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doi: 10.3934/dcdss.2020011

Global asymptotic stability in a chemotaxis-growth model for tumor invasion

Kentarou Fujie ,

Department of Mathematics, Tokyo University of Science, Tokyo 162-8601, Japan

* Corresponding author: Kentarou Fujie

Received  May 2017 Revised  December 2017 Published  January 2019

This paper presents global existence and asymptotic behavior of solutions to the chemotaxis-growth system
$ \left\{ \begin{array}{l} u_t = \Delta u - \nabla \cdot (u\nabla v) + ru -\mu u^\alpha, \qquad x\in \Omega, \ t>0, \\ \ v_t = \Delta v + wz, \qquad x\in \Omega, \ t>0, \\ \ w_t = -wz, \qquad x\in \Omega, \ t>0, \\ \ z_t = \Delta z - z + u, \qquad x\in \Omega, \ t>0, \end{array} \right. $
in a smoothly bounded domain
$ \Omega \subset \mathbb{R}^n $
,
$ n \le 3 $
, where
$ r>0 $
,
$ \mu>0 $
 and
$ \alpha>1 $
. Without the logistic source
$ ru-\mu u^\alpha $
, the stabilization of this system has been shown by Fujie, Ito, Winkler and Yokota (2016), whereas especially about asymptotic behavior, the logistic source disturbs applying this method directly. In the present paper, a way out of this difficulty is introduced and the asymptotic behavior of solutions to the system with logistic source is precisely determined.
Keywords: Chemotaxis, asymptotic behavior, tumor invasion.
Mathematics Subject Classification: Primary: 35B40, 35Q92; Secondary: 92C17.
Citation: Kentarou Fujie. Global asymptotic stability in a chemotaxis-growth model for tumor invasion. Discrete & Continuous Dynamical Systems - S, doi: 10.3934/dcdss.2020011
References:
[1]

N. Bellomo, A. Bellouquid, Y. Tao and M. Winkler, Toward a mathematical theory of Keller-Segel models of pattern formation in biological tissues, Math. Models Methods Appl. Sci., 25 (2015), 1663-1763. doi: 10.1142/S021820251550044X. Google Scholar

[2]

X. Cao, Global bounded solutions of the higher-dimensional Keller-Segel system under smallness conditions in optimal spaces, Discrete Contin. Dyn. Syst., 35 (2015), 1891-1904. doi: 10.3934/dcds.2015.35.1891. Google Scholar

[3]

M. A. J. Chaplain and A. R. A. Anderson, Mathematical modelling of tissue invasion, in Cancer modelling and simulation, Chapman & Hall/CRC Math. Biol. Med. Ser., Chapman & Hall/CRC, Boca Raton, FL, (2003), 269-297. Google Scholar

[4]

E. Feireisl, P. Laurençot and H. Petzeltová, On convergence to equilibria for the Keller-Segel chemotaxis model, J. Differential Equations, 236 (2007), 551-569. doi: 10.1016/j.jde.2007.02.002. Google Scholar

[5]

A. Friedman and J. I. Tello, Stability of solutions of chemotaxis equations in reinforced random walks, J. Math. Anal. Appl., 272 (2002), 138-163. doi: 10.1016/S0022-247X(02)00147-6. Google Scholar

[6]

K. Fujie, A. Ito and T. Yokota, Existence and uniqueness of local classical solutions to modified tumor invasion models of Chaplain-Anderson type, Adv. Math. Sci. Appl., 24 (2014), 67-84. Google Scholar

[7]

K. Fujie, A. Ito, M. Winkler and T. Yokota, Stabilization in a chemotaxis model for tumor invasion, Discrete Contin. Dyn. Syst., 36 (2016), 151-169. doi: 10.3934/dcds.2016.36.151. Google Scholar

[8]

K. Fujie and T. Senba, Application of an Adams type inequality to a two-chemical substances chemotaxis system, J. Differential Equations, 263 (2017), 88-148. doi: 10.1016/j.jde.2017.02.031. Google Scholar

[9]

M. A. Herrero and J. J. L. Velázquez, A blow-up mechanism for a chemotaxis model, Ann. Scuola Norm. Sup. Pisa Cl. Sci., 24 (1997), 633-683. Google Scholar

[10]

