The main purpose of the present paper is to study the blow-up problem of the wave equation with space-dependent damping in the scale-invariant case and time derivative nonlinearity with small initial data. Under appropriate initial data which are compactly supported, by using a test function method and taking into account the effect of the damping term ($ \frac{\mu}{\sqrt{1+|x|^2}}u_t $), we show that in higher dimensions the blow-up region is given by $ p \in (1, p_G(N+\mu)] $ where $ p_G(N) $ is the Glassey exponent. Furthermore, we shall establish a blow-up region, independent of $ \mu $ given by $ p\in (1, 1+\frac{2}{N}), $ for appropriate initial data in the energy space with noncompact support.
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