Rotating antibiotics does not minimize selection for resistance

Sebastian Bonhoeffer; Pia Abel zur Wiesch; Roger D. Kouyos

doi:10.3934/mbe.2010.7.919

Article Contents

2010, Volume 7, Issue 4: 919-922. Doi: 10.3934/mbe.2010.7.919

This issue Previous Article An elementary approach to modeling drug resistance in cancer Next Article Antibiotic cycling versus mixing: The difficulty of using mathematical models to definitively quantify their relative merits

Rotating antibiotics does not minimize selection for resistance

1.
Institute of Integrative Biology, ETH Zürich, CH-8092 Zurich

Received: July 31, 2010

Revised: August 31, 2010

Published: September 2010

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Mathematics Subject Classification: 92B05, 92C50, 92D30, 93C15.

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References

[1]	R. Beardmore and R. Peñal-Miller, Rotating antibiotics selects optimally against antibiotic resistance, Mathematical Biosciences and Engineering, 7 (2010), 527-552.doi: doi:10.3934/mbe.2010.7.527.
[2]	S. Bonhoeffer, M. Lipsitch and B. R. Levin, Evaluating treatment protocols to prevent antibiotic resistance, PNAS, 94 (1997), 12106-12111.doi: doi:10.1073/pnas.94.22.12106.
[3]	C. T. Bergstrom, M. Lo and M. Lipsitch, Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals, PNAS, 101 (2004), 13285-13290.doi: doi:10.1073/pnas.0402298101.