This paper is concerned with solving some fundamental estimation, prediction, and inference problems on a linear random-effects model with its parameter vector satisfying certain exact linear restrictions. Our work includes deriving analytical formulas for calculating the best linear unbiased predictors (BLUPs) and the best linear unbiased estimators (BLUEs) of all unknown parameters in the model by way of solving certain constrained quadratic matrix optimization problems, characterizing various mathematical and statistical properties of the predictors and estimators, establishing various fundamental rank and inertia formulas associated with the covariance matrices of predictors and estimators, and presenting necessary and sufficient conditions for several equalities and inequalities of covariance matrices of the predictors and estimators to hold.
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