T. Hillen and K. J. Painter, A user's guide to PDE models for chemotaxis, J. Math. Biol., 58 (2009), 183-217. doi: 10.1007/s00285-008-0201-3. Google Scholar

[11]

D. Horstmann, From 1970 until present: The Keller-Segel model in chemotaxis and its consequences. I, Jahresber. Deutsch. Math.-Verein., 105 (2003), 103-165. Google Scholar

[12]

B. Hu and Y. Tao, To the exclusion of blow-up in a three-dimensional chemotaxis-growth model with indirect attractant production, Math. Models Methods Appl. Sci., 26 (2016), 2111-2128. doi: 10.1142/S0218202516400091. Google Scholar

[13]

K. Kang, A. Stevens and J. J. L. Velázquez, Qualitative behavior of a Keller-Segel model with non-diffusive memory, Commun. Partial Differ. Equations, 35 (2010), 245-274. doi: 10.1080/03605300903473400. Google Scholar

[14]

E. F. Keller and L. A. Segel, Initiation of slime mold aggregation viewed as an instability, J. Theor. Biol., 26 (1970), 399-415. doi: 10.1016/0022-5193(70)90092-5. Google Scholar

[15]

O. A. Ladyzenskaja, V. A. Solonnikov and N. N. Ural'ceva, Linear and Quasi-Linear Equations of Parabolic Type, Amer. Math. Soc. Transl., Vol. 23, Providence, RI, 1968. Google Scholar

[16]

J. Lankeit, Eventual smoothness and asymptotics in a three-dimensional chemotaxis system with logistic source, J. Differential Equations, 258 (2015), 1158-1191. doi: 10.1016/j.jde.2014.10.016. Google Scholar

[17]

G. Liţcanu and C. Morales-Rodrigo, Asymptotic behaviour of global solutions to a model of cell invasion, Math. Mod. Meth. Appl. Sci., 20 (2010), 1721-1758. doi: 10.1142/S0218202510004775. Google Scholar

[18]

A. Marciniak-Czochra and M. Ptashnyk, Boundedness of solutions of a haptotaxis model, Math. Models Methods Appl. Sci., 20 (2010), 449-476. doi: 10.1142/S0218202510004301. Google Scholar

[19]

C. Morales-Rodrigo, Local existence and uniqueness of regular solutions in a model of tissue invasion by solid tumours, Math. Comput. Modelling, 47 (2008), 604-613. doi: 10.1016/j.mcm.2007.02.031. Google Scholar

[20]

K. Osaki, T. Tsujikawa, A. Yagi and M. Mimura, Exponential attractor for a chemotaxis-growth system of equations, Nonlinear Anal., Theory Methods Appl., 51 (2002), 119-144. doi: 10.1016/S0362-546X(01)00815-X. Google Scholar

[21]

K. Osaki and A. Yagi, Finite dimensional attractor for one-dimensional Keller-Segel equations, Funkcialaj Ekvacioj, 44 (2001), 441-469. Google Scholar

[22]

Z. Szymańska, C. Morales-Rodrigo, M. Lachowicz and M. A. J. Chaplain, Mathematical modelling of cancer invasion of tissue: The role and effect of nonlocal interactions, Math. Models Methods Appl. Sci., 19 (2009), 257-281. doi: 10.1142/S0218202509003425. Google Scholar

[23]

Y. Tao, Global existence for a haptotaxis model of cancer invasion with tissue remodeling, Nonlinear Anal. Real World Appl., 12 (2011), 418-435. doi: 10.1016/j.nonrwa.2010.06.027. Google Scholar

[24]

Y. Tao and M. Winkler, Critical mass for infinite-time aggregation in a chemotaxis model with indirect signal production, J. Eur. Math. Soc.(JEMS), 19 (2017), 3641-3678. doi: 10.4171/JEMS/749. Google Scholar

[25]

J. I. Tello and M. Winkler, A chemotaxis system with logistic source, Comm. Partial Differential Equations, 32 (2007), 849-877. doi: 10.1080/03605300701319003. Google Scholar

[26]

J. I. Tello and D. Wrzosek, Predator-prey model with diffusion and indirect prey-taxis, Math. Models Methods Appl. Sci., 26 (2016), 2129-2162. doi: 10.1142/S0218202516400108. Google Scholar

[27]

