American Institute of Mathematical Sciences

Advanced
2010, 7(3): 505-526. doi: 10.3934/mbe.2010.7.505

A method for analyzing the stability of the resting state for a model of pacemaker cells surrounded by stable cells

Robert Artebrant 1, , Aslak Tveito 2, and  Glenn T. Lines 2,

1. 

Simula Research Laboratory, P.O. Box 134, 1325 Lysaker, Norway
2. 

Simula Research Laboratory, Center for Biomedical Computing, and Department of Informatics at the University of Oslo, P.O. Box 134, 1325 Lysaker, Norway, Norway

Received  April 2009 Revised  October 2009 Published  June 2010

The purpose of this paper is to derive and analyze methods for examining the stability of solutions of partial differential equations modeling collections of excitable cells. In particular, we derive methods for estimating the principal eigenvalue of a linearized version of the Luo-Rudy I model close to an equilibrium solution. It has been suggested that the stability of a collection of unstable cells surrounded by a large collection of stable cells can be studied by considering only a collection of unstable cells equipped with a Dirichlet type boundary condition. This method has earlier been applied to analytically assess the stability of a reduced version the Luo-Rudy I model. In this paper we analyze the accuracy of this technique and apply it to the full Luo-Rudy I model. Furthermore, we extend the method to provide analytical results for the FitzHugh-Nagumo model in the case where a collection of unstable cells is surrounded by a collection of stable cells. All our analytical findings are complemented by numerical computations computing the principal eigenvalue of a discrete version of linearized models.
Keywords: Ectopic waves, Partial differential equations, Stability..
Mathematics Subject Classification: 92B05, 35R0.
Citation: Robert Artebrant, Aslak Tveito, Glenn T. Lines. A method for analyzing the stability of the resting state for a model of pacemaker cells surrounded by stable cells. Mathematical Biosciences & Engineering, 2010, 7 (3) : 505-526. doi: 10.3934/mbe.2010.7.505
[1]

Tomás Caraballo, José Real, T. Taniguchi. The exponential stability of neutral stochastic delay partial differential equations. Discrete & Continuous Dynamical Systems - A, 2007, 18 (2&3) : 295-313. doi: 10.3934/dcds.2007.18.295
[2]

Abdelhai Elazzouzi, Aziz Ouhinou. Optimal regularity and stability analysis in the $\alpha-$Norm for a class of partial functional differential equations with infinite delay. Discrete & Continuous Dynamical Systems - A, 2011, 30 (1) : 115-135. doi: 10.3934/dcds.2011.30.115
[3]

Herbert Koch. Partial differential equations with non-Euclidean geometries. Discrete & Continuous Dynamical Systems - S, 2008, 1 (3) : 481-504. doi: 10.3934/dcdss.2008.1.481
[4]

Wilhelm Schlag. Spectral theory and nonlinear partial differential equations: A survey. Discrete & Continuous Dynamical Systems - A, 2006, 15 (3) : 703-723. doi: 10.3934/dcds.2006.15.703
[5]

Eugenia N. Petropoulou, Panayiotis D. Siafarikas. Polynomial solutions of linear partial differential equations. Communications on Pure & Applied Analysis, 2009, 8 (3) : 1053-1065. doi: 10.3934/cpaa.2009.8.1053
[6]

Arnulf Jentzen. Taylor expansions of solutions of stochastic partial differential equations. Discrete & Continuous Dynamical Systems - B, 2010, 14 (2) : 515-557. doi: 10.3934/dcdsb.2010.14.515
[7]

Nguyen Thieu Huy, Ngo Quy Dang. Dichotomy and periodic solutions to partial functional differential equations. Discrete & Continuous Dynamical Systems - B, 2017, 22 (8) : 3127-3144. doi: 10.3934/dcdsb.2017167
[8]

Barbara Abraham-Shrauner. Exact solutions of nonlinear partial differential equations. Discrete & Continuous Dynamical Systems - S, 2018, 11 (4) : 577-582. doi: 10.3934/dcdss.2018032
[9]

Paul Bracken. Exterior differential systems and prolongations for three important nonlinear partial differential equations. Communications on Pure & Applied Analysis, 2011, 10 (5) : 1345-1360. doi: 10.3934/cpaa.2011.10.1345
[10]

Masahito Ohta. Strong instability of standing waves for nonlinear Schrödinger equations with a partial confinement. Communications on Pure & Applied Analysis, 2018, 17 (4) : 1671-1680. doi: 10.3934/cpaa.2018080
[11]

Lili Fan, Hongxia Liu, Huijiang Zhao, Qingyang Zou. Global stability of stationary waves for damped wave equations. Kinetic & Related Models, 2013, 6 (4) : 729-760. doi: 10.3934/krm.2013.6.729
[12]

Frédéric Mazenc, Christophe Prieur. Strict Lyapunov functions for semilinear parabolic partial differential equations. Mathematical Control & Related Fields, 2011, 1 (2) : 231-250. doi: 10.3934/mcrf.2011.1.231
[13]

Enrique Zuazua. Controllability of partial differential equations and its semi-discrete approximations. Discrete & Continuous Dynamical Systems - A, 2002, 8 (2) : 469-513. doi: 10.3934/dcds.2002.8.469
[14]

Paul Bracken. Connections of zero curvature and applications to nonlinear partial differential equations. Discrete & Continuous Dynamical Systems - S, 2014, 7 (6) : 1165-1179. doi: 10.3934/dcdss.2014.7.1165
[15]

Michela Eleuteri, Pavel Krejčí. An asymptotic convergence result for a system of partial differential equations with hysteresis. Communications on Pure & Applied Analysis, 2007, 6 (4) : 1131-1143. doi: 10.3934/cpaa.2007.6.1131
[16]

Yuhki Hosoya. First-order partial differential equations and consumer theory. Discrete & Continuous Dynamical Systems - S, 2018, 11 (6) : 1143-1167. doi: 10.3934/dcdss.2018065
[17]

Hernán R. Henríquez, Claudio Cuevas, Alejandro Caicedo. Asymptotically periodic solutions of neutral partial differential equations with infinite delay. Communications on Pure & Applied Analysis, 2013, 12 (5) : 2031-2068. doi: 10.3934/cpaa.2013.12.2031
[18]

Frédéric Gibou, Doron Levy, Carlos Cárdenas, Pingyu Liu, Arthur Boyer. Partial Differential Equations-Based Segmentation for Radiotherapy Treatment Planning. Mathematical Biosciences & Engineering, 2005, 2 (2) : 209-226. doi: 10.3934/mbe.2005.2.209
[19]

Rongmei Cao, Jiangong You. The existence of integrable invariant manifolds of Hamiltonian partial differential equations. Discrete & Continuous Dynamical Systems - A, 2006, 16 (1) : 227-234. doi: 10.3934/dcds.2006.16.227
[20]

Seyedeh Marzieh Ghavidel, Wolfgang M. Ruess. Flow invariance for nonautonomous nonlinear partial differential delay equations. Communications on Pure & Applied Analysis, 2012, 11 (6) : 2351-2369. doi: 10.3934/cpaa.2012.11.2351

2018 Impact Factor: 1.313

Tools

Metrics

  • PDF downloads (15)
  • HTML views (0)
  • Cited by (0)

Other articles
by authors

[Back to Top]

Copyright © 2019 American Institute of Mathematical Sciences