• Previous Article
    New developments in using stochastic recipe for multi-compartment model: Inter-compartment traveling route, residence time, and exponential convolution expansion
  • MBE Home
  • This Issue
  • Next Article
    Feedback stabilization for a chemostat with delayed output
2009, 6(3): 649-661. doi: 10.3934/mbe.2009.6.649

A model for transmission of partial resistance to anti-malarial drugs

1. 

Industrial and Financial Mathematics Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132, Indonesia, Indonesia, Indonesia

2. 

Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta 10430, Indonesia

3. 

United States Naval Medical Research Unit 2, Jl. Percetakan Negara 29, Jakarta 10560, Indonesia

Received  November 2008 Revised  February 2009 Published  June 2009

Anti-malarial drug resistance has been identified in many regions for a long time. In this paper we formulate a mathematical model of the spread of anti-malarial drug resistance in the population. The model is suitable for malarial situations in developing countries. We consider the sensitive and resistant strains of malaria. There are two basic reproduction ratios corresponding to the strains. If the ratios corresponding to the infections of the sensitive and resistant strains are not equal and they are greater than one, then there exist two endemic non-coexistent equilibria. In the case where the two ratios are equal and they are greater than one, the coexistence of the sensitive and resistant strains exist in the population. It is shown here that the recovery rates of the infected host and the proportion of anti-malarial drug treatment play important roles in the spread of anti-malarial drug resistance. The interesting phenomena of ''long-time" coexistence, which may explain the real situation in the field, could occur for long period of time when those parameters satisfy certain conditions. In regards to control strategy in the field, these results could give a good understanding of means of slowing down the spread of anti-malarial drug resistance.
Citation: Hengki Tasman, Edy Soewono, Kuntjoro Adji Sidarto, Din Syafruddin, William Oscar Rogers. A model for transmission of partial resistance to anti-malarial drugs. Mathematical Biosciences & Engineering, 2009, 6 (3) : 649-661. doi: 10.3934/mbe.2009.6.649
[1]

Fanni M. Sélley. A self-consistent dynamical system with multiple absolutely continuous invariant measures. Journal of Computational Dynamics, 2021, 8 (1) : 9-32. doi: 10.3934/jcd.2021002

[2]

Min Chen, Olivier Goubet, Shenghao Li. Mathematical analysis of bump to bucket problem. Communications on Pure & Applied Analysis, 2020, 19 (12) : 5567-5580. doi: 10.3934/cpaa.2020251

[3]

Yu Zhou, Xinfeng Dong, Yongzhuang Wei, Fengrong Zhang. A note on the Signal-to-noise ratio of $ (n, m) $-functions. Advances in Mathematics of Communications, 2020  doi: 10.3934/amc.2020117

[4]

Jiahao Qiu, Jianjie Zhao. Maximal factors of order $ d $ of dynamical cubespaces. Discrete & Continuous Dynamical Systems - A, 2021, 41 (2) : 601-620. doi: 10.3934/dcds.2020278

[5]

Vieri Benci, Sunra Mosconi, Marco Squassina. Preface: Applications of mathematical analysis to problems in theoretical physics. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020446

[6]

Hai-Feng Huo, Shi-Ke Hu, Hong Xiang. Traveling wave solution for a diffusion SEIR epidemic model with self-protection and treatment. Electronic Research Archive, , () : -. doi: 10.3934/era.2020118

[7]

Yining Cao, Chuck Jia, Roger Temam, Joseph Tribbia. Mathematical analysis of a cloud resolving model including the ice microphysics. Discrete & Continuous Dynamical Systems - A, 2021, 41 (1) : 131-167. doi: 10.3934/dcds.2020219

[8]

Martin Kalousek, Joshua Kortum, Anja Schlömerkemper. Mathematical analysis of weak and strong solutions to an evolutionary model for magnetoviscoelasticity. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 17-39. doi: 10.3934/dcdss.2020331

[9]

Zongyuan Li, Weinan Wang. Norm inflation for the Boussinesq system. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020353

[10]

Neng Zhu, Zhengrong Liu, Fang Wang, Kun Zhao. Asymptotic dynamics of a system of conservation laws from chemotaxis. Discrete & Continuous Dynamical Systems - A, 2021, 41 (2) : 813-847. doi: 10.3934/dcds.2020301

[11]

Craig Cowan, Abdolrahman Razani. Singular solutions of a Lane-Emden system. Discrete & Continuous Dynamical Systems - A, 2021, 41 (2) : 621-656. doi: 10.3934/dcds.2020291

[12]

Abdelghafour Atlas, Mostafa Bendahmane, Fahd Karami, Driss Meskine, Omar Oubbih. A nonlinear fractional reaction-diffusion system applied to image denoising and decomposition. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020321

[13]

Manil T. Mohan. First order necessary conditions of optimality for the two dimensional tidal dynamics system. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020045

[14]

Sumit Arora, Manil T. Mohan, Jaydev Dabas. Approximate controllability of a Sobolev type impulsive functional evolution system in Banach spaces. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020049

[15]

Helmut Abels, Andreas Marquardt. On a linearized Mullins-Sekerka/Stokes system for two-phase flows. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020467

[16]

Adel M. Al-Mahdi, Mohammad M. Al-Gharabli, Salim A. Messaoudi. New general decay result for a system of viscoelastic wave equations with past history. Communications on Pure & Applied Analysis, 2021, 20 (1) : 389-404. doi: 10.3934/cpaa.2020273

[17]

Yuxin Zhang. The spatially heterogeneous diffusive rabies model and its shadow system. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020357

[18]

Hai Huang, Xianlong Fu. Optimal control problems for a neutral integro-differential system with infinite delay. Evolution Equations & Control Theory, 2020  doi: 10.3934/eect.2020107

[19]

Hao Wang. Uniform stability estimate for the Vlasov-Poisson-Boltzmann system. Discrete & Continuous Dynamical Systems - A, 2021, 41 (2) : 657-680. doi: 10.3934/dcds.2020292

[20]

Yichen Zhang, Meiqiang Feng. A coupled $ p $-Laplacian elliptic system: Existence, uniqueness and asymptotic behavior. Electronic Research Archive, 2020, 28 (4) : 1419-1438. doi: 10.3934/era.2020075

2018 Impact Factor: 1.313

Metrics

  • PDF downloads (23)
  • HTML views (0)
  • Cited by (5)

[Back to Top]