C. Walker and G. F. Webb, Global existence of classical solutions for a haptotaxis model, SIAM J. Math. Anal., 38 (2007), 1694-1713. doi: 10.1137/060655122. Google Scholar

[28]

M. Winkler, Boundedness in the higher-dimensional parabolic-parabolic chemotaxis system with logistic source, Comm. Partial Differential Equations, 35 (2010), 1516-1537. doi: 10.1080/03605300903473426. Google Scholar

[29]

M. Winkler, Finite-time blow-up in the higher-dimensional parabolic-parabolic Keller-Segel system, Journal de Mathématiques Pures et Appliquées, 100 (2013), 748-767. doi: 10.1016/j.matpur.2013.01.020. Google Scholar

[30]

M. Winkler, Global asymptotic stability of constant equilibria in a fully parabolic chemotaxis system with strong logistic dampening, J. Differential Equations, 257 (2014), 1056-1077. doi: 10.1016/j.jde.2014.04.023. Google Scholar

show all references

References:
[1]

N. Bellomo, A. Bellouquid, Y. Tao and M. Winkler, Toward a mathematical theory of Keller-Segel models of pattern formation in biological tissues, Math. Models Methods Appl. Sci., 25 (2015), 1663-1763. doi: 10.1142/S021820251550044X. Google Scholar

[2]

X. Cao, Global bounded solutions of the higher-dimensional Keller-Segel system under smallness conditions in optimal spaces, Discrete Contin. Dyn. Syst., 35 (2015), 1891-1904. doi: 10.3934/dcds.2015.35.1891. Google Scholar

[3]

M. A. J. Chaplain and A. R. A. Anderson, Mathematical modelling of tissue invasion, in Cancer modelling and simulation, Chapman & Hall/CRC Math. Biol. Med. Ser., Chapman & Hall/CRC, Boca Raton, FL, (2003), 269-297. Google Scholar

[4]

E. Feireisl, P. Laurençot and H. Petzeltová, On convergence to equilibria for the Keller-Segel chemotaxis model, J. Differential Equations, 236 (2007), 551-569. doi: 10.1016/j.jde.2007.02.002. Google Scholar

[5]

A. Friedman and J. I. Tello, Stability of solutions of chemotaxis equations in reinforced random walks, J. Math. Anal. Appl., 272 (2002), 138-163. doi: 10.1016/S0022-247X(02)00147-6. Google Scholar

[6]

K. Fujie, A. Ito and T. Yokota, Existence and uniqueness of local classical solutions to modified tumor invasion models of Chaplain-Anderson type, Adv. Math. Sci. Appl., 24 (2014), 67-84. Google Scholar

[7]

K. Fujie, A. Ito, M. Winkler and T. Yokota, Stabilization in a chemotaxis model for tumor invasion, Discrete Contin. Dyn. Syst., 36 (2016), 151-169. doi: 10.3934/dcds.2016.36.151. Google Scholar

[8]

K. Fujie and T. Senba, Application of an Adams type inequality to a two-chemical substances chemotaxis system, J. Differential Equations, 263 (2017), 88-148. doi: 10.1016/j.jde.2017.02.031. Google Scholar

[9]

M. A. Herrero and J. J. L. Velázquez, A blow-up mechanism for a chemotaxis model, Ann. Scuola Norm. Sup. Pisa Cl. Sci., 24 (1997), 633-683. Google Scholar

[10]

T. Hillen and K. J. Painter, A user's guide to PDE models for chemotaxis, J. Math. Biol., 58 (2009), 183-217. doi: 10.1007/s00285-008-0201-3. Google Scholar

[11]

D. Horstmann, From 1970 until present: The Keller-Segel model in chemotaxis and its consequences. I, Jahresber. Deutsch. Math.-Verein., 105 (2003), 103-165. Google Scholar

[12]

B. Hu and Y. Tao, To the exclusion of blow-up in a three-dimensional chemotaxis-growth model with indirect attractant production, Math. Models Methods Appl. Sci., 26 (2016), 2111-2128. doi: 10.1142/S0218202516400091. Google Scholar

[13]

K. Kang, A. Stevens and J. J. L. Velázquez, Qualitative behavior of a Keller-Segel model with non-diffusive memory, Commun. Partial Differ. Equations, 35 (2010), 245-274. doi: 10.1080/03605300903473400. Google Scholar

[14]

