2009, 6(2): 321-332. doi: 10.3934/mbe.2009.6.321

Epidemic models with differential susceptibility and staged progression and their dynamics

1. 

Theoretical Division, MS-B284, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, United States

2. 

Department of Mathematical Sciences, University of Alabama in Huntsville, Huntsville, AL 35899

Received  December 2007 Revised  July 2008 Published  March 2009

We formulate and study epidemic models with differential susceptibilities and staged-progressions, based on systems of ordinary differential equations, for disease transmission where the susceptibility of susceptible individuals vary and the infective individuals progress the disease gradually through stages with different infectiousness in each stage. We consider the contact rates to be proportional to the total population or constant such that the infection rates have a bilinear or standard form, respectively. We derive explicit formulas for the reproductive number $R_0$, and show that the infection-free equilibrium is globally asymptotically stable if $R_0<1$ when the infection rate has a bilinear form. We investigate existence of the endemic equilibrium for the two cases and show that there exists a unique endemic equilibrium for the bilinear incidence, and at least one endemic equilibrium for the standard incidence when $R_0>1$.
Citation: James M. Hyman, Jia Li. Epidemic models with differential susceptibility and staged progression and their dynamics. Mathematical Biosciences & Engineering, 2009, 6 (2) : 321-332. doi: 10.3934/mbe.2009.6.321
[1]

Hongbin Guo, Michael Yi Li. Global dynamics of a staged progression model for infectious diseases. Mathematical Biosciences & Engineering, 2006, 3 (3) : 513-525. doi: 10.3934/mbe.2006.3.513

[2]

Andrey V. Melnik, Andrei Korobeinikov. Global asymptotic properties of staged models with multiple progression pathways for infectious diseases. Mathematical Biosciences & Engineering, 2011, 8 (4) : 1019-1034. doi: 10.3934/mbe.2011.8.1019

[3]

Timothy C. Reluga, Jan Medlock, Alison Galvani. The discounted reproductive number for epidemiology. Mathematical Biosciences & Engineering, 2009, 6 (2) : 377-393. doi: 10.3934/mbe.2009.6.377

[4]

James M. Hyman, Jia Li. Differential susceptibility and infectivity epidemic models. Mathematical Biosciences & Engineering, 2006, 3 (1) : 89-100. doi: 10.3934/mbe.2006.3.89

[5]

Andrey V. Melnik, Andrei Korobeinikov. Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility. Mathematical Biosciences & Engineering, 2013, 10 (2) : 369-378. doi: 10.3934/mbe.2013.10.369

[6]

Jinliang Wang, Xianning Liu, Toshikazu Kuniya, Jingmei Pang. Global stability for multi-group SIR and SEIR epidemic models with age-dependent susceptibility. Discrete & Continuous Dynamical Systems - B, 2017, 22 (7) : 2795-2812. doi: 10.3934/dcdsb.2017151

[7]

Ariel Cintrón-Arias, Carlos Castillo-Chávez, Luís M. A. Bettencourt, Alun L. Lloyd, H. T. Banks. The estimation of the effective reproductive number from disease outbreak data. Mathematical Biosciences & Engineering, 2009, 6 (2) : 261-282. doi: 10.3934/mbe.2009.6.261

[8]

Maoxing Liu, Yuming Chen. An SIRS model with differential susceptibility and infectivity on uncorrelated networks. Mathematical Biosciences & Engineering, 2015, 12 (3) : 415-429. doi: 10.3934/mbe.2015.12.415

[9]

Junya Nishiguchi. On parameter dependence of exponential stability of equilibrium solutions in differential equations with a single constant delay. Discrete & Continuous Dynamical Systems - A, 2016, 36 (10) : 5657-5679. doi: 10.3934/dcds.2016048

[10]

Marc Briant. Stability of global equilibrium for the multi-species Boltzmann equation in $L^\infty$ settings. Discrete & Continuous Dynamical Systems - A, 2016, 36 (12) : 6669-6688. doi: 10.3934/dcds.2016090

[11]

Pierre Magal. Global stability for differential equations with homogeneous nonlinearity and application to population dynamics. Discrete & Continuous Dynamical Systems - B, 2002, 2 (4) : 541-560. doi: 10.3934/dcdsb.2002.2.541

[12]

Bao-Zhu Guo, Li-Ming Cai. A note for the global stability of a delay differential equation of hepatitis B virus infection. Mathematical Biosciences & Engineering, 2011, 8 (3) : 689-694. doi: 10.3934/mbe.2011.8.689

[13]

Anatoli F. Ivanov, Musa A. Mammadov. Global asymptotic stability in a class of nonlinear differential delay equations. Conference Publications, 2011, 2011 (Special) : 727-736. doi: 10.3934/proc.2011.2011.727

[14]

Xiong Li. The stability of the equilibrium for a perturbed asymmetric oscillator. Communications on Pure & Applied Analysis, 2006, 5 (3) : 515-528. doi: 10.3934/cpaa.2006.5.515

[15]

Xiong Li. The stability of the equilibrium for a perturbed asymmetric oscillator. Communications on Pure & Applied Analysis, 2007, 6 (1) : 69-82. doi: 10.3934/cpaa.2007.6.69

[16]

Esther Chigidi, Edward M. Lungu. HIV model incorporating differential progression for treatment-naive and treatment-experienced infectives. Mathematical Biosciences & Engineering, 2009, 6 (3) : 427-450. doi: 10.3934/mbe.2009.6.427

[17]

Alain Bensoussan, Jens Frehse, Christine Grün. Stochastic differential games with a varying number of players. Communications on Pure & Applied Analysis, 2014, 13 (5) : 1719-1736. doi: 10.3934/cpaa.2014.13.1719

[18]

Anna Ghazaryan, Christopher K. R. T. Jones. On the stability of high Lewis number combustion fronts. Discrete & Continuous Dynamical Systems - A, 2009, 24 (3) : 809-826. doi: 10.3934/dcds.2009.24.809

[19]

Tarik Mohammed Touaoula. Global stability for a class of functional differential equations (Application to Nicholson's blowflies and Mackey-Glass models). Discrete & Continuous Dynamical Systems - A, 2018, 38 (9) : 4391-4419. doi: 10.3934/dcds.2018191

[20]

Franco Maceri, Michele Marino, Giuseppe Vairo. Equilibrium and stability of tensegrity structures: A convex analysis approach. Discrete & Continuous Dynamical Systems - S, 2013, 6 (2) : 461-478. doi: 10.3934/dcdss.2013.6.461

2018 Impact Factor: 1.313

Metrics

  • PDF downloads (4)
  • HTML views (0)
  • Cited by (0)

Other articles
by authors

[Back to Top]