American Institute of Mathematical Sciences

Advanced
  • Previous Article
    New developments in using stochastic recipe for multi-compartment model: Inter-compartment traveling route, residence time, and exponential convolution expansion
  • MBE Home
  • This Issue
  • Next Article
    Feedback stabilization for a chemostat with delayed output
2009, 6(3): 649-661. doi: 10.3934/mbe.2009.6.649

A model for transmission of partial resistance to anti-malarial drugs

Hengki Tasman 1, , Edy Soewono 1, , Kuntjoro Adji Sidarto 1, , Din Syafruddin 2, and  William Oscar Rogers 3,

1. 

Industrial and Financial Mathematics Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132, Indonesia, Indonesia, Indonesia
2. 

Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta 10430, Indonesia
3. 

United States Naval Medical Research Unit 2, Jl. Percetakan Negara 29, Jakarta 10560, Indonesia

Received  November 2008 Revised  February 2009 Published  June 2009

Anti-malarial drug resistance has been identified in many regions for a long time. In this paper we formulate a mathematical model of the spread of anti-malarial drug resistance in the population. The model is suitable for malarial situations in developing countries. We consider the sensitive and resistant strains of malaria. There are two basic reproduction ratios corresponding to the strains. If the ratios corresponding to the infections of the sensitive and resistant strains are not equal and they are greater than one, then there exist two endemic non-coexistent equilibria. In the case where the two ratios are equal and they are greater than one, the coexistence of the sensitive and resistant strains exist in the population. It is shown here that the recovery rates of the infected host and the proportion of anti-malarial drug treatment play important roles in the spread of anti-malarial drug resistance. The interesting phenomena of ''long-time" coexistence, which may explain the real situation in the field, could occur for long period of time when those parameters satisfy certain conditions. In regards to control strategy in the field, these results could give a good understanding of means of slowing down the spread of anti-malarial drug resistance.
Keywords: dynamical system., basic reproduction ratio, anti-malarial drug resistance, mathematical epidemiology, treatment proportion.
Mathematics Subject Classification: 92D3.
Citation: Hengki Tasman, Edy Soewono, Kuntjoro Adji Sidarto, Din Syafruddin, William Oscar Rogers. A model for transmission of partial resistance to anti-malarial drugs. Mathematical Biosciences & Engineering, 2009, 6 (3) : 649-661. doi: 10.3934/mbe.2009.6.649
[1]

Ami B. Shah, Katarzyna A. Rejniak, Jana L. Gevertz. Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases. Mathematical Biosciences & Engineering, 2016, 13 (6) : 1185-1206. doi: 10.3934/mbe.2016038
[2]

Urszula Ledzewicz, Shuo Wang, Heinz Schättler, Nicolas André, Marie Amélie Heng, Eddy Pasquier. On drug resistance and metronomic chemotherapy: A mathematical modeling and optimal control approach. Mathematical Biosciences & Engineering, 2017, 14 (1) : 217-235. doi: 10.3934/mbe.2017014
[3]

Nicolas Bacaër, Cheikh Sokhna. A reaction-diffusion system modeling the spread of resistance to an antimalarial drug. Mathematical Biosciences & Engineering, 2005, 2 (2) : 227-238. doi: 10.3934/mbe.2005.2.227
[4]

Maciej Leszczyński, Urszula Ledzewicz, Heinz Schättler. Optimal control for a mathematical model for anti-angiogenic treatment with Michaelis-Menten pharmacodynamics. Discrete & Continuous Dynamical Systems - B, 2019, 24 (5) : 2315-2334. doi: 10.3934/dcdsb.2019097
[5]

Canan Çelik. Dynamical behavior of a ratio dependent predator-prey system with distributed delay. Discrete & Continuous Dynamical Systems - B, 2011, 16 (3) : 719-738. doi: 10.3934/dcdsb.2011.16.719
[6]

Zhenzhen Chen, Sze-Bi Hsu, Ya-Tang Yang. The continuous morbidostat: A chemostat with controlled drug application to select for drug resistance mutants. Communications on Pure & Applied Analysis, 2020, 19 (1) : 203-220. doi: 10.3934/cpaa.2020011
[7]

Urszula Ledzewicz, Heinz Schättler. Drug resistance in cancer chemotherapy as an optimal control problem. Discrete & Continuous Dynamical Systems - B, 2006, 6 (1) : 129-150. doi: 10.3934/dcdsb.2006.6.129
[8]

