# American Institute of Mathematical Sciences

## Mathematical modelling of cytosolic calcium concentration distribution using non-local fractional operator

 1 Department of Mathematics, Malaviya National Institute of Technology, Jaipur-302017, INDIA 2 Department of HEAS(Mathematics), RTU, Kota-324010, INDIA 3 Department of Mathematics, University of Rajasthan, Jaipur 302004, Rajasthan, India

* Corresponding author: Devendra Kumar

Received  October 2019 Revised  December 2019 Published  March 2021

The aim of this paper is to study the calcium profile governed by the advection diffusion equation. The mathematical and computational modeling has provided insights to understand the calcium signalling which depends upon cytosolic calcium concentration. Here the model includes the important physiological parameters like diffusion coefficient, flow velocity etc. The mathematical model is fractionalised using Hilfer derivative and appropriate boundary conditions have been framed. The use of fractional order derivative is more advantageous than the integer order because of the non-local property of the fractional order differentiation operator i.e. the next state of the system depends not only upon its current state but also upon all of its preceeding states. Analytic solution of the fractional advection diffusion equation arising in study of diffusion of cytosolic calcium in RBC is found using integral transform techniques. Since, the Hilfer derivative is generalisation of Riemann- Liouville and Caputo derivatives so, these two are also deduced as special cases. The numerical simulation has been done to observe the effects of the fractional order of the derivatives involved in the differential equation representing the model over the concentration of calcium which is function of time and distance. The concentration profile of calcium is significantly changed by the fractional order.

Citation: Ritu Agarwal, Kritika, Sunil Dutt Purohit, Devendra Kumar. Mathematical modelling of cytosolic calcium concentration distribution using non-local fractional operator. Discrete & Continuous Dynamical Systems - S, doi: 10.3934/dcdss.2021017
##### References:

show all references

##### References:
Graph between $C(x, t)$ and $t$ for various values of $\xi$ for $\eta = 0$ which corresponds to the Riemann- Liouville derivative
Graph between $C(x, t)$ and t for various values of $\xi$ for $\eta = 1$ which corresponds to Caputo derivative
Graph between $C(x, t)$ and t for various values of $\xi$ for $\eta = 0.90$
 [1] Alberto Ibort, Alberto López-Yela. Quantum tomography and the quantum Radon transform. Inverse Problems & Imaging, , () : -. doi: 10.3934/ipi.2021021 [2] Umberto Biccari. Internal control for a non-local Schrödinger equation involving the fractional Laplace operator. Evolution Equations & Control Theory, 2021  doi: 10.3934/eect.2021014 [3] George A. Anastassiou. Iyengar-Hilfer fractional inequalities. Mathematical Foundations of Computing, 2021  doi: 10.3934/mfc.2021004 [4] Changpin Li, Zhiqiang Li. Asymptotic behaviors of solution to partial differential equation with Caputo–Hadamard derivative and fractional Laplacian: Hyperbolic case. Discrete & Continuous Dynamical Systems - S, 2021  doi: 10.3934/dcdss.2021023 [5] Yan Zhang, Peibiao Zhao, Xinghu Teng, Lei Mao. Optimal reinsurance and investment strategies for an insurer and a reinsurer under Hestons SV model: HARA utility and Legendre transform. Journal of Industrial & Management Optimization, 2021, 17 (4) : 2139-2159. doi: 10.3934/jimo.2020062 [6] Dan Wei, Shangjiang Guo. Qualitative analysis of a Lotka-Volterra competition-diffusion-advection system. Discrete & Continuous Dynamical Systems - B, 2021, 26 (5) : 2599-2623. doi: 10.3934/dcdsb.2020197 [7] Haili Qiao, Aijie Cheng. A fast high order method for time fractional diffusion equation with non-smooth data. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021073 [8] Ankit Kumar, Kamal Jeet, Ramesh Kumar Vats. Controllability of Hilfer fractional integro-differential equations of Sobolev-type with a nonlocal condition in a Banach space. Evolution Equations & Control Theory, 2021  doi: 10.3934/eect.2021016 [9] Bo Duan, Zhengce Zhang. A reaction-diffusion-advection two-species competition system with a free boundary in heterogeneous environment. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021067 [10] Renhao Cui. Asymptotic profiles of the endemic equilibrium of a reaction-diffusion-advection SIS epidemic model with saturated incidence rate. Discrete & Continuous Dynamical Systems - B, 2021, 26 (6) : 2997-3022. doi: 10.3934/dcdsb.2020217 [11] Pavel I. Naumkin, Isahi Sánchez-Suárez. Asymptotics for the higher-order derivative nonlinear Schrödinger equation. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2021028 [12] Andreia Chapouto. A remark on the well-posedness of the modified KdV equation in the Fourier-Lebesgue spaces. Discrete & Continuous Dynamical Systems, 2021, 41 (8) : 3915-3950. doi: 10.3934/dcds.2021022 [13] Simone Cacace, Maurizio Falcone. A dynamic domain decomposition for the eikonal-diffusion equation. Discrete & Continuous Dynamical Systems - S, 2016, 9 (1) : 109-123. doi: 10.3934/dcdss.2016.9.109 [14] Kin Ming Hui, Soojung Kim. Asymptotic large time behavior of singular solutions of the fast diffusion equation. Discrete & Continuous Dynamical Systems, 2017, 37 (11) : 5943-5977. doi: 10.3934/dcds.2017258 [15] Mohamed Ouzahra. Approximate controllability of the semilinear reaction-diffusion equation governed by a multiplicative control. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021081 [16] Meng-Xue Chang, Bang-Sheng Han, Xiao-Ming Fan. Global dynamics of the solution for a bistable reaction diffusion equation with nonlocal effect. Electronic Research Archive, , () : -. doi: 10.3934/era.2021024 [17] Amit Goswami, Sushila Rathore, Jagdev Singh, Devendra Kumar. Analytical study of fractional nonlinear Schrödinger equation with harmonic oscillator. Discrete & Continuous Dynamical Systems - S, 2021  doi: 10.3934/dcdss.2021021 [18] Shoichi Hasegawa, Norihisa Ikoma, Tatsuki Kawakami. On weak solutions to a fractional Hardy–Hénon equation: Part I: Nonexistence. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2021033 [19] Yingdan Ji, Wen Tan. Global well-posedness of a 3D Stokes-Magneto equations with fractional magnetic diffusion. Discrete & Continuous Dynamical Systems - B, 2021, 26 (6) : 3271-3278. doi: 10.3934/dcdsb.2020227 [20] Yongqiang Fu, Xiaoju Zhang. Global existence and asymptotic behavior of weak solutions for time-space fractional Kirchhoff-type diffusion equations. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021091

2019 Impact Factor: 1.233

## Tools

Article outline

Figures and Tables