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Modeling Multicellular Systems Using Subcellular Elements
The Role Of Time Delays, Slow Processes And Chaos In Modulating The Cell-Cycle Clock
1. | Volcani Center, Gilat Experiment Station, Negev 4, 85280, Israel |
2. | Institute for Medical Biomathematics, PO Box 282, 10, Hate'ena St., Bene Ataroth, 60991, Israel |
We hypothesize that the existence of such a reservoir is advantageous in morphogenetic tissues, such as the bone marrow, as it enables time- and site-specific selection of the optimal cell-cycle period for any specific micro- environment. This can be obtained by the addition of a time delay in the autocatalytic reaction, reflecting, for example, the influence of external molecular signals on cell-cycle progression.
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