Cristian Tomasetti, Doron Levy. An elementary approach to modeling drug resistance in cancer. Mathematical Biosciences & Engineering, 2010, 7 (4) : 905-918. doi: 10.3934/mbe.2010.7.905
[9]

Avner Friedman, Najat Ziyadi, Khalid Boushaba. A model of drug resistance with infection by health care workers. Mathematical Biosciences & Engineering, 2010, 7 (4) : 779-792. doi: 10.3934/mbe.2010.7.779
[10]

Hui Cao, Yicang Zhou. The basic reproduction number of discrete SIR and SEIS models with periodic parameters. Discrete & Continuous Dynamical Systems - B, 2013, 18 (1) : 37-56. doi: 10.3934/dcdsb.2013.18.37
[11]

Tianhui Yang, Lei Zhang. Remarks on basic reproduction ratios for periodic abstract functional differential equations. Discrete & Continuous Dynamical Systems - B, 2019, 24 (12) : 6771-6782. doi: 10.3934/dcdsb.2019166
[12]

Elzbieta Ratajczyk, Urszula Ledzewicz, Maciej Leszczyński, Heinz Schättler. Treatment of glioma with virotherapy and TNF-α inhibitors: Analysis as a dynamical system. Discrete & Continuous Dynamical Systems - B, 2018, 23 (1) : 425-441. doi: 10.3934/dcdsb.2018029
[13]

Mostafa Fazly, Mahmoud Hesaaraki. Periodic solutions for a semi-ratio-dependent predator-prey dynamical system with a class of functional responses on time scales. Discrete & Continuous Dynamical Systems - B, 2008, 9 (2) : 267-279. doi: 10.3934/dcdsb.2008.9.267
[14]

Nicolas Bacaër, Xamxinur Abdurahman, Jianli Ye, Pierre Auger. On the basic reproduction number $R_0$ in sexual activity models for HIV/AIDS epidemics: Example from Yunnan, China. Mathematical Biosciences & Engineering, 2007, 4 (4) : 595-607. doi: 10.3934/mbe.2007.4.595
[15]

Leonid A. Bunimovich. Dynamical systems and operations research: A basic model. Discrete & Continuous Dynamical Systems - B, 2001, 1 (2) : 209-218. doi: 10.3934/dcdsb.2001.1.209
[16]

Svend Christensen, Preben Klarskov Hansen, Guozheng Qi, Jihuai Wang. The mathematical method of studying the reproduction structure of weeds and its application to Bromus sterilis. Discrete & Continuous Dynamical Systems - B, 2004, 4 (3) : 777-788. doi: 10.3934/dcdsb.2004.4.777
[17]

Radosław Kurek, Paweł Lubowiecki, Henryk Żołądek. The Hess-Appelrot system. Ⅲ. Splitting of separatrices and chaos. Discrete & Continuous Dynamical Systems - A, 2018, 38 (4) : 1955-1981. doi: 10.3934/dcds.2018079
[18]

Brandy Rapatski, Petra Klepac, Stephen Dueck, Maoxing Liu, Leda Ivic Weiss. Mathematical epidemiology of HIV/AIDS in cuba during the period 1986-2000. Mathematical Biosciences & Engineering, 2006, 3 (3) : 545-556. doi: 10.3934/mbe.2006.3.545
[19]

Gerardo Chowell, R. Fuentes, A. Olea, X. Aguilera, H. Nesse, J. M. Hyman. The basic reproduction number $R_0$ and effectiveness of reactive interventions during dengue epidemics: The 2002 dengue outbreak in Easter Island, Chile. Mathematical Biosciences & Engineering, 2013, 10 (5&6) : 1455-1474. doi: 10.3934/mbe.2013.10.1455
[20]

Elena Fimmel, Yury S. Semenov, Alexander S. Bratus. On optimal and suboptimal treatment strategies for a mathematical model of leukemia. Mathematical Biosciences & Engineering, 2013, 10 (1) : 151-165. doi: 10.3934/mbe.2013.10.151

2018 Impact Factor: 1.313

Tools

Metrics

  • PDF downloads (13)
  • HTML views (0)
  • Cited by (0)

Other articles
by authors

[Back to Top]

Copyright © 2020 American Institute of Mathematical Sciences