The Role Of Time Delays, Slow Processes And Chaos In Modulating The Cell-Cycle Clock
Volcani Center, Gilat Experiment Station, Negev 4, 85280, Israel
Institute for Medical Biomathematics, PO Box 282, 10, Hate'ena St., Bene Ataroth, 60991, Israel
We hypothesize that the existence of such a reservoir is advantageous in morphogenetic tissues, such as the bone marrow, as it enables time- and site-specific selection of the optimal cell-cycle period for any specific micro- environment. This can be obtained by the addition of a time delay in the autocatalytic reaction, reflecting, for example, the influence of external molecular signals on cell-cycle progression.
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