# American Institute of Mathematical Sciences

• Previous Article
Successive spike times predicted by a stochastic neuronal model with a variable input signal
• MBE Home
• This Issue
• Next Article
The effect of positive interspike interval correlations on neuronal information transmission
2016, 13(3): 483-493. doi: 10.3934/mbe.2016002

## A leaky integrate-and-fire model with adaptation for the generation of a spike train

 1 Dipartimento di Matematica e Applicazioni “R. Caccioppoli”, Università di Napoli Federico II, Via Cintia, 80126 Napoli 2 Dipartimento di Matematica e Applicazioni, Università di Napoli Federico II, Via Cintia, Napoli 3 Istituto per le Appplicazioni del Calcolo "Mauro Picone", Consiglio Nazionale delle Ricerche, Via Pietro Castellino, Napoli

Received  April 2015 Revised  November 2015 Published  January 2016

A model is proposed to describe the spike-frequency adaptation observed in many neuronal systems. We assume that adaptation is mainly due to a calcium-activated potassium current, and we consider two coupled stochastic differential equations for which an analytical approach combined with simulation techniques and numerical methods allow to obtain both qualitative and quantitative results about asymptotic mean firing rate, mean calcium concentration and the firing probability density. A related algorithm, based on the Hazard Rate Method, is also devised and described.
Citation: Aniello Buonocore, Luigia Caputo, Enrica Pirozzi, Maria Francesca Carfora. A leaky integrate-and-fire model with adaptation for the generation of a spike train. Mathematical Biosciences & Engineering, 2016, 13 (3) : 483-493. doi: 10.3934/mbe.2016002
##### References:

show all references

##### References:
 [1] Dan Zhu, Rosemary A. Renaut, Hongwei Li, Tianyou Liu. Fast non-convex low-rank matrix decomposition for separation of potential field data using minimal memory. Inverse Problems & Imaging, , () : -. doi: 10.3934/ipi.2020076 [2] Min Chen, Olivier Goubet, Shenghao Li. Mathematical analysis of bump to bucket problem. Communications on Pure & Applied Analysis, 2020, 19 (12) : 5567-5580. doi: 10.3934/cpaa.2020251 [3] Qianqian Han, Xiao-Song Yang. Qualitative analysis of a generalized Nosé-Hoover oscillator. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020346 [4] Laurence Cherfils, Stefania Gatti, Alain Miranville, Rémy Guillevin. Analysis of a model for tumor growth and lactate exchanges in a glioma. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020457 [5] Vieri Benci, Sunra Mosconi, Marco Squassina. Preface: Applications of mathematical analysis to problems in theoretical physics. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020446 [6] Yining Cao, Chuck Jia, Roger Temam, Joseph Tribbia. Mathematical analysis of a cloud resolving model including the ice microphysics. Discrete & Continuous Dynamical Systems - A, 2021, 41 (1) : 131-167. doi: 10.3934/dcds.2020219 [7] Li-Bin Liu, Ying Liang, Jian Zhang, Xiaobing Bao. A robust adaptive grid method for singularly perturbed Burger-Huxley equations. Electronic Research Archive, 2020, 28 (4) : 1439-1457. doi: 10.3934/era.2020076 [8] Zexuan Liu, Zhiyuan Sun, Jerry Zhijian Yang. A numerical study of superconvergence of the discontinuous Galerkin method by patch reconstruction. Electronic Research Archive, 2020, 28 (4) : 1487-1501. doi: 10.3934/era.2020078 [9] Yuxia Guo, Shaolong Peng. A direct method of moving planes for fully nonlinear nonlocal operators and applications. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020462 [10] Noah Stevenson, Ian Tice. A truncated real interpolation method and characterizations of screened Sobolev spaces. Communications on Pure & Applied Analysis, 2020, 19 (12) : 5509-5566. doi: 10.3934/cpaa.2020250 [11] Jianquan Li, Xin Xie, Dian Zhang, Jia Li, Xiaolin Lin. Qualitative analysis of a simple tumor-immune system with time delay of tumor action. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020341 [12] A. M. Elaiw, N. H. AlShamrani, A. Abdel-Aty, H. Dutta. Stability analysis of a general HIV dynamics model with multi-stages of infected cells and two routes of infection. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020441 [13] Leilei Wei, Yinnian He. A fully discrete local discontinuous Galerkin method with the generalized numerical flux to solve the tempered fractional reaction-diffusion equation. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020319 [14] Marion Darbas, Jérémy Heleine, Stephanie Lohrengel. Numerical resolution by the quasi-reversibility method of a data completion problem for Maxwell's equations. Inverse Problems & Imaging, 2020, 14 (6) : 1107-1133. doi: 10.3934/ipi.2020056 [15] Gang Bao, Mingming Zhang, Bin Hu, Peijun Li. An adaptive finite element DtN method for the three-dimensional acoustic scattering problem. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020351 [16] Zuliang Lu, Fei Huang, Xiankui Wu, Lin Li, Shang Liu. Convergence and quasi-optimality of $L^2-$norms based an adaptive finite element method for nonlinear optimal control problems. Electronic Research Archive, 2020, 28 (4) : 1459-1486. doi: 10.3934/era.2020077

2018 Impact Factor: 1.313