# American Institute of Mathematical Sciences

2010, 7(2): 401-419. doi: 10.3934/mbe.2010.7.401

## Characterization of the dynamic behavior of nonlinear biosystems in the presence of model uncertainty using singular invariance PDEs: Application to immobilized enzyme and cell bioreactors

 1 Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609-2280, United States 2 Department of Project Management, Technological Educational Institute (TEI) of Larissa, Larissa - 41110, Greece

Received  January 2009 Revised  August 2009 Published  April 2010

A new approach to the problem of characterizing the dynamic behavior of nonlinear biosystems in the presence of model uncertainty using the notion of slow invariant manifold is proposed. The problem of interest is addressed within the context of singular partial differential equations (PDE) theory, and in particular, through a system of singular quasi-linear invariance PDEs for which a general set of conditions for solvability is provided. Within the class of analytic solutions, this set of conditions guarantees the existence and uniqueness of a locally analytic solution which represents the system's slow invariant manifold exponentially attracting all dynamic trajectories in the absence of model uncertainty. An exact reduced-order model is then obtained through the restriction of the original biosystem dynamics on the slow manifold. The analyticity property of the solution to the invariance PDEs enables the development of a series solution method that can be easily implemented using MAPLE leading to polynomial approximations up to the desired degree of accuracy. Furthermore, the aforementioned attractivity property and the transition towards the above manifold is analyzed and characterized in the presence of model uncertainty. Finally, examples of certain immobilized enzyme bioreactors are considered to elucidate aspects of the proposed context of analysis.
Citation: Nikolaos Kazantzis, Vasiliki Kazantzi. Characterization of the dynamic behavior of nonlinear biosystems in the presence of model uncertainty using singular invariance PDEs: Application to immobilized enzyme and cell bioreactors. Mathematical Biosciences & Engineering, 2010, 7 (2) : 401-419. doi: 10.3934/mbe.2010.7.401
 [1] Alexander Komech. Attractors of Hamilton nonlinear PDEs. Discrete & Continuous Dynamical Systems - A, 2016, 36 (11) : 6201-6256. doi: 10.3934/dcds.2016071 [2] D.J. Georgiev, A. J. Roberts, D. V. Strunin. Nonlinear dynamics on centre manifolds describing turbulent floods: k-$\omega$ model. Conference Publications, 2007, 2007 (Special) : 419-428. doi: 10.3934/proc.2007.2007.419 [3] Nikolaos S. Papageorgiou, Vicenţiu D. Rădulescu, Dušan D. Repovš. Perturbations of nonlinear eigenvalue problems. Communications on Pure & Applied Analysis, 2019, 18 (3) : 1403-1431. doi: 10.3934/cpaa.2019068 [4] Marianne Beringhier, Adrien Leygue, Francisco Chinesta. Parametric nonlinear PDEs with multiple solutions: A PGD approach. Discrete & Continuous Dynamical Systems - S, 2016, 9 (2) : 383-392. doi: 10.3934/dcdss.2016002 [5] Gábor Székelyhidi, Ben Weinkove. On a constant rank theorem for nonlinear elliptic PDEs. Discrete & Continuous Dynamical Systems - A, 2016, 36 (11) : 6523-6532. doi: 10.3934/dcds.2016081 [6] Swann Marx, Tillmann Weisser, Didier Henrion, Jean Bernard Lasserre. A moment approach for entropy solutions to nonlinear hyperbolic PDEs. Mathematical Control & Related Fields, 2019, 0 (0) : 0-0. doi: 10.3934/mcrf.2019032 [7] P. De Maesschalck, Freddy Dumortier. Detectable canard cycles with singular slow dynamics of any order at the turning point. Discrete & Continuous Dynamical Systems - A, 2011, 29 (1) : 109-140. doi: 10.3934/dcds.2011.29.109 [8] H.Thomas Banks, Shuhua Hu. Nonlinear stochastic Markov processes and modeling uncertainty in populations. Mathematical Biosciences & Engineering, 2012, 9 (1) : 1-25. doi: 10.3934/mbe.2012.9.1 [9] Jianquan Li, Yicang Zhou, Jianhong Wu, Zhien Ma. Complex dynamics of a simple epidemic model with a nonlinear incidence. Discrete & Continuous Dynamical Systems - B, 2007, 8 (1) : 161-173. doi: 10.3934/dcdsb.2007.8.161 [10] Yuri Latushkin, Jan Prüss, Ronald Schnaubelt. Center manifolds and dynamics near equilibria of quasilinear parabolic systems with fully nonlinear boundary conditions. Discrete & Continuous Dynamical Systems - B, 2008, 9 (3&4, May) : 595-633. doi: 10.3934/dcdsb.2008.9.595 [11] Lorena Bociu, Barbara Kaltenbacher, Petronela Radu. Preface: Introduction to the Special Volume on Nonlinear PDEs and Control Theory with Applications. Evolution Equations & Control Theory, 2013, 2 (2) : i-ii. doi: 10.3934/eect.2013.2.2i [12] Risei Kano, Yusuke Murase. Solvability of nonlinear evolution equations generated by subdifferentials and perturbations. Discrete & Continuous Dynamical Systems - S, 2014, 7 (1) : 75-93. doi: 10.3934/dcdss.2014.7.75 [13] Liping Wang, Chunyi Zhao. Infinitely many solutions for nonlinear Schrödinger equations with slow decaying of potential. Discrete & Continuous Dynamical Systems - A, 2017, 37 (3) : 1707-1731. doi: 10.3934/dcds.2017071 [14] Tatiana Filippova. Differential equations of ellipsoidal state estimates in nonlinear control problems under uncertainty. Conference Publications, 2011, 2011 (Special) : 410-419. doi: 10.3934/proc.2011.2011.410 [15] Paulo Cesar Carrião, R. Demarque, Olímpio H. Miyagaki. Nonlinear Biharmonic Problems with Singular Potentials. Communications on Pure & Applied Analysis, 2014, 13 (6) : 2141-2154. doi: 10.3934/cpaa.2014.13.2141 [16] Suqi Ma, Qishao Lu, Shuli Mei. Dynamics of a logistic population model with maturation delay and nonlinear birth rate. Discrete & Continuous Dynamical Systems - B, 2005, 5 (3) : 735-752. doi: 10.3934/dcdsb.2005.5.735 [17] Youshan Tao. Global dynamics in a higher-dimensional repulsion chemotaxis model with nonlinear sensitivity. Discrete & Continuous Dynamical Systems - B, 2013, 18 (10) : 2705-2722. doi: 10.3934/dcdsb.2013.18.2705 [18] Conrad Bertrand Tabi, Alidou Mohamadou, Timoleon Crepin Kofane. Soliton-like excitation in a nonlinear model of DNA dynamics with viscosity. Mathematical Biosciences & Engineering, 2008, 5 (1) : 205-216. doi: 10.3934/mbe.2008.5.205 [19] Andrey V. Kremnev, Alexander S. Kuleshov. Nonlinear dynamics and stability of the skateboard. Discrete & Continuous Dynamical Systems - S, 2010, 3 (1) : 85-103. doi: 10.3934/dcdss.2010.3.85 [20] Ioannis Markou. Collision-avoiding in the singular Cucker-Smale model with nonlinear velocity couplings. Discrete & Continuous Dynamical Systems - A, 2018, 38 (10) : 5245-5260. doi: 10.3934/dcds.2018232

2018 Impact Factor: 1.313