We present a general approach to proving the existence of spectral gaps and asynchronous exponential growth for growth-fragmentation semigroups in moment spaces $ L^{1}( \mathbb{R} _{+};\ x^{\alpha }dx) $ and $ L^{1}( \mathbb{R} _{+};\ \left( 1+x\right) ^{\alpha }dx) $ for unbounded total fragmentation rates and continuous growth rates $ r(.) $ such that $ \int_{0}^{+\infty } \frac{1}{r(\tau )}d\tau = +\infty .\ $ The analysis is based on weak compactness tools and Frobenius theory of positive operators and holds provided that $ \alpha >\widehat{\alpha } $ for a suitable threshold $ \widehat{ \alpha }\geq 1 $ that depends on the moment space we consider. A systematic functional analytic construction is provided. Various examples of fragmentation kernels illustrating the theory are given and an open problem is mentioned.
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