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The Influence of PK/PD on the Structure of Optimal Controls in Cancer Chemotherapy Models
| 1. | Department of Mathematics and Statistics, Southern Illinois University at Edwardsville, Edwardsville, IL 62026-1653 |
| 2. | Dept. of Electrical and Systems Engineering, Washington University, St. Louis, Missouri, 63130-4899 |
| [1] |
Urszula Ledzewicz, Heinz Schättler. Drug resistance in cancer chemotherapy as an optimal control problem. Discrete & Continuous Dynamical Systems - B, 2006, 6 (1) : 129-150. doi: 10.3934/dcdsb.2006.6.129 |
| [2] |
Wei Feng, Shuhua Hu, Xin Lu. Optimal controls for a 3-compartment model for cancer chemotherapy with quadratic objective. Conference Publications, 2003, 2003 (Special) : 544-553. doi: 10.3934/proc.2003.2003.544 |
| [3] |
Urszula Ledzewicz, Heinz Schättler, Mostafa Reisi Gahrooi, Siamak Mahmoudian Dehkordi. On the MTD paradigm and optimal control for multi-drug cancer chemotherapy. Mathematical Biosciences & Engineering, 2013, 10 (3) : 803-819. doi: 10.3934/mbe.2013.10.803 |
| [4] |
Shuo Wang, Heinz Schättler. Optimal control of a mathematical model for cancer chemotherapy under tumor heterogeneity. Mathematical Biosciences & Engineering, 2016, 13 (6) : 1223-1240. doi: 10.3934/mbe.2016040 |
| [5] |
Luis A. Fernández, Cecilia Pola. Catalog of the optimal controls in cancer chemotherapy for the Gompertz model depending on PK/PD and the integral constraint. Discrete & Continuous Dynamical Systems - B, 2014, 19 (6) : 1563-1588. doi: 10.3934/dcdsb.2014.19.1563 |
| [6] |
Shuo Wang, Heinz Schättler. Optimal control for cancer chemotherapy under tumor heterogeneity with Michealis-Menten pharmacodynamics. Discrete & Continuous Dynamical Systems - B, 2019, 24 (5) : 2383-2405. doi: 10.3934/dcdsb.2019100 |
| [7] |
Urszula Ledzewicz, Heinz Schättler, Shuo Wang. On the role of tumor heterogeneity for optimal cancer chemotherapy. Networks & Heterogeneous Media, 2019, 14 (1) : 131-147. doi: 10.3934/nhm.2019007 |
| [8] |
Urszula Ledzewicz, Heinz Schättler. Controlling a model for bone marrow dynamics in cancer chemotherapy. Mathematical Biosciences & Engineering, 2004, 1 (1) : 95-110. doi: 10.3934/mbe.2004.1.95 |
| [9] |
Clara Rojas, Juan Belmonte-Beitia, Víctor M. Pérez-García, Helmut Maurer. Dynamics and optimal control of chemotherapy for low grade gliomas: Insights from a mathematical model. Discrete & Continuous Dynamical Systems - B, 2016, 21 (6) : 1895-1915. doi: 10.3934/dcdsb.2016028 |
| [10] |
Arturo Alvarez-Arenas, Konstantin E. Starkov, Gabriel F. Calvo, Juan Belmonte-Beitia. Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy. Discrete & Continuous Dynamical Systems - B, 2019, 24 (5) : 2017-2038. doi: 10.3934/dcdsb.2019082 |
| [11] |
Craig Collins, K. Renee Fister, Bethany Key, Mary Williams. Blasting neuroblastoma using optimal control of chemotherapy. Mathematical Biosciences & Engineering, 2009, 6 (3) : 451-467. doi: 10.3934/mbe.2009.6.451 |
| [12] |
Urszula Ledzewicz, Behrooz Amini, Heinz Schättler. Dynamics and control of a mathematical model for metronomic chemotherapy. Mathematical Biosciences & Engineering, 2015, 12 (6) : 1257-1275. doi: 10.3934/mbe.2015.12.1257 |
| [13] |
Urszula Ledzewicz, Mozhdeh Sadat Faraji Mosalman, Heinz Schättler. Optimal controls for a mathematical model of tumor-immune interactions under targeted chemotherapy with immune boost. Discrete & Continuous Dynamical Systems - B, 2013, 18 (4) : 1031-1051. doi: 10.3934/dcdsb.2013.18.1031 |
| [14] |
Joseph Malinzi, Rachid Ouifki, Amina Eladdadi, Delfim F. M. Torres, K. A. Jane White. Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis. Mathematical Biosciences & Engineering, 2018, 15 (6) : 1435-1463. doi: 10.3934/mbe.2018066 |
| [15] |
Urszula Ledzewicz, Shuo Wang, Heinz Schättler, Nicolas André, Marie Amélie Heng, Eddy Pasquier. On drug resistance and metronomic chemotherapy: A mathematical modeling and optimal control approach. Mathematical Biosciences & Engineering, 2017, 14 (1) : 217-235. doi: 10.3934/mbe.2017014 |
| [16] |
Shanjian Tang. A second-order maximum principle for singular optimal stochastic controls. Discrete & Continuous Dynamical Systems - B, 2010, 14 (4) : 1581-1599. doi: 10.3934/dcdsb.2010.14.1581 |
| [17] |
Urszula Ledzewicz, Heinz Schättler. On optimal singular controls for a general SIR-model with vaccination and treatment. Conference Publications, 2011, 2011 (Special) : 981-990. doi: 10.3934/proc.2011.2011.981 |
| [18] |
Piotr Bajger, Mariusz Bodzioch, Urszula Foryś. Singularity of controls in a simple model of acquired chemotherapy resistance. Discrete & Continuous Dynamical Systems - B, 2019, 24 (5) : 2039-2052. doi: 10.3934/dcdsb.2019083 |
| [19] |
M. Delgado-Téllez, Alberto Ibort. On the geometry and topology of singular optimal control problems and their solutions. Conference Publications, 2003, 2003 (Special) : 223-233. doi: 10.3934/proc.2003.2003.223 |
| [20] |
Nacira Agram, Astrid Hilbert, Bernt Øksendal. Singular control of SPDEs with space-mean dynamics. Mathematical Control & Related Fields, 2020, 10 (2) : 425-441. doi: 10.3934/mcrf.2020004 |
2018 Impact Factor: 1.313
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