# American Institute of Mathematical Sciences

2015, 12(5): 917-936. doi: 10.3934/mbe.2015.12.917

## Parameters identification for a model of T cell homeostasis

 1 IMB UMR CNRS 5251, Bordeaux University, 3 Place de la Victoire, 33076 Bordeaux Cedex, France, France, France 2 INSERM U897, ISPED, Bordeaux University, Bordeaux, France

Received  November 2014 Revised  April 2015 Published  June 2015

In this study, we consider a model of T cell homeostasis based on the Smith-Martin model. This nonlinear model is structured by age and CD44 expression. First, we establish the mathematical well-posedness of the model system. Next, we prove the theoretical identifiability regarding the up-regulation of CD44, the proliferation time phase and the rate of entry into division, by using the experimental data. Finally, we compare two versions of the Smith-Martin model and we identify which model fits the experimental data best.
Citation: Houssein Ayoub, Bedreddine Ainseba, Michel Langlais, Rodolphe Thiébaut. Parameters identification for a model of T cell homeostasis. Mathematical Biosciences & Engineering, 2015, 12 (5) : 917-936. doi: 10.3934/mbe.2015.12.917
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##### References:
 [1] Lorenzo Zambotti. A brief and personal history of stochastic partial differential equations. Discrete & Continuous Dynamical Systems - A, 2021, 41 (1) : 471-487. doi: 10.3934/dcds.2020264 [2] Yueyang Zheng, Jingtao Shi. A stackelberg game of backward stochastic differential equations with partial information. Mathematical Control & Related Fields, 2020  doi: 10.3934/mcrf.2020047 [3] Hua Qiu, Zheng-An Yao. The regularized Boussinesq equations with partial dissipations in dimension two. Electronic Research Archive, 2020, 28 (4) : 1375-1393. doi: 10.3934/era.2020073 [4] Yue-Jun Peng, Shu Wang. Asymptotic expansions in two-fluid compressible Euler-Maxwell equations with small parameters. Discrete & Continuous Dynamical Systems - A, 2009, 23 (1&2) : 415-433. doi: 10.3934/dcds.2009.23.415 [5] Michal Fečkan, Kui Liu, JinRong Wang. $(\omega,\mathbb{T})$-periodic solutions of impulsive evolution equations. Evolution Equations & Control Theory, 2021  doi: 10.3934/eect.2021006 [6] Fabio Camilli, Giulia Cavagnari, Raul De Maio, Benedetto Piccoli. Superposition principle and schemes for measure differential equations. Kinetic & Related Models, 2021, 14 (1) : 89-113. doi: 10.3934/krm.2020050 [7] Stefan Ruschel, Serhiy Yanchuk. The spectrum of delay differential equations with multiple hierarchical large delays. Discrete & Continuous Dynamical Systems - S, 2021, 14 (1) : 151-175. doi: 10.3934/dcdss.2020321 [8] John Mallet-Paret, Roger D. Nussbaum. Asymptotic homogenization for delay-differential equations and a question of analyticity. Discrete & Continuous Dynamical Systems - A, 2020, 40 (6) : 3789-3812. doi: 10.3934/dcds.2020044 [9] Mugen Huang, Moxun Tang, Jianshe Yu, Bo Zheng. A stage structured model of delay differential equations for Aedes mosquito population suppression. Discrete & Continuous Dynamical Systems - A, 2020, 40 (6) : 3467-3484. doi: 10.3934/dcds.2020042 [10] Bixiang Wang. Mean-square random invariant manifolds for stochastic differential equations. Discrete & Continuous Dynamical Systems - A, 2021, 41 (3) : 1449-1468. doi: 10.3934/dcds.2020324 [11] Rim Bourguiba, Rosana Rodríguez-López. Existence results for fractional differential equations in presence of upper and lower solutions. Discrete & Continuous Dynamical Systems - B, 2021, 26 (3) : 1723-1747. doi: 10.3934/dcdsb.2020180 [12] Ole Løseth Elvetun, Bjørn Fredrik Nielsen. A regularization operator for source identification for elliptic PDEs. Inverse Problems & Imaging, , () : -. doi: 10.3934/ipi.2021006 [13] Xianbo Sun, Zhanbo Chen, Pei Yu. Parameter identification on Abelian integrals to achieve Chebyshev property. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020375 [14] Sergio Zamora. Tori can't collapse to an interval. Electronic Research Archive, , () : -. doi: 10.3934/era.2021005 [15] Thabet Abdeljawad, Mohammad Esmael Samei. Applying quantum calculus for the existence of solution of $q$-integro-differential equations with three criteria. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020440 [16] Fathalla A. Rihan, Hebatallah J. Alsakaji. Stochastic delay differential equations of three-species prey-predator system with cooperation among prey species. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020468 [17] Guangjun Shen, Xueying Wu, Xiuwei Yin. Stabilization of stochastic differential equations driven by G-Lévy process with discrete-time feedback control. Discrete & Continuous Dynamical Systems - B, 2021, 26 (2) : 755-774. doi: 10.3934/dcdsb.2020133 [18] Tin Phan, Bruce Pell, Amy E. Kendig, Elizabeth T. Borer, Yang Kuang. Rich dynamics of a simple delay host-pathogen model of cell-to-cell infection for plant virus. Discrete & Continuous Dynamical Systems - B, 2021, 26 (1) : 515-539. doi: 10.3934/dcdsb.2020261 [19] Andy Hammerlindl, Jana Rodriguez Hertz, Raúl Ures. Ergodicity and partial hyperbolicity on Seifert manifolds. Journal of Modern Dynamics, 2020, 0: 331-348. doi: 10.3934/jmd.2020012 [20] Meilan Cai, Maoan Han. Limit cycle bifurcations in a class of piecewise smooth cubic systems with multiple parameters. Communications on Pure & Applied Analysis, 2021, 20 (1) : 55-75. doi: 10.3934/cpaa.2020257

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