Advanced Search
Article Contents
Article Contents

An in vivo intermediate filament assembly model

Abstract Related Papers Cited by
  • A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equilibrium. By means of sensitivity analysis, the influence of parameters on the system is studied. It is shown that, in agreement with biological observations, posttranslational modifications of intermediate filament proteins resulting in filament solubilization are the main regulators of the intermediate filament organization. A high signalling-dependent solubilization of filaments favours the intermediate filament aggregation in particles.
    Mathematics Subject Classification: Primary: 92C37.


    \begin{equation} \\ \end{equation}
  • 加载中

Article Metrics

HTML views() PDF downloads(64) Cited by(0)

Access History

Other Articles By Authors



    DownLoad:  Full-Size Img  PowerPoint