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  • Those of us who met the field of mathematical biology as a well-developed, flourishing, and rewarding discipline owe much to those who made it so. This special issue of Mathematical Biosciences and Engineering is dedicated to two such pioneers: Fred Brauer and Karl Hadeler. Since retrospectives of both men have been published in other venues [1, 2], we will only summarize their contributions briefly here.
    Fred Brauer obtained his Ph.D. from MIT in 1956 under Norman Levinson, and during a long tenure at the University of Wisconsin he co-wrote several texts on ordinary differential equations that have become classics. His research entered mathematical biology first through early studies in predator-prey systems and harvesting, both with and without delays. He then moved into mathematical epidemiology, and the text he co-authored with Carlos Castillo-Chavez in both these areas earlier this decade is already in wide use.

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