Successive spike times predicted by a stochastic neuronal model with a variable input signal

Giuseppe  D'Onofrio; Enrica Pirozzi

doi:10.3934/mbe.2016003

Article Contents

2016, Volume 13, Issue 3: 495-507. Doi: 10.3934/mbe.2016003

This issue Previous Article A leaky integrate-and-fire model with adaptation for the generation of a spike train Next Article Efficient information transfer by Poisson neurons

Successive spike times predicted by a stochastic neuronal model with a variable input signal

Giuseppe D'Onofrio^1, and
Enrica Pirozzi^2,

1.
Dipartimento di Matematica e Applicazioni, Università degli studi di Napoli, FEDERICO II, Via Cinthia, Monte S.Angelo, Napoli, 80126
2.
Dipartimento di Matematica e Applicazioni “R. Caccioppoli”, Università di Napoli Federico II, Via Cintia, 80126 Napoli

Received: March 31, 2015

Revised: October 31, 2015

Published: December 2015

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Abstract

Two different stochastic processes are used to model the evolution of the membrane voltage of a neuron exposed to a time-varying input signal. The first process is an inhomogeneous Ornstein-Uhlenbeck process and its first passage time through a constant threshold is used to model the first spike time after the signal onset. The second process is a Gauss-Markov process identified by a particular mean function dependent on the first passage time of the first process. It is shown that the second process is also of a diffusion type. The probability density function of the maximum between the first passage time of the first and the second process is considered to approximate the distribution of the second spike time. Results obtained by simulations are compared with those following the numerical and asymptotic approximations. A general equation to model successive spike times is given. Finally, examples with specific input signals are provided.

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Mathematics Subject Classification: Primary: 60G20, 60J70; Secondary: 65C30.

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