E. F. Keller and L. A. Segel, Initiation of slime mold aggregation viewed as an instability, J. Theor. Biol., 26 (1970), 399-415. doi: 10.1016/0022-5193(70)90092-5. Google Scholar

[15]

O. A. Ladyzenskaja, V. A. Solonnikov and N. N. Ural'ceva, Linear and Quasi-Linear Equations of Parabolic Type, Amer. Math. Soc. Transl., Vol. 23, Providence, RI, 1968. Google Scholar

[16]

J. Lankeit, Eventual smoothness and asymptotics in a three-dimensional chemotaxis system with logistic source, J. Differential Equations, 258 (2015), 1158-1191. doi: 10.1016/j.jde.2014.10.016. Google Scholar

[17]

G. Liţcanu and C. Morales-Rodrigo, Asymptotic behaviour of global solutions to a model of cell invasion, Math. Mod. Meth. Appl. Sci., 20 (2010), 1721-1758. doi: 10.1142/S0218202510004775. Google Scholar

[18]

A. Marciniak-Czochra and M. Ptashnyk, Boundedness of solutions of a haptotaxis model, Math. Models Methods Appl. Sci., 20 (2010), 449-476. doi: 10.1142/S0218202510004301. Google Scholar

[19]

C. Morales-Rodrigo, Local existence and uniqueness of regular solutions in a model of tissue invasion by solid tumours, Math. Comput. Modelling, 47 (2008), 604-613. doi: 10.1016/j.mcm.2007.02.031. Google Scholar

[20]

K. Osaki, T. Tsujikawa, A. Yagi and M. Mimura, Exponential attractor for a chemotaxis-growth system of equations, Nonlinear Anal., Theory Methods Appl., 51 (2002), 119-144. doi: 10.1016/S0362-546X(01)00815-X. Google Scholar

[21]

K. Osaki and A. Yagi, Finite dimensional attractor for one-dimensional Keller-Segel equations, Funkcialaj Ekvacioj, 44 (2001), 441-469. Google Scholar

[22]

Z. Szymańska, C. Morales-Rodrigo, M. Lachowicz and M. A. J. Chaplain, Mathematical modelling of cancer invasion of tissue: The role and effect of nonlocal interactions, Math. Models Methods Appl. Sci., 19 (2009), 257-281. doi: 10.1142/S0218202509003425. Google Scholar

[23]

Y. Tao, Global existence for a haptotaxis model of cancer invasion with tissue remodeling, Nonlinear Anal. Real World Appl., 12 (2011), 418-435. doi: 10.1016/j.nonrwa.2010.06.027. Google Scholar

[24]

Y. Tao and M. Winkler, Critical mass for infinite-time aggregation in a chemotaxis model with indirect signal production, J. Eur. Math. Soc.(JEMS), 19 (2017), 3641-3678. doi: 10.4171/JEMS/749. Google Scholar

[25]

J. I. Tello and M. Winkler, A chemotaxis system with logistic source, Comm. Partial Differential Equations, 32 (2007), 849-877. doi: 10.1080/03605300701319003. Google Scholar

[26]

J. I. Tello and D. Wrzosek, Predator-prey model with diffusion and indirect prey-taxis, Math. Models Methods Appl. Sci., 26 (2016), 2129-2162. doi: 10.1142/S0218202516400108. Google Scholar

[27]

C. Walker and G. F. Webb, Global existence of classical solutions for a haptotaxis model, SIAM J. Math. Anal., 38 (2007), 1694-1713. doi: 10.1137/060655122. Google Scholar

[28]

M. Winkler, Boundedness in the higher-dimensional parabolic-parabolic chemotaxis system with logistic source, Comm. Partial Differential Equations, 35 (2010), 1516-1537. doi: 10.1080/03605300903473426. Google Scholar

[29]

M. Winkler, Finite-time blow-up in the higher-dimensional parabolic-parabolic Keller-Segel system, Journal de Mathématiques Pures et Appliquées, 100 (2013), 748-767. doi: 10.1016/j.matpur.2013.01.020. Google Scholar

[30]

M. Winkler, Global asymptotic stability of constant equilibria in a fully parabolic chemotaxis system with strong logistic dampening, J. Differential Equations, 257 (2014), 1056-1077. doi: 10.1016/j.jde.2014.04.023. Google Scholar

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