# American Institute of Mathematical Sciences

2012, 9(4): 899-914. doi: 10.3934/mbe.2012.9.899

## Hybrid optimal control for HIV multi-drug therapies: A finite set control transcription approach

 1 Department of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX 78712, United States 2 School of Aeronautics and Astronautics, Purdue University, West Lafayette, IN 47907, United States

Received  August 2011 Revised  March 2012 Published  October 2012

In this study, the treatment of Human Immunodeficiency Virus (HIV) infection is investigated through an optimal structured treatment interruption (STI) schedule of two classes of antiretroviral drugs, mainly, reverse transcriptase inhibitors and protease inhibitors. An STI treatment strategy may be beneficial in lowering the risk of HIV mutating to drug-resistant strains, and could provide patients with respite from toxic side effects of HAART. A shorter treatment period is considered compared to previous studies and the solution to the HIV STI problem is obtained via the Finite Set Control Transcription (FSCT) formulation. The FSCT formulation offers a unique approach for handling multiple independent decision variables simultaneously, and, as is shown by the results of this study, is well-suited for an effective treatment of the optimal STI problem. The results obtained in the present investigation demonstrate that immune boosting and subsequent natural suppression of the viral load are possible even when a reduced STI therapy treatment duration is in consideration.
Citation: Divya Thakur, Belinda Marchand. Hybrid optimal control for HIV multi-drug therapies: A finite set control transcription approach. Mathematical Biosciences & Engineering, 2012, 9 (4) : 899-914. doi: 10.3934/mbe.2012.9.899
##### References:

show all references

##### References:
 [1] Hui Lv, Xing'an Wang. Dissipative control for uncertain singular markovian jump systems via hybrid impulsive control. Numerical Algebra, Control & Optimization, 2021, 11 (1) : 127-142. doi: 10.3934/naco.2020020 [2] Hong Niu, Zhijiang Feng, Qijin Xiao, Yajun Zhang. A PID control method based on optimal control strategy. Numerical Algebra, Control & Optimization, 2021, 11 (1) : 117-126. doi: 10.3934/naco.2020019 [3] Lars Grüne, Matthias A. Müller, Christopher M. Kellett, Steven R. Weller. Strict dissipativity for discrete time discounted optimal control problems. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020046 [4] Hai Huang, Xianlong Fu. Optimal control problems for a neutral integro-differential system with infinite delay. Evolution Equations & Control Theory, 2020  doi: 10.3934/eect.2020107 [5] Youming Guo, Tingting Li. Optimal control strategies for an online game addiction model with low and high risk exposure. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020347 [6] Pierluigi Colli, Gianni Gilardi, Jürgen Sprekels. Deep quench approximation and optimal control of general Cahn–Hilliard systems with fractional operators and double obstacle potentials. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 243-271. doi: 10.3934/dcdss.2020213 [7] Stefan Doboszczak, Manil T. Mohan, Sivaguru S. Sritharan. Pontryagin maximum principle for the optimal control of linearized compressible navier-stokes equations with state constraints. Evolution Equations & Control Theory, 2020  doi: 10.3934/eect.2020110 [8] Bernard Bonnard, Jérémy Rouot. Geometric optimal techniques to control the muscular force response to functional electrical stimulation using a non-isometric force-fatigue model. Journal of Geometric Mechanics, 2020  doi: 10.3934/jgm.2020032 [9] Zuliang Lu, Fei Huang, Xiankui Wu, Lin Li, Shang Liu. Convergence and quasi-optimality of $L^2-$norms based an adaptive finite element method for nonlinear optimal control problems. Electronic Research Archive, 2020, 28 (4) : 1459-1486. doi: 10.3934/era.2020077 [10] Adam Glick, Antonio Mastroberardino. Combined therapy for treating solid tumors with chemotherapy and angiogenic inhibitors. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020343 [11] Hai-Feng Huo, Shi-Ke Hu, Hong Xiang. Traveling wave solution for a diffusion SEIR epidemic model with self-protection and treatment. Electronic Research Archive, , () : -. doi: 10.3934/era.2020118 [12] José Madrid, João P. G. Ramos. On optimal autocorrelation inequalities on the real line. Communications on Pure & Applied Analysis, 2021, 20 (1) : 369-388. doi: 10.3934/cpaa.2020271 [13] Sergio Conti, Georg Dolzmann. Optimal laminates in single-slip elastoplasticity. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 1-16. doi: 10.3934/dcdss.2020302 [14] Haili Yuan, Yijun Hu. Optimal investment for an insurer under liquid reserves. Journal of Industrial & Management Optimization, 2021, 17 (1) : 339-355. doi: 10.3934/jimo.2019114 [15] Awais Younus, Zoubia Dastgeer, Nudrat Ishaq, Abdul Ghaffar, Kottakkaran Sooppy Nisar, Devendra Kumar. On the observability of conformable linear time-invariant control systems. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020444 [16] Yuan Tan, Qingyuan Cao, Lan Li, Tianshi Hu, Min Su. A chance-constrained stochastic model predictive control problem with disturbance feedback. Journal of Industrial & Management Optimization, 2021, 17 (1) : 67-79. doi: 10.3934/jimo.2019099 [17] Tommi Brander, Joonas Ilmavirta, Petteri Piiroinen, Teemu Tyni. Optimal recovery of a radiating source with multiple frequencies along one line. Inverse Problems & Imaging, 2020, 14 (6) : 967-983. doi: 10.3934/ipi.2020044 [18] Veena Goswami, Gopinath Panda. Optimal customer behavior in observable and unobservable discrete-time queues. Journal of Industrial & Management Optimization, 2021, 17 (1) : 299-316. doi: 10.3934/jimo.2019112 [19] M. S. Lee, H. G. Harno, B. S. Goh, K. H. Lim. On the bang-bang control approach via a component-wise line search strategy for unconstrained optimization. Numerical Algebra, Control & Optimization, 2021, 11 (1) : 45-61. doi: 10.3934/naco.2020014 [20] Xuefeng Zhang, Yingbo Zhang. Fault-tolerant control against actuator failures for uncertain singular fractional order systems. Numerical Algebra, Control & Optimization, 2021, 11 (1) : 1-12. doi: 10.3934/naco.2020011

2018 Impact Factor: 1.313