On viable therapy strategy for a mathematical spatial cancer model describing the dynamics of malignant and healthy cells

Alexander S. Bratus; Svetlana Yu. Kovalenko; Elena Fimmel

doi:10.3934/mbe.2015.12.163

Article Contents

2015, Volume 12, Issue 1: 163-183. Doi: 10.3934/mbe.2015.12.163

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On viable therapy strategy for a mathematical spatial cancer model describing the dynamics of malignant and healthy cells

1.
Moscow State University, GSP-1, Leninskie Gory, Moscow
2.
Federal Science and Clinical Center of the Federal Medical and Biological Agency, 28 Orehovuy boulevard, Moscow, 115682
3.
Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim

Received: November 2013

Revised: October 2014

Published: December 2014

Abstract / Introduction Related Papers Cited by

Abstract

A mathematical spatial cancer model of the interaction between a drug and both malignant and healthy cells is considered. It is assumed that the drug influences negative malignant cells as well as healthy ones. The mathematical model considered consists of three nonlinear parabolic partial differential equations which describe spatial dynamics of malignant cells as well as healthy ones, and of the concentration of the drug. Additionally, we assume some phase constraints for the number of the malignant and the healthy cells and for the total dose of the drug during the whole treatment process.
We search through all the courses of treatment switching between an application of the drug with the maximum intensity (intensive therapy phase) and discontinuing administering of the drug (relaxation phase) with the objective of achieving the maximum possible therapy (survival) time. We will call the therapy a viable treatment strategy.

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Mathematics Subject Classification: 49J20.

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