American Institute of Mathematical Sciences

Advanced
2010, 7(2): 401-419. doi: 10.3934/mbe.2010.7.401

Characterization of the dynamic behavior of nonlinear biosystems in the presence of model uncertainty using singular invariance PDEs: Application to immobilized enzyme and cell bioreactors

Nikolaos Kazantzis 1, and  Vasiliki Kazantzi 2,

1. 

Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609-2280, United States
2. 

Department of Project Management, Technological Educational Institute (TEI) of Larissa, Larissa - 41110, Greece

Received  January 2009 Revised  August 2009 Published  April 2010

A new approach to the problem of characterizing the dynamic behavior of nonlinear biosystems in the presence of model uncertainty using the notion of slow invariant manifold is proposed. The problem of interest is addressed within the context of singular partial differential equations (PDE) theory, and in particular, through a system of singular quasi-linear invariance PDEs for which a general set of conditions for solvability is provided. Within the class of analytic solutions, this set of conditions guarantees the existence and uniqueness of a locally analytic solution which represents the system's slow invariant manifold exponentially attracting all dynamic trajectories in the absence of model uncertainty. An exact reduced-order model is then obtained through the restriction of the original biosystem dynamics on the slow manifold. The analyticity property of the solution to the invariance PDEs enables the development of a series solution method that can be easily implemented using MAPLE leading to polynomial approximations up to the desired degree of accuracy. Furthermore, the aforementioned attractivity property and the transition towards the above manifold is analyzed and characterized in the presence of model uncertainty. Finally, examples of certain immobilized enzyme bioreactors are considered to elucidate aspects of the proposed context of analysis.
Keywords: Nonlinear biosystems; Nonlinear dynamics; Slow manifolds; Singular PDEs; Immobilized enzyme bioreactors; Model uncertainty; Perturbations..
Mathematics Subject Classification: 34A34, 34C40, 34C45, 34D10, 35A20, 35C10, 37N25, 92B0.
Citation: Nikolaos Kazantzis, Vasiliki Kazantzi. Characterization of the dynamic behavior of nonlinear biosystems in the presence of model uncertainty using singular invariance PDEs: Application to immobilized enzyme and cell bioreactors. Mathematical Biosciences & Engineering, 2010, 7 (2) : 401-419. doi: 10.3934/mbe.2010.7.401
[1]

Maoding Zhen, Binlin Zhang, Vicenţiu D. Rădulescu. Normalized solutions for nonlinear coupled fractional systems: Low and high perturbations in the attractive case. Discrete & Continuous Dynamical Systems - A, 2020  doi: 10.3934/dcds.2020379
[2]

Eduard Feireisl, Elisabetta Rocca, Giulio Schimperna, Arghir Zarnescu. Weak sequential stability for a nonlinear model of nematic electrolytes. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 219-241. doi: 10.3934/dcdss.2020366
[3]

José Luis López. A quantum approach to Keller-Segel dynamics via a dissipative nonlinear Schrödinger equation. Discrete & Continuous Dynamical Systems - A, 2020  doi: 10.3934/dcds.2020376
[4]

Mokhtar Bouloudene, Manar A. Alqudah, Fahd Jarad, Yassine Adjabi, Thabet Abdeljawad. Nonlinear singular $ p $ -Laplacian boundary value problems in the frame of conformable derivative. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020442
[5]

Omid Nikan, Seyedeh Mahboubeh Molavi-Arabshai, Hossein Jafari. Numerical simulation of the nonlinear fractional regularized long-wave model arising in ion acoustic plasma waves. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020466
[6]

Weiwei Liu, Jinliang Wang, Yuming Chen. Threshold dynamics of a delayed nonlocal reaction-diffusion cholera model. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020316
[7]

Cuicui Li, Lin Zhou, Zhidong Teng, Buyu Wen. The threshold dynamics of a discrete-time echinococcosis transmission model. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020339
[8]

Gunther Uhlmann, Jian Zhai. Inverse problems for nonlinear hyperbolic equations. Discrete & Continuous Dynamical Systems - A, 2021, 41 (1) : 455-469. doi: 10.3934/dcds.2020380
[9]

Predrag S. Stanimirović, Branislav Ivanov, Haifeng Ma, Dijana Mosić. A survey of gradient methods for solving nonlinear optimization. Electronic Research Archive, 2020, 28 (4) : 1573-1624. doi: 10.3934/era.2020115
[10]

Thomas Bartsch, Tian Xu. Strongly localized semiclassical states for nonlinear Dirac equations. Discrete & Continuous Dynamical Systems - A, 2021, 41 (1) : 29-60. doi: 10.3934/dcds.2020297
[11]

Hua Chen, Yawei Wei. Multiple solutions for nonlinear cone degenerate elliptic equations. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2020272
[12]

D. R. Michiel Renger, Johannes Zimmer. Orthogonality of fluxes in general nonlinear reaction networks. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 205-217. doi: 10.3934/dcdss.2020346
[13]

A. M. Elaiw, N. H. AlShamrani, A. Abdel-Aty, H. Dutta. Stability analysis of a general HIV dynamics model with multi-stages of infected cells and two routes of infection. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020441
[14]

Nguyen Thi Kim Son, Nguyen Phuong Dong, Le Hoang Son, Alireza Khastan, Hoang Viet Long. Complete controllability for a class of fractional evolution equations with uncertainty. Evolution Equations & Control Theory, 2020  doi: 10.3934/eect.2020104
[15]

Abdelghafour Atlas, Mostafa Bendahmane, Fahd Karami, Driss Meskine, Omar Oubbih. A nonlinear fractional reaction-diffusion system applied to image denoising and decomposition. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020321
[16]

Xuefei He, Kun Wang, Liwei Xu. Efficient finite difference methods for the nonlinear Helmholtz equation in Kerr medium. Electronic Research Archive, 2020, 28 (4) : 1503-1528. doi: 10.3934/era.2020079
[17]

Thierry Cazenave, Ivan Naumkin. Local smooth solutions of the nonlinear Klein-gordon equation. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020448
[18]

Zhiyan Ding, Qin Li, Jianfeng Lu. Ensemble Kalman Inversion for nonlinear problems: Weights, consistency, and variance bounds. Foundations of Data Science, 2020  doi: 10.3934/fods.2020018
[19]

Yuxia Guo, Shaolong Peng. A direct method of moving planes for fully nonlinear nonlocal operators and applications. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020462
[20]

Scipio Cuccagna, Masaya Maeda. A survey on asymptotic stability of ground states of nonlinear Schrödinger equations II. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020450

2018 Impact Factor: 1.313

Tools

Metrics

  • PDF downloads (17)
  • HTML views (0)
  • Cited by (1)

Other articles
by authors

[Back to Top]

Copyright © 2020 American Institute of Mathematical Sciences