Global stability of an HIV-1 model with distributed intracellular delays and a combination therapy

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2010, 7(3): 675-685. doi: 10.3934/mbe.2010.7.675

Global stability of an HIV-1 model with distributed intracellular delays and a combination therapy

1.	Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, 3041#, 2 Yi-Kuang Street, Harbin, 150080, China
2.	Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB, E3B 5A3, Canada

Received December 2009 Revised April 2010 Published June 2010

Abstract
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Global stability is analyzed for a general mathematical model of HIV-1 pathogenesis proposed by Nelson and Perelson [11]. The general model include two distributed intracellular delays and a combination therapy with a reverse transcriptase inhibitor and a protease inhibitor. It is shown that the model exhibits a threshold dynamics: if the basic reproduction number is less than or equal to one, then the HIV-1 infection is cleared from the T-cell population; whereas if the basic reproduction number is larger than one, then the HIV-1 infection persists and the viral concentration maintains at a constant level.

Keywords: HIV-1; Global stability; delay; steady state; Lyapunov functional..

Mathematics Subject Classification: 34K20, 92D3.

Citation: Shengqiang Liu, Lin Wang. Global stability of an HIV-1 model with distributed intracellular delays and a combination therapy. Mathematical Biosciences & Engineering, 2010, 7 (3) : 675-685. doi: 10.3934/mbe.2010.7.675

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