American Institute of Mathematical Sciences

Advanced
2004, 1(1): 147-159. doi: 10.3934/mbe.2004.1.147

Biological computing with diffusion and excitable calcium stores

H. G. E. Hentschel 1, , Alan Fine 2, and  C. S. Pencea 3,

1. 

Department of Physics, Emory University, Maths/Science Center, 400 Dowman Drive, Atlanta, GA 30322, United States
2. 

Department of Physiology and Biophysics, Dalhousie University, Halifax NS, Canada
3. 

Department of Physics, Emory University, Atlanta, GA 30322, United States

Received  February 2004 Revised  March 2004 Published  March 2004

Intracellular signaling often employs excitable stores of calcium coupled by diffusion. We investigate the ability of various geometric configurations of such excitable stores to generate a complete set of logic gates for computation. We also describe how the mechanism of excitable calcium-induced calcium release can be used for constructing coincidence detectors for biological signals.
Keywords: Biological Signaling., Diffusion, Logic Gates, Computation, Calcium-Induced Calcium Release.
Mathematics Subject Classification: 92C05, 92C5.
Citation: H. G. E. Hentschel, Alan Fine, C. S. Pencea. Biological computing with diffusion and excitable calcium stores. Mathematical Biosciences & Engineering, 2004, 1 (1) : 147-159. doi: 10.3934/mbe.2004.1.147
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