Article Contents
Article Contents

# On the return process with refractoriness for a non-homogeneous Ornstein-Uhlenbeck neuronal model

• An Ornstein-Uhlenbeck diffusion process is considered as a model for the membrane potential activity of a single neuron. We assume that the neuron is subject to a sequence of inhibitory and excitatory post-synaptic potentials that occur with time-dependent rates. The resulting process is characterized by time-dependent drift. For this model, we construct the return process describing the membrane potential. It is a non homogeneous Ornstein-Uhlenbeck process with jumps on which the effect of random refractoriness is introduced. An asymptotic analysis of the process modeling the number of firings and the distribution of interspike intervals is performed under the assumption of exponential distribution for the firing time. Some numerical evaluations are performed to provide quantitative information on the role of the parameters.
Mathematics Subject Classification: Primary: 60J60, 92C20; Secondary: 60J75.

 Citation:

•  [1] A. Buonocore, A. G. Nobile and L. M. Ricciardi, A new integral equation for the evaluation of first-passage-time probability densities, Adv. Appl. Prob., 19 (1987), 784-800.doi: 10.2307/1427102. [2] A. Buonocore, L. Caputo and E. Pirozzi, On the evaluation of firing densities for periodically driven neuron models, Math. Biosci., 214 (2008), 122-133.doi: 10.1016/j.mbs.2008.02.003. [3] R. M. Capocelli and L. M. Ricciardi, Diffusion approximation and first passage time problem for a model neuron, Kybernetik (Berlin), 8 (1971), 214-223.doi: 10.1007/BF00288750. [4] S. Ditlevsen and P. Lansky, Estimation of the input parameters in the Ornstein-Uhlenbeck neuronal model, Phys. Rev. E (3), 71 (2005), 011907, 9 pp.doi: 10.1103/PhysRevE.71.011907. [5] S. Ditlevsen and P. Lansky, Comparison of statistical methods for estimation of the input parameters in the Ornstein-Uhlenbeck neuronal model from first-passage times data, in Collective Dynamics: Topics on Competition and Cooperation in the Biosciences (eds. L. M. Ricciardi, A. Buonocore and E. Pirozzi), AIP Conf. Proc., 1028, Amer. Inst. Phys., Melville, NY, 2008, 171-185.doi: 10.1063/1.2965085. [6] G, Esposito, V. Giorno, A. G. Nobile, L. M. Ricciardi and C. Valerio, Neuronal modeling in the presence of random refractoriness, Sci. Math. Jpn., 64 (2006), 1-36. [7] G. L. Gerstein and B. Mandelbrot, Random walk models for the spike activity of a single neuron, Biophys. J., 4 (1964), 41-68.doi: 10.1016/S0006-3495(64)86768-0. [8] V. Giorno, A. G. Nobile and L. M. Ricciardi, On the asymptotic behaviour of first-passage-time densities for one-dimensional diffusion processes and varying boundaries, Adv. in Appl. Probab., 22 (1990), 883-914.doi: 10.2307/1427567. [9] M. T. Giraudo and L. Sacerdote, Jump-diffusion processes as models for neuronal activity, BioSystems, 40 (1997), 75-82.doi: 10.1016/0303-2647(96)01632-2. [10] P. Lansky and L. Sacerdote, The Ornstein-Uhlenbeck neuronal model with signal-dependent noise, Physics Letters A, 285 (2001), 132-140.doi: 10.1016/S0375-9601(01)00340-1. [11] P. Lansky, P. Sanda and J. He, The parameters of the stochastic leaky integrate-and-fire neuronal model, J. Comput. Neurosci., 21 (2006), 211-223.doi: 10.1007/s10827-006-8527-6. [12] L. M. Ricciardi and F. Esposito, On some distribution functions for non-linear switching elements with finite dead time, Kybernetik, 3 (1966), 148-152.doi: 10.1007/BF00288925. [13] L. M. Ricciardi, A. Di Crescenzo, V. Giorno and A. G. Nobile, An outline of theoretical and algorithmic approaches to first passage time problems with applications to biological modeling, Math. Japon., 50 (1999), 247-322. [14] L. M. Ricciardi and L. Sacerdote, The Ornstein-Uhlenbeck process as a model for neuronal activity, Biol. Cyb., 35 (1979), 1-9.doi: 10.1007/BF01845839. [15] M. C. Teich, L. Matin and B. I. Cantor, Refractoriness in the maintained discharge of the cat's retinal ganglion cell, J. Opt. Soc. Am., 68 (1978), 386-402.doi: 10.1364/JOSA.68.000386.
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